Cancer Chemotherapy and Biotherapy Principles and Practice

by Chabner, Bruce A.; Longo, Dan L.

• ISBN13: 9780781722698
• ISBN10: 0781722691
• Edition: 3rd
• Format: Hardcover
• Copyright: 2001-08-27
• Publisher: LWW

Summary

Updated to include the newest drugs and those currently in development, this Fourth Edition is a comprehensive reference on the preclinical and clinical pharmacology of anticancer agents. Organized by drug class, the book provides the latest information on all drugs and biological agents their mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance. The authors explain the rationale for use of drugs in specific schedules and combinations and offer guidelines for dose adjustment in particular situations. This edition provides expanded coverage of monoclonal antibodies, molecularly targeted drugs, vaccines, cell based therapies, growth factors, and pharmacogenetics.

Table of Contents

Contributing Authors	p. vii
Preface	p. xi
Acknowledgments	p. xii
Clinical Strategies for Cancer Treatment: The Role of Drugs	p. 1
Preclinical Aspects of Cancer Drug Discovery and Development	p. 17
Pharmacokinetics and Clinical Monitoring	p. 37
Infertility after Cancer Chemotherapy	p. 50
Carcinogenesis: A Late Complication of Cancer Chemotherapy	p. 67
Steroid Hormone Therapies for Cancer	p. 85
Antifolates	p. 139
5-Fluoropyrimidines	p. 185
Cytidine Analogs	p. 265
Purine Antimetabolites	p. 295
Hydroxyurea	p. 315
Antimicrotubule Agents	p. 329
Alkylating Agents	p. 373
Nonclassic Alkylating Agents	p. 415
Cisplatin and Analogs	p. 447
Bleomycin	p. 466
Antitumor Antibiotics	p. 482
Anthracyclines and Anthracenediones	p. 500
Topoisomerase II Inhibitors: Epipodophyllotoxins, Acridines, Ellipticines, and Bisdioxopiperazines	p. 538
Topoisomerase I Targeting Agents: The Camptothecins	p. 579
Enzyme Therapy: L-Asparaginase	p. 647
Pharmacologic Considerations in Chemotherapy for Brain Tumors	p. 657
Retinoids and Other Differentiating Agents	p. 678
Bisphosphonates	p. 700
Radiation Modifiers	p. 707
Pharmacology of Interferons: Induced Proteins, Cell Activation, and Antitumor Activity	p. 752
Clinical Pharmacokinetics of Interleukin 1, Interleukin 2, Interleukin 4, Tumor Necrosis Factor, Interleukin 12, and Macrophage Colony-Stimulating Factor	p. 779
Colony-Stimulating Factors	p. 829
Antibody-Based Immunotherapies for Cancer	p. 850
Targeted Therapy	p. 891
Physical Barriers to Drug Delivery	p. 911
Adoptive Cellular Therapy	p. 925
Cancer Vaccines 2001	p. 951
Cytokine and Growth Factor and Receptor Database: Biologic, Molecular, and Pathophysiologic Properties of Ligand-Receptor Interactions	p. 960
Inhibitors of Tumor Angiogenesis	p. 988
Pharmacogenetics	p. 998
Chemokine--Chemokine Receptor Database 2001: Biologic, Molecular, and Pathophysiologic Properties of Chemokine-Receptor Interactions	p. 1012
Index	p. 1129
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