Cardiac Drug Development Guide

by Pugsley, Michael K.

• ISBN13: 9781588290977
• ISBN10: 1588290972
• Edition: Illus.
• Format: Hardcover
• Copyright: 2003-08-01
• Publisher: Humana Pr Inc

Summary

A comprehensive survey of the latest therapeutic drug discoveries in cardiac and cardiovascular medicine and of the most recent breakthroughs in molecular cardiology. The authors describe the most advanced procedures in cardiac pharmacology today, including in vivo and in vitro whole animal studies, the electrophysiological methods used to study in pacemaker cells, and the application of biochemical principles and technologies to novel therapeutic agents. Also discussed are the methods used to express the ion channels involved in cardiovascular pharmacology, adenoviral vector delivery for cardiovascular gene therapy, pharmacometrics in cardiovascular drug development, gender differences in heart failure, and angiogenesis therapies for coronary heart disease.

Table of Contents

Preface
Contributors
Cardiac Drug Development: From Animal Models to Clinical Trials	p. 3
The Role of Cardiac Pacemaker Currents in Antiarrhythmic Drug Discovery	p. 27
Oxygen Free Radicals in Heart Disease: Novel Therapies	p. 47
Mitogen-Activated Protein Kinases-Mediated Signaling in Cardiac Pathology: A Perspective of Novel Therapeutic Targets?	p. 67
Development of Anti-Inflammatory Drugs for Cardiovascular Disease	p. 87
Development and Use of Platelet Glycoprotein Antagonists in Heart Disease	p. 107
The Sodium-Hydrogen Exchange System in the Heart: A Target for the Protection of the Ischemic and Reperfused Heart and Inhibition of Heart Failure	p. 123
Nitric Oxide and Cardiac Ischemia	p. 141
Ionic Mechanisms of Atrial Fibrillation	p. 163
Targeting Ischemic Ventricular Arrhythmias	p. 175
Biochemical Mediators of Ventricular Arrhythmias in Ischemic Heart Disease	p. 203
Heterologous Expression Systems and Screening Technologies in Ion Channel Drug Discovery	p. 227
Molecular Diversity of Ion Channels in the Mouse Heart: A Suitable Model for Cardiac Drug Development?	p. 245
Delayed Protection of the Myocardium: A Novel Therapeutic Window for Cardiac Drug Development	p. 271
Cardiac Troponin Testing for Detection of Myocardial Infarction: Clinical Utility and Analytical Issues	p. 297
A Genetic Basis for Cardiac Arrhythmias: Current Status and the Future	p. 317
Myocardial Adenoviral Vector Delivery for Cardiovascular Gene Therapy	p. 351
The Role of Pharmacometrics in Cardiovascular Drug Development	p. 365
Gender Differences in Heart Failure: Concerns for Drug Development	p. 389
Angiogenesis Therapies for Coronary Artery Disease: Trials and Tribulations	p. 407
Index	p. 421
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