We're sorry, but eCampus.com doesn't work properly without JavaScript.
Either your device does not support JavaScript or you do not have JavaScript enabled.
How to enable JavaScript in your browser.
Need help? Call 1-855-252-4222
What is included with this book?
An insightful reference for the latest physiological and therapeutic studies of carbon monoxide
In Carbon Monoxide in Drug Discovery: Basics, Pharmacology, and Therapeutic Potential, a team of distinguished authors delivers foundational knowledge, the latest research, and remaining challenges regarding the physiological roles and therapeutic efficacy of carbon monoxide (CO). The editors have included a broad selection of resources from leading experts in the field that discuss the background and physiological roles of CO, a variety of delivery forms including CO prodrugs using benign carriers, CO sensing, therapeutic applications, and clinical trials.
Organized by topic to allow each chapter to be read individually, the book covers a wide range of topics, from physiological and patho-physiological mechanisms at the molecular level to clinical applications for multiple disease processes.
The editors of Carbon Monoxide in Drug Discovery have created a compelling argument for shifting the accepted understanding of CO from poison to bioactive molecule with enormous clinical benefits. Readers will also benefit from:
Perfect for professors, graduate students, and postdocs in the fields of biology, pharmacology, immunology, medicinal chemistry, toxicology, and drug delivery, Carbon Monoxide in Drug Discovery: Basics, Pharmacology, and Therapeutic Potential is also an invaluable resource for industrial scientists in these areas.
Binghe Wang, PhD, is Regents’ Professor of Chemistry, Georgia Research Alliance Eminent Scholar, and Director for the Center for Diagnostics and Therapeutics at Georgia State University.
Leo E. Otterbein, PhD, is Professor of Surgery at Harvard Medical School.
List of Contributors viii
Preface: Carbon Monoxide: Promises and Challenges in Its Pharmaceutical Development xii
Section I General Background and Physiological Actions 1
1 Endogenous CO Production in Sickness and in Health 3Ladie Kimberly De La Cruz and Binghe Wang
2 Molecular Mechanisms of Actions for CO: An Overview 27Rodrigo W. Alves de Souza, Leo E. Otterbein, and Nils Schallner
3 Pharmacokinetic Characteristics of Carbon Monoxide 44Xiaoxiao Yang, Mingjia Wang, Chalet Tan, Wen Lu, and Binghe Wang
4 Carbon Monoxide and Energy Metabolism 88Daniela Dias-Pedroso, Nuno Soares, and Helena L.A. Vieira
5 Role of CO in Circadian Clock 97Hiroaki Kitagishi and Ikuko Sagami
6 Carbon Monoxide and Mitochondria 108Claude A. Piantadosi
7 Carbon Monoxide, Oxygen, and Pseudohypoxia 118Grace E. Otterbein, Michael S. Tift, and Ghee Rye Lee
8 Nitric Oxide in Human Physiology: Production, Regulation, and Interaction with Carbon Monoxide Signaling 136Maryam K. Mohammed and Brian S. Zuckerbraun
9 When Carbon Monoxide Meets Hydrogen Sulfide 160Rui Wang
10 Biliverdin and Bilirubin as Parallel Products of CO Formation: Not Just Bystanders 175Libor Vitek
Section II Delivery Forms 195
11 Delivery Systems and Noncarrier Formulations 197James Byrne, Christoph Steiger, Jakob Wollborn, and Giovanni Traverso
12 Metal-Based Carbon Monoxide-Releasing Molecules (CO-RMs) as Pharmacologically Active Therapeutics 203Roberta Foresti, Djamal Eddine Benrahla, Shruti Mohan, and Roberto Motterlini
13 Organic CO Donors that Rely on Photolysis for CO Release 223Yi Liao
14 Organic Carbon Monoxide Prodrugs that Release CO Under Physiological Conditions 232Zhengnan Yuan and Binghe Wang
15 Targeted Delivery of Carbon Monoxide 259Lisa M. Berreau
16 Anesthesia-Related Carbon Monoxide Exposure 286Richard J. Levy
17 Natural Products that Generate Carbon Monoxide: Chemistry and Nutritional Implications 302Ladie Kimberly De La Cruz and Binghe Wang
Section III Carbon Monoxide Sensing and Scavenging 319
18 Fluorescent Probes for Intracellular Carbon Monoxide Detection 321Ryan R. Walvoord, Morgan R. Schneider, and Brian W. Michel
Section IV Therapeutic Applications 345
19 CO in Solid Organ Transplantation 347Roberta Foresti, Roberto Motterlini, and Stephan Immenschuh
20 Carbon Monoxide in Lung Injury and Disease 360Stefan W. Ryter
21 Carbon Monoxide in Acute Brain Injury and Brain Protection 377Alexandra Mazur, Madison Fangman, Rani Ashouri, Hannah Pamplin, Shruti Patel, and Sylvain Doré
22 CO as a Protective Mediator of Liver Injury: The Role of PERK in HO-1/CO-Mediated Maintenance of Cellular Homeostasis in the Liver 385Yeonsoo Joe, Jeongmin Park, Mihyang Do, Stefan W. Ryter, Young-Joon Surh, Uh-Hyun Kim, and Hun Taeg Chung
23 CO and Cancer 401James N. Arnold and Joanne E. Anstee
24 CO and Diabetes 423Rebecca P. Chow and Hongjun Wang
25 Carbon Monoxide and Acute Kidney Injury 434Mark de Caestecker
26 CO as an Antiplatelet Agent: An Energy Metabolism Perspective 453Patrycja Kaczara, Kamil Przyborowski, Roberto Motterlini, and Stefan Chlopicki
27 CO in Gastrointestinal Physiology and Protection 466Katarzyna Magierowska and Marcin Magierowski
28 Carbon Monoxide and Sickle Cell Disease 482Edward Gomperts, John Belcher, Howard Levy, and Greg Vercellotti
29 CO and Pain Management 497Olga Pol
30 Clinical Trials of Low-Dose Carbon Monoxide 511Edward Gomperts, Andrew Gomperts, and Howard Levy
Index 528
The New copy of this book will include any supplemental materials advertised. Please check the title of the book to determine if it should include any access cards, study guides, lab manuals, CDs, etc.
The Used, Rental and eBook copies of this book are not guaranteed to include any supplemental materials. Typically, only the book itself is included. This is true even if the title states it includes any access cards, study guides, lab manuals, CDs, etc.