Cancer Medicine

by Holland, James F.; Bast, Robert C., Jr.; Morton, Donald L.; Frei, Emil, III, M.D.

• ISBN13: 9780683040951
• ISBN10: 0683040952
• Edition: 4th
• Format: Hardcover
• Copyright: 1996-09-01
• Publisher: Williams & Wilkins

Table of Contents

Preface	v	(2)
Contributors	vii
VOLUME ONE
SECTION I CANCER BIOLOGY	3	(204)
1 Cell Proliferation and Differentiation	3	(16)
Howard J. Fingert, M.D.
Judith Campisi, Ph.D.
Arthur B. Pardee, Ph.D.
2 Molecular Biology	19	(22)
Barrett J. Rollins, M.D., Ph.D.
Charles D. Stiles, Ph.D.
3 Growth Factors	41	(24)
Paolo Fedi, M.D., Ph.D.
Steven R. Tronick, Ph.D.
Stuart A. Aaronson, M.D.
4 Signal Transduction in Cancer	65	(20)
Yusuf A. Hannun, M.D.
5 Oncogenes	85	(12)
Steven A. Schichman, M.D., Ph.D.
Carlo H. Croce, M.D.
6 Tumor Suppressor and DNA Repair Gene Defects in Human Cancer	97	(22)
Eric R. Fearon, M.D., Ph.D.
Bert Vogelstein, M.D.
7. Recurring Chromosome Rearrangements in Human Cancer	119	(24)
Olufunmilayo I. Olopade, M.D.
Janet D. Rowley, M.D., D.Sc.
8. Biochemistry of Cancer	143	(22)
Edward Bresnick, Ph.D.
9. Invasion and Metastasis	165	(16)
Lance A. Liotta, M.D., Ph.D.
Elise C. Kohn, M.D.
10. Tumor Angiogenesis	181	(26)
Judah Folkman, M.D.
SECTION II TUMOR IMMUNOLOGY	207	(38)
11. Tumor Immunology	207	(38)
Robert C. Bast, Jr., M.D.
Gordon B. Mills, M.D., Ph.D.
Spencer Gibson, Ph.D.
Cinda M. Boyer, Ph.D.
SECTION III CANCER ETIOLOGY	245	(156)
12. Genetic Predisposition to Cancer	245	(16)
Bruce A. J. Ponder, Ph.D., F.R.C.P.
13. Chemical Carcinogenesis	261	(16)
Ainsley Weston, Ph.D.
Curtis C. Harris, M.D.
14. Hormones and the Etiology of Cancer	277	(16)
Brian E. Henderson, M.D.
Leslie Bernstein, Ph.D.
Ronald K. Ross, M.D.
15. Ionizing Radiation	293	(14)
John B. Little, M.D.
16. Ultraviolet Radiation Carcinogenesis	307	(12)
James E. Cleaver, Ph.D.
David L. Mitchell, Ph.D.
17. Carcinogenesis from Low-Frequency Electromagnetic Fields	319	(6)
Cesare Maltoni, M.D.
Morando Soffritti, M.D.
18. Physical Carcinogens	325	(8)
Cesare Maltoni, M.D.
Franco Minardi, M.D.
19. Trauma and Inflammation	333	(4)
John F. Gaeta, M.D.
20. RNA Tumor Viruses	337	(18)
Howard A. Fine, M.D.
Joseph G. Sodroski, M.D.
21. Herpesviruses	355	(10)
Jeffrey I. Cohen, M.D.
22. Papillomaviruses and Cervical Neoplasia	365	(10)
Catherine M. McLachlin, M.D., F.R.C.P.C.
Christopher P. Crum, M.D.
23. Hepatitis Viruses	375	(14)
Max W. Sung, M.D.
Swan N. Thung, M.D.
George Acs, M.D., Ph.D.
24. Parasites	389	(12)
Piero Mustacchi, M.D.
SECTION IV CANCER EPIDEMIOLOGY	401	(22)
25. Cancer Epidemiology	401	(22)
Frederick P. Li, M.D.
Arlene F. Kantor, Dr. P.H.
SECTION V THEORY AND PRACTICE OF CLINICAL TRIALS	423	(24)
26. Theory and Practice of Clinical Trials	423	(24)
Marvin Zelen, Ph.D.
SECTION VI CANCER PREVENTION	447	(64)
27. Prevention of Tobacco-Related Cancers	447	(18)
Paul F. Engstrom, M.D.
Elizabeth A. Rosvold, M.D.
Neal R. Boyd, Jr., Ed.D, M.S.P.H., C.
Tracy Orleans, Ph.D.
28. Nutrition in the Etiology and Prevention of Cancer	465	(30)
Steven K. Clinton, M.D., Ph.D.
Edward Giovannucci, M.D., D.P.H.
29. Chemoprevention of Cancer	495	(16)
Michael B. Sporn, M.D.
Scott M. Lippman, M.D., F.A.C.P.
SECTION VII CANCER SCREENING AND EARLY DETECTION	511	(22)
30. Cancer Screening and Early Detection	511	(22)
Charles R. Smart, M.D.
Curtis P. Mettlin, Ph.D.
Laszlo Tabar, M.D.
Harmon J. Eyre, MD
SECTION VIII PRINCIPLES OF CANCER PATHOLOGY	533	(26)
31. Principles of Cancer Pathology	533	(26)
James L. Connolly, M.D.
Stuart J. Schnitt, M.D.
Helen H. Wang, M.D. Dr. P.H.
Ann M. Dvorak, M.D.
Harold F. Dvorak, M.D.
SECTION IX PRINCIPLES OF IMAGING	559	(56)
32. Introduction	559	(4)
Richard J. Steckel, M.D.
33. Imaging Cancer of Unknown Primary Site	563	(4)
A. Robert Kagan, M.D.
Richard J. Steckel, M.D.
34. Imaging Neoplasms of the Head, Neck and Central Nervous System	567	(6)
Robert Lufkin, M.D.
35. Imaging Neoplasms of the Thorax	573	(6)
Poonam V. Batra, M.D., F.C.C.P., F.A.C.R.
36. Imaging Neoplasms of the Abdomen and Pelvis	579	(6)
Robert A. Halvorsen, Jr., M.D.
William M. Thompson, M.D.
37. Cross-Sectional Imaging of Musculoskeletal Neoplasms	585	(4)
Leanne L. Seeger, M.D.
38. Imaging the Breast	589	(8)
Lawrence W. Bassett, M.D.
39. Ultrasound in Cancer Medicine	597	(6)
Edward G. Grant, M.D.
40. Radionuclide Imaging in Cancer Medicine	603	(8)
Randall A. Hawkins, M.D., Ph.D.
41. Perspectives in Imaging	611	(4)
Richard J. Steckel, M.D.
SECTION X INTERVENTIONAL RADIOLOGY	615	(16)
42. Interventional Radiology	615	(16)
Sidney Wallace, M.D.
Chusilp Charnsangavej, M.D.
C. Humberto Carrasco, M.D.
SECTION XI ENDOSCOPY	631	(20)
43. Gastrointestinal Endoscopy	631	(14)
J. Mark Lawson, M.D., F.A.C.P., F.A.C.G.
John Baillie, M.B., Ch.B., F.R.C.P.
44. Bronchoscopy	645	(6)
Victor F. Tapson, M.D.
William J. Fulkerson, Jr., M.D.
SECTION XII PRINCIPLES OF SURGICAL ONCOLOGY	651	(46)
45. Principles of Surgical Oncology	651	(14)
Donald L. Morton, M.D.
Ralph C. Jones, Lt. Cdr., M.C., U.S.N.
46. Vascular Access in Cancer Patients	665	(10)
Michail Shafir, M.D.
47. Minimally Invasive Surgery	675	(22)
Michael Edye, M.B., B.S.
Barry Salky, M.D., F.A.C.S.
Steven M. Keller, M.D.
T. Scott Jennings, M.D.
Peter R. Dottino, M.D.
Nelson N. Stone, M.D.
SECTION XIII PRINCIPLES OF RADIATION ONCOLOGY	697	(58)
48. Biological and Physical Basis of Radiation Oncology	697	(30)
Ralph R. Weichselbaum, M.D.
George Chen, M.D.
Dennis E. Hallahan, M.D.
49. Principles of Hyperthermia	727	(12)
Daniel S. Kapp, Ph.D., M.D.
George M. Hahn, Ph.D.
Robert W. Carlson, M.D.
50. Photodynamic Therapy of Cancer	739	(16)
Tayyaba Hasan, Ph.D.
John A. Parrish, M.D.
SECTION XIV PRINCIPLES OF MEDICAL ONCOLOGY	755	(14)
51. Principles of Medical Oncology	755	(14)
James F. Holland, M.D.
Emil Frei III, M.D.
Donald W. Kufe, M.D.
Robert C. Bast, Jr., M.D.
SECTION XV PRINCIPLES OF CHEMOTHERAPY	769	(138)
52. Cytokinetics	769	(30)
Antonella Surbone, M.D.
Teresa Ann Gilewski, M.D.
Larry Norton, M.D.
53. Drug Resistance and Its Clinical Circumvention	799	(18)
Charles S. Morrow, M.D., Ph.D.
Kenneth H. Cowan, M.D., Ph.D.
54. Combination Chemotherapy, Dose, and Schedule	817	(22)
Emil Frei III, M.D.
Karen H. Antman, M.D.
55. Regional Chemotherapy	839	(16)
Stephen B. Howell, M.D.
56. Animal Models in Drug Development	855	(14)
Samir N. Khleif, M.D.
Gregory A. Curt, M.D.
57. In Vitro and In Vivo Predictive Tests	869	(6)
Axel-R. Hanauske, M.D., Ph.D.
Daniel D. Von Hoff, M.D., F.A.C.P.
58. Pharmacology	875	(16)
Mark J. Ratain, M.D.
William Plunkett, Ph.D.
59. Toxicology by Organ System	891	(16)
Michael R. Grever, M.D.
Charles K. Grieshaber, Ph.D.
SECTION XVI CHEMOTHERAPEUTIC AGENTS	907	(142)
60. Folate Antagonists	907	(16)
Joseph R. Bertino, M.D.
Barton A. Kamen, M.D., Ph.D.
Antonella Romanini, M.D.
61. Pyrimidine and Purine Antimetabolites	923	(26)
Giuseppe Pizzorno, Ph.D., Pharm.D.
Yung-Chi Cheng, Ph.D.
Robert E. Handschumacher, Ph.D.
62. Alkylating Agents and Platinum Antitumor Compounds	949	(28)
O. Michael Colvin, M.D.
63. Anthracyclines and DNA Intercalators	977	(12)
Charles Myers, M.D.
64. Epipodophyllotoxins	989	(8)
Antoinette J. Wozniak, M.D.
Warren E. Ross, M.D.
65. DNA Topoisomerase I Inhibitors	997	(8)
Robert Silber, M.D.
66. Anticancer Drugs From Plants: Vinca Alkaloids and Taxanes	1005	(22)
William T. Beck, Ph.D.
Carol E. Cass, Ph.D.
Peter J. Houghton, Ph.D.
67. Asparaginase	1027	(10)
Joanne Kurtzberg, M.D.
68. Antitumor Activity of Polyanions	1037	(12)
Charles Myers, M.D.
SECTION XVII PRINCIPLES OF ENDOCRINE THERAPY	1049	(120)
69. Steroid Hormone Binding and Hormone Receptors	1049	(12)
Elwood V. Jensen, M.D.
Eugene R. DeSombre, Ph.D.
70. Hormone Physiology and Endocrine Ablation	1061	(6)
B. J. Kennedy, M.D.
71. Hypothalamic and Other Peptide Hormones	1067	(20)
Andrew V. Schally, Ph.D., D.Sci., M.D.h.c.
Ana Maria Comaru-Schally, M.D., M.S.
72. Corticosteroids	1087	(16)
Robert A. Schwartzman, Ph.D.
John A. Cidlowski, M.D., M.S.
73. Estrogens and Antiestrogens	1103	(10)
V. Craig Jordan, Ph.D., D.Sc.
74. Clinical Use of Aromatase Inhibitors in Breast Carcinoma	1113	(12)
Harold A. Harvey, M.D.
Andrea Manni, M.D.
75. Progestins	1125	(8)
Kenneth S. McCarty, Jr., M.D., Ph.D.
Kenneth S. McCarty, Sr., Ph.D.
76. Androgens and Antiandrogens	1133	(16)
Nicholas Bruchovsky, M.D., Ph.D., F.R.C.P.
77. Paraneoplastic Syndromes	1149	(20)
William D. Odell, M.D., Ph.D., M.A.C.P.
SECTION XVIII PRINCIPLES OF BIOTHERAPEUTICS	1169	(96)
78. Immunostimulants	1169	(10)
Robert C. Bast, Jr., M.D.
Donald L. Morton, M.D.
79. Active Specific Immunotherapy with Vaccines	1179	(20)
Mepur H. Ravindranath, Ph.D.
Donald L. Morton, M.D.
80. Interferons	1199	(14)
Ernest C. Borden, M.D.
81. Cytokines: Biology and Applications in Cancer Medicine	1213	(14)
David R. Parkinson, M.D.
Elizabeth A. Grimm, Ph.D.
82. Hematopoietic Growth Factors	1227	(18)
George D. Demetri, M.D.
83. Monoclonal Serotherapy	1245	(20)
Robert C. Bast, Jr., M.D.
Michael R. Zalutsky, Ph.D.
Arthur Edward Frankel, M.D.
SECTION XIX PRINCIPLES OF GENE THERAPY	1265	(14)
84. Cancer Gene Therapy	1265	(14)
Howard A. Fine, M.D.
Donald W. Kufe, M.D.
SECTION XX PRINCIPLES OF BONE MARROW TRANSPLANTATION	1279	(48)
85. Autologous Bone Marrow Transplantation	1279	(16)
William P. Peters, M.D., Ph.D.
86. Allogeneic Transplantation	1295	(32)
Richard J. O'Reilly, M.D.
Esperanza B. Papadopoulos, M.D.
SECTION XXI PRINCIPLES OF PSYCHO-ONCOLOGY	1327	(20)
87. Principles of Psycho-Oncology	1327	(20)
Jimmie C. Holland, M.D.
SECTION XXII PRINCIPLES OF ONCOLOGY NURSING	1347	(24)
88. Principles of Oncology Nursing	1347	(24)
Connie Henke Yarbro, R.N., B.S.N.
SECTION XXIII PRINCIPLES OF REHABILITATION MEDICINE	1371	(24)
89. Principles of Cancer Rehabilitation Medicine	1371	(24)
Kristjan T. Ragnarsson, M.D.
SECTION XXIV PRINCIPLES OF MULTIDISCIPLINARY MANAGEMENT	1395	(10)
90. Principles of Multidisciplinary Management	1395	(10)
James F. Holland, M.D.
Emil Frei III, M.D.
Donald W. Kufe, M.D.
Robert C. Bast, Jr., M.D.
Donald L. Morton, M.D.
Ralph R. Weichselbaum, M.D.
SECTION XXV PRINCIPLES OF SOCIETAL ONCOLOGY	1405	(66)
91. Ethical Aspects of Caring for Patients with Cancer	1405	(18)
Ezekiel J. Emanuel, M.D., Ph.D.
Frederic C. Kass, M.D., J.D.
92. Legal Aspects of Cancer	1423	(12)
Joseph M. Taraska, J.D.
93. Government and Cancer Medicine	1435	(12)
John E. Ultmann, M.D.
Marguerite Donoghue, R.N., M.N.
Terry L. Lierman
94. Clinical Oncology in a Reforming Health Care Environment	1447	(4)
Martin N. Raber, M.D.
Joseph S. Bailes, M.D., F.A.C.P.
95. Outcomes Assessment	1451	(8)
Jane Weeks, M.D., M.Sc.
96. Questionable Cancer Therapies	1459	(12)
Stephen Barrett, M.D.
Victor D. Herbert, M.D., J.D.
SECTION XXVI NEOPLASMS OF THE CENTRAL NERVOUS SYSTEM	1471	(46)
97. Neoplasms of the Central Nervous System	1471	(46)
Michael D. Prados, M.D., J.D.
Charles B. Wilson, M.D., J.D.
SECTION XXVII NEOPLASMS OF THE EYE	1517	(22)
98. Neoplasms of the Eye	1517	(22)
David H. Abramson, M.D.
Ira J. Dunkel, M.D.
Beryl McCormick, M.D.
SECTION XXVIII NEOPLASMS OF THE ENDOCRINE GLANDS	1539	(106)
99. Pituitary Neoplasms	1539	(12)
Charles B. Wilson, M.D.
Thomas Mindermann, M.D.
100. Neoplasms of the Thyroid	1551	(12)
Blake Cady, M.D.
Arturo R. Rolla, M.D.
101. Neoplasms of the Adrenal Cortex	1563	(8)
Mary R. Flack, M.D.
George P. Chrousos, M.D.
102. Neoplasms of the Neuroendocrine System	1571	(34)
Li-Teh Wu, M.D.
A. Philippe Chahinian, M.D.
Stephen B. Baylin, M.D.
Norman W. Thompson, M.D., Ph.D.
Steven D. Averbuch, M.D.
103. Neoplasms of the Gastroenteropancreatic Endocrine System	1605	(36)
Arthur I. Vinik, M.D., Ph.D., F.C.P., F.A.C.P.
Roger R. Perry, M.D., F.A.C.S.
104. Pass through to the Gonads	1641	(4)
James F. Holland, M.D.
Emil Frei III, M.D.
Robert C. Bast, Jr., M.D.
Donald W. Kufe, M.D.
Donald L. Morton, M.D.
Ralph R. Weichselbaum, M.D.
SECTION XXIX NEOPLASMS OF THE HEAD AND NECK	1645
105. Head and Neck Cancer	1645	(66)
Gary L. Clayman, D.D.S.
Scott M. Lippman, M.D., F.A.C.P.
George E. Laramore, M.D., Ph.D.
Waun Ki Hong, M.D.
106. Odontogenic Tumors	1711
George T. Gallagher, D.M.D., D.M.Sc.
Gerald Shklar, D.D.S., M.S.