Cancers of the Skin

by Dummer, R.; Nestle, F. O.; Gurg, G.

• ISBN13: 9783540430056
• ISBN10: 3540430059
• Format: Hardcover
• Copyright: 2002-06-01
• Publisher: Springer Nature

Summary

Skin cancer is the most frequent malignancy in humans and its incidence is still increasing. This situation calls for major efforts to manage the disease. Preventive measures must include reduced UV exposure and an enhanced common awareness of skin lesions. Advanced surgical techniques allow safe removal with excellent cosmetic results. In many cases alternative treatment modalities such as radiotherapy, cryosurgery and photodynamic therapy are applicable. The development of optimal sun screens and UV-protective clothes, new tools for early diagnosis of malignant lesions including videomicroscopy, improved evaluation of biopsy material and new treatment schemes will contribute to better patient care. New developments in therapy including pegylated interferons, cytokine-inducing molecules, monoclonal antibodies and vaccination approaches using peptides, dendritic cells, viruses or nDNA give hope for well-tolerated and efficient treatments.

Table of Contents

Prevention
Public Education in Skin Cancer World-Wide	3	(4)
G. Burg
UV Protection and Skin Cancer	7	(8)
R. Dummer
T. Maier
UV Protection by Clothes
Role of Clothes in Sun Protection	15	(11)
T. Gambichler
P. Altmeyer
K. Hoffmann
Sun Protective Clothing: 5 Years of Experience in Australia	26	(9)
C. R. Roy
P. H. Gies
A. McLennan
European Standards for Protective Apparel Against UV Radiation	35	(7)
J. Laperre
F. Foubert
American Standards for UV-Protective Textiles	42	(6)
K. L. Hatch
Activities of CIE DIV-6 (Photobiology and Photochemistry) in UV Protection and Clothing	48	(7)
J. P. Cesarini
Comparison of Methods: Determination of UV Protection of Clothing	55	(7)
T. Gambichler
P. Altmeyer
K. Hoffmann
Improving UV Protection by Clothing - Recent Developments	62	(8)
U. Osterwalder
H. Rohwer
Dress up for Sun Protection/Creation of Public Awareness	70	(5)
P. Cesarini
Melanoma
Pathogenesis
The Precursors of Malignant Melanoma	75	(10)
A. N. Crowson
C. M. Magro
I. Sanchez-Carpintero
M. C. Mihm Jr.
Interferon-a Sensitivity in Melanoma Cells: Detection of Potential Response Marker Genes	85	(7)
U. Certa
M. Seiler
E. Padovan
G. C. Spagnoli
Molecular Cytogenetics as a Diagnostic Tool for Typing Melanocytic Tumors	92	(8)
B.C. Bastian
Loss of Heterozygosity and Microsatellite Instability in Acquired Melanocytic Nevi: Towards a Molecular Definition of the Dysplastic Nevus	100	(13)
A. Rubben
I. Bogdan
E.I. Gruendorf Conen
G. Burg
R. Boni
Epidemiology
The Changing Incidence and Mortality of Melanoma in Australia	113	(12)
R. Marks
Diagnostic
Why Is Epiluminescence Microscopy Important?	125	(8)
K. Wolff
Sentinel Node Biopsy: Not Only a Staging Tool?	133	(18)
R. Essner
A. J. Cochran
Therapy
The Impact of Surgery on the Course of Melanoma	151	(7)
F. J. Lejeune
Perspectives of Pegylated Interferon Use in Dermatological Oncology	158	(7)
H. Pehamberger
Dendritic Cell Vaccination for the Treatment of Skin Cancer	165	(5)
F.O. Nestle
Gene-based Immunotherapy of Skin Cancers	170	(15)
Y. Sun
D. Schadendorf
Cytokine-Fusion-Protein-Treatment	185	(10)
D. Schrama
P. thor Straten
E.-B. Brocker
R. A. Reisfeld
J. C. Becker
Cytotoxic T-cell Induction in Metastatic Melanoma Patients Undergoing Recombinant Vaccinia Virus-based Immuno-gene Therapy	195	(10)
G. C. Spagnoli
P. Zajac
W. R. Marti
D. Oertli
E. Padovan
C. Noppen
T. Kocher
M. Adamina
M. Heberer
Follow-up
A Rational Approach to the Follow-up of Melanoma Patients	205	(14)
C. Garbe
Epithelial Skin Tumors
Therapy
Micrographic Surgery of Basal Cell Carcinomas of the Head	219	(6)
B. Woerle
M. Heckmann
B. Konz
Repair of Cutaneous Defects After Skin Cancer Surgery	225	(9)
M. Hess Schmid
C. Meuli-Simmen
J. Hafner
Radiotherapy of Skin Tumors	234	(6)
R. Panizzon
Photodynamic Therapy and Fluorescence Diagnosis of Skin Cancers	240	(6)
R.M. Szeimies
M. Landthaler
Intralesional Interferon in Basal Cell Carcinoma: How Does It Work?	246	(5)
S. Buchner
M. Wernli
F. Bachmann
T. Harr
P. Erb
Epithelial Malignancies in Organ Transplant Patients: Clinical Presentation and New Methods of Treatment	251	(8)
E. Stockfleth
C. Ulrich
T. Meyer
E. Christophers
New Treatment Modalities for Basal Cell Carcinoma	259	(12)
E. Stockfleth
W. Sterry
Lymphoma
Pathogenesis
From Inflammation to Neoplasia: New Concepts in the Pathogenesis of Cutaneous Lymphomas	271	(12)
G. Burg
W. Kempf
A. Haeffner
U. Dobbeling
F.O. Nestle
R. Boni
M. Kadin
R. Dummer
Clinical Presentations
Cutaneous Lymphomas and Pseudolymphomas: Newly Described Entities	283	(11)
D. Kazakov
G. Burg
R. Dummer
W. Kempf
Clinical Aspects and Pathology of Primary Cutaneous B-Cell Lymphomas	294	(9)
H. Kerl
R. Fink-Puches
L. Cerroni
Diagnosis
Modern Diagnosis of Cutaneous Lymphoma	303	(6)
B. Giannotti
N. Pimpinelli
Therapy
Treatment of Cutaneous T Cell Lymphoma: 2001	309	(12)
E.C. Vonderheid
New Biologic Agents for the Treatment of Cutaneous T-Cell Lymphoma	321	(10)
C. C. Vittorio
J. M. Junkins-Hopkins
M. Shapiro
M. Wysocka
M. H. Zaki
L. E. French
A. H. Rook
Mesenchymal Tumors
Etiology and Pathogenesis of Kaposi's Sarcoma	331	(12)
B. Nickoloff
K.E. Foreman
Connective Tissue Tumors	343	(8)
B. Zelger
Psychosocial Aspects
How to Identify Patients in Need of Psychological Intervention	351	(11)
G. Strittmatter
M. Tilkorn
R. Mawick
Psychotherapeutic Interventions in Melanoma Patients	362	(9)
W. Sollner
R. Gross
S. Maislinger
Subject Index	371