Cancer Informatics

by Silva, John S.; Chute, Christopher; Ball, Marion; Douglas, Judith; Langlotz, Curtis P.

• ISBN13: 9780387953281
• ISBN10: 0387953280
• Format: Hardcover
• Copyright: 2002-01-01
• Publisher: Springer Verlag

Summary

Cancer Informatics: Essential Technologies for Clinical Trials describes the National Cancer Institute¿s vision of a Cancer Informatics Infrastructure (CII). By exploiting the best that the Internet and information technology have to offer, the CII will facilitate clinical trials, for all who are involved, including the patient along with the myriad of health professionals involved in cancer trials.To bridge the chasm between discoveries and best clinical practices, the editors describe the CII and how it can function to expedite the clinical trial life cycle, facilitate faster and safer drug development, and make more appropriate treatment choices available to cancer patients.Presented in four comprehensive sections edited by leading experts, the book highlights:¿ E-commerce¿ Digital libraries¿ Standards development¿ Public health informatics¿ Common data elements (CDEs)¿ Clinical trials information systems¿ Consumer education and supportCancer Informatics: Essential Technologies for Clinical Trials is an indispensable guide to clinical trials. Its contributors speak to oncologists and primary care physicians, as well as researchers, trial managers, administrators, informaticians, and consumers.Today, science is extending our knowledge of genes, proteins, and pathways, and pharmaceutical companies are developing more and more new therapies. In this rapidly changing world, the technologies that cancer informatics provides are essential to efforts to translate cancer research into cancer care, control, and, ultimately, prevention.John S. Silva, M.D., Center for Bioinformatics, National Cancer InstituteMarion J. Ball, Ed.D., Vice President, Clinical Solutions, Healthlink, Inc.; Adjunct Professor, The Johns Hopkins University School of NursingChristopher G. Chute, M.D., Dr.P.H., Professor of Medical Informatics, Head, Section of Medical Information Resources, Mayo ClinicJudith V. Douglas, M.A., M.H.S., formerly Associate, First Consulting Group Curtis P. Langlotz, M.D., Ph.D., Assistant Professor of Radiology, Epidemiology, and Computer and Information Science, University of PennsylvanniaJoyce. C. Niland, Ph.D., Chair, Division of Information Sciences, Director, Department of Biostatistics, City of Hope National Medical CenterWilliam L. Scherlis, Ph.D., Principal Research Scientist, School of Computer Science, Carnegie Mellon University

Table of Contents

Dedication	v
Tenley E. Albright
Foreword	vii
Richard D. Klausner
Series Preface	xi
Editors' Preface	xiii
Acknowledgments	xvii
Contributors	xxiii
SECTION 1 THE VISION
John S. Silva
Marion J. Ball
Judith V. Douglas
Introduction Envisioning a National Cancer Information and Knowledge Environment	3	(2)
John S. Silva
Translating Cancer Research into Cancer Care: Final Report of the Long Range Planning Committee	5	(12)
Long Range Planning Committee
Visions of the Future	17	(16)
Long Range Planning Committee
Clinical Trials in Practice	33	(18)
L. Michael Glode
SECTION 2 THE INFRASTRUCTURE
William L. Scherlis
Introduction Developing and Improving the Informatics Infrastructure to Support Clinical Research	47	(4)
William L. Scherlis
Cancer Informatics: Lessons from the World of e-Business	51	(19)
Jay M. Tenenbaum
Security and Privacy	70	(9)
Clifford Neuman
Digital Libraries and Scholarly Communication	79	(23)
Ronald L. Larsen
Jean Scholtz
SECTION 3 STANDARDS AND VOCABULARY
Christopher G. Chute
Curtis P. Langlotz
Introduction The Spectrum of Existing and Emerging Health Data Standards: Their Relevance and Application to Cancer Information	99	(3)
Christopher G. Chute
Curtis P. Langlotz
Cancer Data, Information Standards, and Convergent Efforts	102	(4)
Christopher G. Chute
Toward Terminology as Infrastructure	106	(16)
Mark S. Tuttle
Keith E. Campbell
Kevin D. Keck
John S. Carter
Clinical Terminologies for Data Analysis and Structured Data Entry	122	(13)
Walter Sujansky
Information Standards Within the National Cancer Institute	135	(22)
Francis W. Hartel
Sherri de Coronado
CDE Development Model for Chest CT Screening for Lung Cancer	157	(9)
Curtis P. Langlotz
Pathology Standards in Cancer Informatics	166	(10)
Kent A. Spackman
M. Elizabeth Hammond
Clinical Information Interchange with Health Level Seven	176	(18)
Stanley M. Huff
W. Ed Hammond
Warren G. Williams
The Health Level Seven Reference Information Model	194	(12)
Abdul-Malik Shakir
HIPAA Administrative Simplification Standards: Provisions of the Final Privacy Rule Related to Clinical Trials	206	(6)
William R. Braithwaite
Toward a Shared Representation of Clinical Trial Protocols: Application of the GLIF Guideline Modeling Framework	212	(17)
Robert A. Greenes
Samson Tu
Aziz A. Boxwala
Mor Peleg
Edward H. Shortliffe
Informatics for Cancer Prevention and Control	229	(21)
Robert A. Hiatt
SECTION 4 THEORY INTO PRACTICE
Joyce C. Niland
Introduction Moving Toward the Vision: Putting Applications in Place	245	(5)
Joyce C. Niland
Selection of Oncology Information Systems	250	(20)
Mitchell Morris
Clinical State Diagrams and Informatics Tools for Clinical Trial Protocols	270	(10)
John H. Gennari
Support for the Cancer Patient: An Internet Model	280	(13)
Howard S. Goldberg
Charles Safran
Increasing Clinical Trial Awareness and Accrual Via the Web	293	(9)
Joyce C. Niland
Douglas C. Stahl
ClinicalTrials.gov: Linking Patients to Medical Research	302	(6)
Alexa T. McCray
The National Cancer Institute's net-Trials™	308	(9)
Dianne M. Reeves
Douglas Hageman
iN: A Community-Based Cancer Informatics and Clinical Trials Network	317	(12)
Donald W. Simborg
Consumer Health Informatics	329	(26)
Deborah K. Mayer
Susan M. Hubbard
An Internet-Based Data System for Outcomes Research	355	(14)
Joyce C. Niland
Index	369