Carbon Nanotubes for Biomedical Applications

by Klingeler, Rudiger; Sim, Robert B.

• ISBN13: 9783642148019
• ISBN10: 3642148018
• Format: Hardcover
• Copyright: 2011-01-29
• Publisher: Springer Verlag

Summary

This book explores the potential of multi-functional carbon nanotubes for biomedical applications. It combines contributions from chemistry, physics, biology, engineering, and medicine. The complete overview of the state-of-the-art addresses different synthesis and biofunctionalisation routes and shows the structural and magnetic properties of nanotubes relevant to biomedical applications. Particular emphasis is put on the interaction of carbon nanotubes with biological environments, i.e. toxicity, biocompatibility, cellular uptake, intracellular distribution, interaction with the immune system and environmental impact. The insertion of NMR-active substances allows diagnostic usage as markers and sensors, e.g. for imaging and contactless local temperature sensing. The potential of nanotubes for therapeutic applications is highlighted by studies on chemotherapeutic drug filling and release, targeting and magnetic hyperthermia studies for anti-cancer treatment at the cellular level.

Table of Contents

Fundamentals: Synthesis of Multifunctional Nanomaterials and their Potential for Medical Application
Physical Properties of Carbon Nanotubes for Therapeutic Applications	p. 3
Carbon Nanotubes in Regenerative Medicine	p. 27
Filling of Carbon Nanotubes with Compounds in Solution or Melted Phase	p. 41
Filling of Carbon Nanotubes: Containers for Magnetic Probes and Drug Delivery	p. 67
Magnetically Functionalised Carbon Nanotubes for Medical Diagnosis and Therapy
Magnetic Nanoparticles for Diagnosis and Medical Therapy	p. 85
Feasibility of Magnetically Functionalised Carbon Nanotubes for Biological Applications: From Fundamental Properties of Individual Nanomagnets to Nanoscaled Heaters and Temperature Sensors	p. 97
Nuclear Magnetic Resonance Spectroscopy and Imaging of Carbon Nanotubes	p. 125
Interaction with Biological Systems
Exploring Carbon Nanotubes and Their Interaction with Cells Using Atomic Force Microscopy	p. 153
Uptake, Intracellular Localization and Biodistribution of Carbon Nanotubes	p. 169
Recognition of Carbon Nanotubes by the Human Innate Immune System	p. 183
Toxicity and Environmental Impact of Carbon Nanotubes	p. 211
Towards Targeted Chemotherapy and Gene Delivery
Carbon Nanotubes Loaded with Anticancer Drugs: A Platform for Multimodal Cancer Treatment	p. 223
Carbon Nanotubes Filled with Carboplatin: Towards Carbon Nanotube-Supported Delivery of Chemotherapeutic Agents
Functionalized Carbon Nanotubes for Gene Biodelivery	p. 259
Index	p. 275
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