Cancer of the Uterus

by Coukos; George

• ISBN13: 9780824754150
• ISBN10: 0824754158
• Format: Hardcover
• Copyright: 2004-12-20
• Publisher: CRC Press

Summary

The only guide to provide comprehensive coverage of the management of endometrial cancer, as well as cancers in, on, and around the uterus. Studies the impact of diagnostic tools, imaging techniques, and sampling procedures in the evaluation and management of various cancers. Discusses late and advanced stage treatments including radiation and surgery.

Table of Contents

Preface	v
Acknowledgments	ix
Molecular Genetics of Uterine Malignancies	1	(34)
Paul J. Goodfellow
Introduction	1	(2)
Genetic and Environmental Factors	3	(14)
Summary	17	(2)
References	19	(16)
Endometrial Cancer in the Hereditary Nonpolyposis Colorectal Cancer Syndrome	35	(18)
Christina A. Bandera
Introduction	35	(1)
Clinical and Pathologic Features of HNPCC-Related Cancers	36	(3)
Genetic Basis of HNPCC	39	(1)
Identifying the HNPCC Syndrome	40	(4)
Counseling Regarding Screening and Prevention	44	(3)
Conclusion	47	(1)
References	48	(5)
Steroid Hormone Receptors in the Normal Endometrium and in Endometrial Cancer	53	(26)
Kimberly K. Leslie
Suzy Davies
Meenakshi Singh
Harriet O. Smith
Introduction: Endometrial Cancer and the Link to Steroid Hormones and Steroid Receptors	53	(1)
Hormone Receptors in the Normal Endometrium	54	(2)
Hormonal Effects and Hormone Receptors in Endometrial Cancer	56	(2)
Ligand Binding Assays and Immunohistochemistry to Determine Steroid Receptor Status	58	(3)
Cross-Talk and Expression in Endometrial Glands and Stroma	61	(1)
Genomic Effects of SRs	62	(1)
Receptor Isoforms	63	(4)
Non-Genomic Effects of Steroid Hormones Through Membrane and Cytosolic Receptors	67	(1)
References	68	(11)
The Effects of Tamoxifen on the Endometrium	79	(14)
Richard R. Barakat
Introduction	79	(1)
Endometrial Carcinoma	80	(2)
Histology of Tamoxifen-Associated Uterine Cancer	82	(4)
The Role of Screening	86	(4)
References	90	(3)
Pathology of Endometrial Hyperplasia and Carcinoma	93	(56)
Brigitte M. Ronnett
Jeffrey D. Seidman
Richard J. Zaino
Lora Hedrick Ellenson
Robert J. Kurman
Classification	93	(3)
Precursors of Endometrial Carcinoma	96	(12)
Endometrioid Carcinoma	108	(16)
Serous Carcinoma	124	(7)
Clear Cell Carcinoma	131	(2)
Mixed Types of Carcinoma	133	(1)
Malignant Mesodermal Mixed Tumor (MMMT)/Carcinosarcoma	134	(2)
Undifferentiated Carcinoma	136	(1)
Molecular Genetics of Endometrial Cancer	136	(6)
References	142	(7)
Pathology of Uterine Sarcomas	149	(46)
Michael R. Hendrickson
Teri A. Longacre
Richard L. Kempson
Classification of Uterine Mesenchymal, Mixed Mesenchymal, and Epithelial Neoplasms	149	(1)
Endometrial Stromal Sarcoma (ESS)	150	(8)
Uterine Neoplasms with Sex Cord-like Elements	158	(4)
Leiomyosarcoma	162	(8)
Undifferentiated ESS	170	(1)
Miscellaneous Pure Sarcomas	171	(1)
Mixed Mullerian Neoplasms	171	(1)
Adenosarcoma	172	(4)
Carcinosarcoma	176	(4)
References	180	(15)
Clinical Evaluation of Abnormal Uterine Bleeding	195	(34)
Jay M. Cooper
Barbara J. Stegmann
Definition	195	(1)
History and Physical Examination	196	(1)
Etiology	197	(9)
Diagnosis	206	(17)
References	223	(6)
Conservative Treatment of Endometrial Hyperplasia and Early Endometrial Cancer	229	(16)
Genesis Bowen
Thomas Randall
Introduction	229	(1)
Clinical Characteristics	230	(2)
Progestin Therapy	232	(5)
Anticipation of Treatment Failure	237	(3)
Treatment Regimens	240	(2)
References	242	(3)
The Surgical Management of Early Endometrial Cancer	245	(30)
Christina S. Chu
Introduction	245	(1)
Staging	246	(2)
Prognostic Factors	248	(12)
Surgical Approaches	260	(3)
Conclusions	263	(1)
References	264	(11)
The Role of Laparoscopy in the Management of Endometrial Cancer	275	(30)
Joan L. Walker
Robert S. Mannel
Demand for Laparoscopic Surgery	275	(5)
Surgical Techniques for Laparoscopic Treatment of Endometrial Cancer	280	(4)
Current Treatment Algorithms Utilizing Laparoscopy in EC	284	(1)
Surgical Candidate Selection	284	(4)
Training	288	(1)
Potential Benefits of Laparoscopic Surgery	289	(2)
Complications of Laparoscopy	291	(6)
References	297	(8)
The Role of Primary Surgery in Advanced Endometrial Cancer	305	(22)
Robert E. Bristow
F.J. Montz
Introduction	305	(1)
Theoretical Basis for Cytoreductive Surgery	306	(1)
Stage III Endometrial Cancer	307	(5)
Stage IV Endometrial Cancer	312	(5)
Uterine Papillary Serous Carcinoma/Cancer (UPSC)	317	(3)
Conclusion	320	(1)
References	320	(7)
Surgical Management of Recurrent Endometrial Cancer	327	(16)
Nicholas Lambrou
Luis Mendez
Manuel Penalver
Introduction	327	(2)
Pelvic Exenteration	329	(8)
Palliation	337	(1)
References	338	(5)
Radiation Treatment for Early Stage Endometrial Cancer and Uterine Sarcoma	343	(24)
Perry W. Grigsby
Introduction	343	(2)
Endometrial Cancer	345	(9)
Uterine Sarcoma	354	(4)
Endometrial Stromal Sarcoma	358	(2)
Technique of External Irradiation	360	(1)
Techniques for HDR Brachytherapy	361	(1)
References	362	(5)
Radiation Treatment of Advanced or Recurrent Endometrial Cancer	367	(40)
Eleanor E. R. Harris
Role of Radiation Therapy for Stage III--IV EC	368	(14)
Radiation Therapy for Pelvic Recurrence	382	(8)
Radiation Therapy for Medically Inoperable Patients	390	(7)
References	397	(10)
Systemic Therapies for Endometrial Carcinoma	407	(28)
Brian M. Slomovitz
Karen H. Lu
Endometrioid Endometrial Carcinoma (EEC)	408	(5)
Hormonal Therapy	413	(4)
Uterine Papillary Serous Carcinoma (UPSC)	417	(3)
Molecular Therapies	420	(1)
Summary	421	(1)
References	421	(14)
Targeted Therapy of Endometrial Cancer	435	(36)
David O. Holtz
Ronald Buckanovic
George Coukos
Introduction	435	(1)
Epidermal Growth Factor Receptors	436	(4)
Transforming Growth Factors	440	(1)
PTEN--PI3 kinase	441	(3)
Angiogenesis	444	(7)
Invasion and Metastasis	451	(3)
Conclusions	454	(1)
References	454	(17)
Management of Uterine Sarcomas	471	(24)
Gregory Sutton
Heidi J. Gray
Epidemiology and Incidence	471	(2)
Prognostic Factors	473	(1)
Surgical Staging of Uterine Sarcomas	474	(3)
Adjuvant Chemotherapy in Early Uterine Sarcomas	477	(2)
Adjuvant Radiotherapy in Uterine Sarcomas	479	(1)
Palliative Chemotherapy in Uterine Sarcomas	480	(5)
Hormonal Therapy in Uterine Sarcomas	485	(1)
Multimodality Adjuvant Therapy	486	(1)
References	487	(8)
Hormone Replacement in the Patient with Uterine Cancer	495	(12)
Kathleen Lin
Carolyn D. Runowicz
Conclusion	503	(1)
References	504	(3)
Index	507