Cancer Epigenetics Biomolecular Therapeutics in Human Cancer

by Giordano, Antonio; Macaluso, Marcella

• ISBN13: 9780471710967
• ISBN10: 0471710962
• Edition: 1st
• Format: Hardcover
• Copyright: 2011-08-23
• Publisher: Wiley-Blackwell

Summary

This book focuses on the most promising developments in novel therapeutics for cancer patients. Its presentation of the latest research in cancer biology reflects the interdisciplinary nature of the field and aims to facilitate collaboration between the basic, translational, and clinical sciences.

Author Biography

Antonio Giordano, M.D., Ph. D., is professor of biology and medical research at Temple University College of Science and Technology in Philadelphia, Pennsylvania. In 1993 he co-founded the Sbarro Institute for Cancer Research and Molecular Medicine. He has been honored as Knight by the president of Italy and is recipient of the National Italian-American Political Action Committee (NIA-PAC) National Lifetime Achievement Award in Medical Research.

Marcella Macaluso, Ph.D., is associate professor of biology and a researcher in the Hormone-Signaling and Cancer Program of the Sbarro Institute for Cancer Research at Temple University in Philadelphia.

Table of Contents

Contributors	p. qxi
Preface	p. xv
Epigenetics and Cell Cycle	p. 1
Epigenetic Modulation of Cell Cycle: An Overview	p. 3
Epigenetics and Cell Development, Senescence and Differentiation	p. 15
Epigenetics in Skeletal Muscle Development	p. 17
Epigenetic Control in Cellular Senescence	p. 25
Epigenetic Modulation in Cell Development and Differentiation	p. 45
Epigenetics and Gene Transcription	p. 57
Epigenetic Control of Gene Transcription	p. 59
Epigenetics, MicroRNAs, and Cancer: An Update	p. 101
Epigenetics and Cancer	p. 113
The Role of Epigenetic Modifications in Cancer	p. 115
MBD4/MED1 Protein in DNA Repair and Demethylation, Cancer, and Other Diseases	p. 145
Epigenetics in Pediatric Cancers	p. 163
Epigenetic Mechanisms in Cancer Formation and Progression	p. 253
Epigenetics and Anticancer Drug Development and Therapy	p. 299
Recent Advances in the Field of Stem Cell Research: Toward the Definition of the Epigenetic and Genetic Codes of Pluripotency	p. 301
Potential of Heat Shock Protein Targeting for Human Therapy	p. 315
Advances in Stem Cell Therapy for Cancer Research	p. 337
Epigenetic Targets and Drug Development	p. 351
Index	p. 369
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