Cardiovascular Biomarkers

by Morrow, David A.., M.D.; Antman, Elliot, M.D.

• ISBN13: 9781588295262
• ISBN10: 1588295265
• Edition: CD
• Format: Hardcover
• Copyright: 2006-06-07
• Publisher: Humana Pr Inc

Summary

Internationally recognized opinion makers and experts in clinical and laboratory medicine synthesize the latest developments in the use of cardiac biomarkers by the practicing physician. The authors focus on integrating biomarkers into the contemporary clinical management of patients with cardiovascular disease, emphasizing clinical studies, evidence-based diagnostic algorithms, and critical pathways for triage and therapy, whenever available. They also illuminate the connections between specific biomarkers and the basic pathophysiology of cardiovascular disease, explain the analytical properties of the assays relevant to clinical practice, and highlight emerging novel biomarkers and new direction for biomarker development. Numerous figures, illustrations, and tables make key evidence and practical guidelines easily accessible. The book makes clear as never before to today's busy cardiologists, emergency room physicians, and internists how the various assays perform, which ones they should order to evaluate their patients, and how they might change their therapeutic approach based on the results of a biomarker assay.

Table of Contents

Foreword	v
Preface	vii
Contributors	xiii
E-Book/PDA on CD-rom	xvii
PART I BIOMARKERS OF NECROSIS
Biomarkers of Myocardial Necrosis: Past, Present, and Future	3	(24)
Robert H. Christenson
Hassan M. E. Azzazy
Analytical Issues for the Clinical Use of Cardiac Troponin	27	(14)
Alan H. B. Wu
Defining Myocardial Infarction	41	(20)
Allan S. Jaffe
Luciano Babuin
Biomarkers in the Emergency Department: Rapid Diagnosis and Triage	61	(18)
Jin H. Han
W. Brian Gibler
Cardiac Troponin for Risk Assessment and Management of Non-ST-Elevation Acute Coronary Syndrome	79	(14)
Bertil Lindahl
Biomarkers of Necrosis for Risk Assessment and Management of ST-Elevation Myocardial Infarction	93	(10)
Evangelos Giannitsis
Hugo A. Katus
Cardiac Troponin After Revascularization Procedures	103	(16)
Warren J. Cantor
L. Kristin Newby
Biomarkers of Necrosis in Heart Failure: Past, Present, and Future Directions	119	(10)
Emil Missov
James Rider
Leslie Miller
Is There a Role for Cardiac Troponin and Other Biomarkers in Patients With Pulmonary Embolism?	129	(10)
Samuel Z. Goldhaber
Cardiac Troponin in Conditions Other Than Acute Coronary Syndromes	139	(22)
Fred S. Apple
David A. Morrow
Degradation of Cardiac Troponins: Implications for Clinical Practice	161	(16)
Allan S. Jaffe
Jennifer E. Van Eyk
PART II BIOMARKERS OF ISCHEMIA
Developing a Marker of Ischemia: Clinical and Research Challenges	177	(16)
Robert L. Jesse
Emerging Biomarkers of Myocardial Ischemia	193	(14)
Jesse E. Adams
PART III BIOMARKERS OF INFLAMMATION
Inflammation in Cardiovascular Disease: The Biological Basis of Inflammatory Biomarkers	207	(16)
Peter Libby
Analytic Issues for the Clinical Use of C-Reactive Protein	223	(14)
Nader Rifai
C-Reactive Protein as a Tool for Risk Assessment in Primary Prevention	237	(24)
Shari S. Bassuk
Paul M Ridker
High-Sensitivity C-Reactive Protein for Risk Assessment in Acute Coronary Syndromes	261	(16)
Luigi M. Biasucci
Antonio Abbate
Beyond C-Reactive Protein: Novel Markers of Vascular Inflammation	277	(18)
Christopher Heeschen
Biomarkers of Inflammation: Implications in Patients With Heart Failure	295	(24)
Biykem Bozkurt
Biomarkers of Infection and Risk of Coronary Heart Disease	319	(28)
Joseph B. Muhlestein
PART IV BIOMARKERS OF HEMODYNAMIC STRESS
Biology of the Natriuretic Peptides	347	(26)
Charlotte Kragelund
Torbjorn Omland
Analytic Issues for the Clinical Use of B-Type Natriuretic Peptide and N-Terminal Pro B-Type Natriuretic Peptide	373	(14)
Johannes Mair
Clinical Use of Natriuretic Peptides for the Diagnosis and Management of Heart Failure	387	(22)
Alan Maisel
Natriuretic Peptides in Acute and Chronic Coronary Artery Disease	409	(18)
Shuaib M. Abdullah
James A. de Lemos
Novel Markers of Hemodynamic Stress	427	(24)
Ellen O. Weinberg
Richard T. Lee
PART V BIOMARKERS OF PLATELET FUNCTION AND HEMOSTASIS
Clinical and Research Applications of Markers of Thrombosis	451	(16)
Manesh R. Patel
Richard C. Becker
Measures of Platelet Activation and Aggregation	467	(20)
Jean-Philippe Collet
Gilles Montalescot
Monocyte-Platelet Aggregates in Patients With Ischemic Heart Disease	487	(10)
Matthew D. Linden
Mark I. Furman
PART VI BIOMARKERS OF DYSLIPIDEMIA AND LIPID MODIFICATION
Measurement of Atherogenic Lipoproteins in Cardiovascular Risk Assessment	497	(22)
Richard L. Dunbar
Daniel J. Rader
Lipoprotein-Associated Phospholipase A2 and Other Lipid-Related Biomarkers in Cardiovascular Disease	519	(26)
Natalie Khuseyinova
Wolfgang Koenig
PART VII CONTEMPORARY AND FUTURE APPLICATIONS OF BIOMARKERS IN CLINICAL CARE
A Multimarker Approach to Evaluation of Patients With Acute Coronary Syndrome	545	(14)
David A. Morrow
Cardiac Biomarkers by Point-of-Care Testing	559	(16)
Paul O. Collinson
Proteomics and Cardiovascular Biomarker Discovery	575	(12)
Emerson Liu
Robert E. Gerszten
Genetic Markers in Cardiovascular Disease	587	(22)
Marc S. Sabatine
Index	609