Cardiac Remodeling and Failure

by Singal, Pawan K.; Dixon, Ian M. C.; Kirshenbaum, Lorrie A.; Dhalla, Naranjan S.

• ISBN13: 9781402071775
• ISBN10: 1402071779
• Format: Hardcover
• Copyright: 2003-03-01
• Publisher: Springer Verlag

Summary

The importance of the developmental approach for experimental and clinical cardiology is indisputable. Clinical-epidemiological studies have clearly shown that the risk factors of serious cardiovascular diseases, such as atherosclerosis and ischemic heart disease, are already present during the early phases of ontogenetic development. Furthermore, congenital cardiovascular malformations remain the single largest cause of infant mortality from congenital defects in industrial countries. It is therefore not surprising that the interest of theoretical and clinical cardiologists in the developmental approach keeps increasing. Advances in molecular biology accelerated this trend substantially. This book is based on contributions presented at the international symposium The Developing Heart in Prague in May 2000. It is our contention that the biological, electrophysiological, morphological, functional, biochemical and functional approaches employed by distinguished scientists worldwide will provide the reader with a global picture for changes characterizing the developing heart. It should stimulate the curiosity of cardiovascular scientists in gaining insight into the mechanisms of normal and pathological development.

Table of Contents

Dedication: A Tribute to Dr. Norman Alpert	p. xi
Preface	p. xiii
Acknowledgments	p. xv
Heart Failure and Therapies
Pathophysiology of Heart Failure: Role of Oxygen Free Radicals	p. 3
Therapeutics in Congestive Heart Failure: From Hemodynamics to Neurohormones	p. 17
Dilated Cardiomyopathies and Congestive Heart Failure	p. 35
The Failing SHHF Rat Heart	p. 67
Increased Expression of Na[superscript +]-Ca[superscript 2+] Exchanger in the Myocardium. Impact on Contractility and Arrhythmogenesis in Heart Failure	p. 75
Sarcoplasmic Reticulum Proteins as Potential Targets for Gene Therapy of Heart Failure	p. 87
Sarcoplasmic Reticulum Gene Expression of Ca[superscript 2+]-Cycling Proteins as a Target for the Treatment of Heart Failure	p. 103
Effects of the Beta-Adrenoceptor Blocker Carvedilol in Children with Myocardial Failure	p. 123
The Contractile and Neurohormonal Roles of Phospholamban in Heart Failure	p. 135
Annexins: Roles in the Regulation of Ca[superscript 2+] Handling Proteins During Heart Failure	p. 153
Modulators of Myofibrillar Function: Implications in Myocardial Failure	p. 165
Remodeling and Heart Failure
Structural Remodeling of Cardiac Myocytes in Hypertrophy and Progression to Failure	p. 181
Three-Dimensional Imaging of Microvascular Morphology and Remodeling in Acute and Chronic Myocarditis	p. 195
Alterations in Hemodynamic and Neurohumoral Responses to Exercise in Swine with Left Ventricular Remodeling Early After Myocardial Infarction: Role of Blunted NO Bioavailability	p. 205
Sheep Models of Postinfarction Left Ventricular Remodeling	p. 231
Echocardiographic Characterization of the Cardiovascular Phenotype in Mouse Models	p. 245
A Novel Role for Cytokine Signaling in Cardiac Remodeling	p. 259
Effects of Angiotensin II Receptor Blockade and Angiotensin Converting Enzyme Inhibitor on Ventricular Remodeling After Myocardial Infarction: With Special References to Sarcoplasmic Reticulum and its mRNA	p. 265
The Effect of Bradykinin on the Remodeling of Pressure-Overloaded Myocardium	p. 279
Catecholamines and Cardiac Remodeling	p. 293
Matrix Degradative Enzyme Activities on Cardiac Remodeling in Heart Failure	p. 305
On Atrial Remodeling and Drug Treatment of Atrial Fibrillation	p. 319
Biology of Heart Failure
Infarct Scar. Living Tissue	p. 333
The Use of Bone Marrow Mesenchymal Stem Cells to Repair the Infarcted Heart	p. 345
Role of Na[superscript +]/Ca[superscript 2+] Exchange in Contraction and Relaxation in Immature Ventricular Myocytes	p. 355
Is an Intracrine Renin-Angiotensin System Involved in the Control of Cardiovascular Function?	p. 365
Structural Substrates Involved in the Development of Severe Arrhythmias in Hypertensive Rat and Aged Guinea Pig Hearts	p. 377
Influence of Transgenic Expression of Sarcoplasmic Reticulum Ca[superscript 2+] ATPase on Reticular Ca[superscript 2+] Transport in Rat Hearts	p. 401
Communicating Junctions, Connexins and the Cardiomyocyte: From Cell Biology to Cardiology	p. 417
Mechanisms of Palmitate-Induced Cardiomyocyte Apoptosis	p. 435
Mitochondrial Function in Failing Human Myocardium In Vivo: Atrioventricular Differences	p. 459
Modulation of Heart Fibroblast Gene Expression and Proliferation by Insulin-Like Growth Factor-1	p. 471
Role of Mast Cells in Cardiovascular Disease	p. 485
Regulation of Digitalis Glycoside Receptors in Digoxin Treatment	p. 501
Cardiac Toxicity of Cocaine: From Myocardial Depression to Cardiomyopathy	p. 511
Index	p. 537
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