Calcium Signaling

by Bootman, Michael; Berridge, Michael J; Putney, James W.; Roderick, H. Llewelyn

• ISBN13: 9780879699031
• ISBN10: 0879699035
• Format: Hardcover
• Copyright: 2011-09-20
• Publisher: Cold Spring Harbor Laboratory Press

Summary

Much is known about regulation of calcium fluxes, channels and pumps that transport calcium between different compartments, cytosolic calcium buffers and sensors and how these products distinct spatiotemporal calcium signals in different circumstances. This book covers these aspects of the field, together with newer work implicating calcium in the regulation of apoptosis during normal physiology and necrotic cell death in pathological conditions such as stroke and ischemia.

Table of Contents

Preface	p. vii
Calcium Signal Generation/Modulation And Homeostasis
Calcium Entry
Voltage-Gated Calcium Channels	p. 1
The Role of Transient Receptor Potential Cation Channels in Ca2+ Signaling	p. 25
Store-Operated Calcium Channels: New Perspectives on Mechanism and Function	p. 57
mGluR1/TRPC3-Mediated Synaptic Transmission and Calcium Signaling in Mammalian Central Neurons	p. 81
Calcium Release
Ryanodine Receptors: Structure, Expression, Molecular Details, and Function in Calcium Release	p. 97
IP3 Receptors: Toward Understanding Their Activation	p. 119
NAADP Receptors	p. 141
Calcium Oscillations	p. 159
Calcium Buffers and Pumps Cytosolic Ca2+ Buffers	p. 177
Organellar Calcium Buffers	p. 197
The Plasma Membrane Ca2+ ATRase and the Plasma Membrane Sodium Calcium Exchanger Cooperate in the Regulation of Cell Calcium	p. 213
The Ca2+ Pumps of the Endoplasmic Reticulum and Golgi Apparatus	p. 229
Functional Aspects Of Calcium Signaling
Proteins Mediating Effects of Calcium
The Diversity of Calcium Sensor Proteins in the Regulation of Neuronal Function	p. 253
Regulation by Ca2+ -Signaling Pathways of Adenylyl Cyclases	p. 273
Protein Kinase C: The "Masters" of Calcium and Lipid	p. 295
Physiological Processes Regulated by Calcium
Ca3+ Signaling During Mammalian Fertilization: Requirements, Players, and Adaptations	p. 313
Calcium Signaling in Neuronal Development	p. 337
Visualization of Ca2+ Signaling During Embryonic Skeletal Muscle Formation in Vertebrates	p. 351
Calcium Signaling in Synapse-to-Nucleus Communication	p. 371
Calcium Signaling in Cardiac Myocytes	p. 403
Calcium Signaling in Smooth Muscle	p. 423
Calcium in Cell Death and Disease Apoptosis and Autophagy: Decoding Calcium Signals that Mediate Life or Death	p. 443
Endoplasmic-Reticulum Calcium Depletion and Disease	p. 461
Index	p. 491
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