Cardiac Markers

by Wu, Alan H. B.

• ISBN13: 9780896034341
• ISBN10: 0896034348
• Format: Hardcover
• Copyright: 1998-07-01
• Publisher: Humana Pr Inc

Summary

Cardiac Markers is a comprehensive, up-to-date summary of clinical information on serum cardiac markers for coronary artery disease. This book reviews in detail the biochemistry, clinical significance, and analytical measurements for each marker, as well as the advantages and limitations of existing and proposed markers. Comprehensive descriptions of therapeutic approaches to manage patients are presented. Also included are up-to-date listings of primary references and commercial methodologies, the latest data on the pathophysiology of unstable angina, and a discussion of the new emergency-room chest pain centers. Anyone who needs to know how to examine, diagnose, treat, and manage patients with acute chest pain and heart attacks will find this book indispensable.

Table of Contents

Preface	v	(4)
Contributors	ix
PART I CLINICAL ASPECTS	3	(100)
1 Introduction to Coronary Artery Disease (CAD) and Biochemical Markers	3	(18)
Alan H. B. Wu
2 Pathophysiology of Acute Coronary Syndromes	21	(24)
Satyendra Giri
David D. Waters
Alan H. B. Wu
3 Pathophysiology and Treatment of Acute Myocardial Ischemia and Infraction	45	(30)
Gary B. Green
Edward S. Bessman
Sol F. Green
4 Markers of Myocardial Injury in the Evaluation of the Emergency Department Patient with Chest Pain	75	(16)
Gary B. Green
Sol F. Green
5 Ultrastructure of the Striated Muscle Cell	91	(12)
Robert G. McCord
Allen W. Clark
PART II CYTOPLASMIC MARKERS	103	(90)
6 Myoglobin and Carbonic Anhydrase III	103	(10)
Hemant C. Vaidya
H. Kalervo Vaananen
7 Creatine Kinase, Isoenzymes, and Variants	113	(14)
Alan H. B. Wu
8 CK-MB Activity Assays	127	(16)
Alan H. B. Wu
9 CK-MB Measurements by Immunoassay	143	(16)
Sol F. Green
10 CK Isoforms	159	(12)
Sol F. Green
11 Lactate Dehydrogenase and Its Isoenzymes	171	(22)
Shan S. Wong
PART III STRUCTURAL MARKERS	193	(66)
12 Biochemistry and Molecular Biology of Troponins I and T	193	(12)
Kenneth J. Dean
13 Cardiac Troponin T as a Marker of Myocardial Injury	205	(24)
Kenneth J. Dean
14 Cardiac Troponin I	229	(16)
Fred S. Apple
15 Myosin Light and Heavy Chains	245	(14)
Mauro Panteghini
PART IV FUTURE ASSAY AND FORMAT	259	(36)
16 Point-of-Care Testing for Cardiac Markers	259	(22)
Robert H. Christenson
17 New Biochemical Markers for Heart Diseases	281	(14)
Alan H. B. Wu
Robert G. McCord
Index	295