Cancer Genome and Tumor Microenvironment

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  • Format: Hardcover
  • Copyright: 2009-12-07
  • Publisher: Springer Verlag

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Oncogenes and tumor suppressor genes had been traditionally studied in the context of cell proliferation, differentiation, senescence, and survival, four relatively cell-autonomous processes. Consequently, in the late ’80s-early ’90s, neoplastic growth was described largely as an imbalance between net cell accumulation and loss, brought about through mutations in cancer genes. In the last ten years, a more holistic understanding of cancer has slowly emerged, stressing the importance of interactions between neoplastic and various stromal components: extracellular matrix, basement membranes, fibroblasts, endothelial cells of blood and lymphatic vessels, tumor-infiltrating lymphocytes, etc. The commonly held view is that changes in tumor microenvironment are soft-wired”, i.e., epigenetic in nature and often reversible. Yet, there exists a large body of evidence suggesting that well-known mutations in cancer genes profoundly affect tumor milieu. In fact, these non-cell-autonomous changes might be one of the primary reasons such mutations are preserved in late-stage tumors.

Table of Contents

Opening Remarks
Hardwiring Tumor Progressionp. 3
Breaking Away: Epithelial-Mesenchymal Transition
PI3K/AKT Pathway and the Epithelial-Mesenehymal Transitionp. 11
Loss of Cadherin-Catenin Adhesion System in Invasive Cancer Cellsp. 33
Rho GTPases in Regulation of Cancer Cell Motility, Invasion, and Microenvironmentp. 67
Merlin/NF2 Tumor Suppressor and Ezrin-Radixin-Moesin (ERM) Proteins in Cancer Development and Progressionp. 93
Coming Up for Air: Hypoxia and Angiogenesis
von Hippel-Lindau Tumor Suppressor, Hypoxia-Inducible Factor-1, and Tumor Vascularizationp. 119
RAS Oncogenes and Tumor-Vascular Interfacep. 133
Myc and Control of Tumor Neovascularizationp. 167
p53 and Angiogenesisp. 189
Ink4a Locus: Beyond Cell Cyclep. 217
Gaining New Ground: Metastasis and Stromal Cell Interactions
Nm23 as a Metastasis Inhibitorp. 233
HGF/c-MET Signaling in Advanced Cancersp. 273
Contribution of ADAMs and ADAMTSs to Tumor Expansion and Metastasisp. 293
Stromal Cells and Tumor Milieu: PDGF et alp. 315
TGF-ß Signaling Alterations in Neoplastic and Stromal Cellsp. 335
Getting Attention: Immune Recognition and Inflammation
Genetic Instability and Chronic Inflammation in Gastrointestinal Cancersp. 351
Immunoglobulin Gene Rearrangements, Oncogenic Translocations, B-Cell Receptor Signaling, and B Lymphomagenesisp. 399
Modulation of Philadelphia Chromosome-Positive Hematological Malignancies by the Bone Marrow Microenvironmentp. 427
Putting It All Together
Melanoma: Mutations in Multiple Pathways at the Tumor-Stroma Interfacep. 455
Cooperation and Cancerp. 471
Indexp. 487
Table of Contents provided by Ingram. All Rights Reserved.

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