Carbohydrate Drug Design

by Klyosov, Anatole A.; Witczak, Zbigniew J.; Platt, David

• ISBN13: 9780841239463
• ISBN10: 0841239460
• Edition: 1st
• Format: Hardcover
• Copyright: 2006-06-15
• Publisher: American Chemical Society

Summary

It is becoming more obvious in recent years that carbohydrates present a new dimension in drug design for targeting specific diseases. Carbohydrates birthed a whole new vocabulary into chemistry, biochemistry and related disciplines -- a new language in the form of distinct characters andimages providing professional chemists not in the area of carbohydrates to become familiar and knowledgeable on the topic. Carbohydrate Drug Design provides the indispensable understanding of the mutual challenge between carbohydrate-based drugs and the deadly diseases which they target. Carbohydrate Drug Design discusses pre-clinical studies and clinical trials of carbohydrate-based drugs, drug delivery and pain managements, biocompatibility, clearance and metabolic pathways of carbohydrate drugs, and actual medical devices employing carbohydrates. The invasion of cancer cells,protein-glycan interactions and their inhibitors, new carbohydrate-based therapeutics, crystal structure of antibodies with unusually high affinity for carbohydrates, and a number of other features of carbohydrate drugs are also comprehensively covered. Galactomannans and hyaluronans, as well asthio-, imino- and carba-sugars are particularly considered in respect to their structural and functional impacts.

Table of Contents

Preface	ix
Overview
1. Carbohydrates and Drug Design: What Is New in This Book	2	(23)
Anatole A. Klyosov
2. Carbohydrate Therapeutics: New Developments and Strategies	25	(24)
Zbigniew J. Witczak
Cancer
3. Development of a Polysaccharide as a Vehicle to Improve the Efficacy of Chemotherapeutics	49	(18)
David Platt, Anatole A. Klyosov, and Eliezer Zomer
4. DAVANAT® and Colon Cancer: Preclinical and Clinical (Phase I) Studies	67	(38)
Anatole A. Klyosov, Eliezer Zomer, and David Platt
5. Synthesis and Biological Activity of Doxo-Galactose and Doxo-Galactomannan, New Conjugates of Doxorubicin with E.-Galactose and 1,4,β-D-Galactomannan	105	(28)
Anatole A. Klyosov, Anna N. Tevyashova, Eugenia N. Olsufyeva, Maria N. Preobrazhenskaya, Eliezer Zomer, and David Platt
Human Immunodeficiency Virus
6. Carbohydrate-Based Vaccines against HIV/AIDS	133	(28)
Lai-Xi Wang
7. Toward a Carbohydrate-Based HIV-1 Vaccine	161	(28)
Daniel Calarese, Christopher Scanlan, Hing-Ken Lee, Pauline Rudd, Chi-Huey Wong, Raymond Dwek, Dennis Burton, and Ian A. Wilson
Pathogen Management
8. Cationic Polysaccharides in the Treatment of Pathogenic Candida Infections	189	(16)
Avital Mazar Ben-Josef, David Platt, and Eliezer Zomer
New Approaches in Synthesis and Computational Studies
9. Synthetic Methods to Incorporate a-Linked 2-Amino-2-DeoxyD-Glucopyranoside and 2-Amino-2-Deoxy-D-Galactopyranoside Residues into Glycoconjugate Structures	205	(32)
Robert J. Kerns and Peng Wei
10. Systematic Synthesis of Aminosugars and Their Stereoselective Glycosylation	237	(28)
Jinhua Wang and Cheng-Wei Tom Chang
11. Practical Applications of Computational Studies of the Glycosylation Reaction	265	(38)
Dennis M. Whitfield and Tomoo Nukada
Indexes
Author Index	303	(2)
Subject Index	305