Cardiovascular Regeneration and Stem Cell Therapy

by Leri, Annarosa; Anversa, Piero; Frishman, William H.

• ISBN13: 9781405148429
• ISBN10: 140514842X
• Edition: 1st
• Format: Hardcover
• Copyright: 2007-04-30
• Publisher: Wiley-Blackwell

Summary

This book is the definitive reference on two of the most exciting areas of cardiovascular research - myocardial regeneration and stem cell therapy - for the treatment of disease. Edited by pioneers in the area, with contributions from every major investigator worldwide, it covers:The biology of stem cells The actions of stem cells from the bone marrow, the heart, and embryos on the normal restorative and repair functions of the heart and blood vessels How stem cells could contribute to myocardial recovery in the face of injury and aging How adjuvant therapy with growth factors might enhance stem cell activity in regeneration and repair Clinical applications and clinical experiencesThis fully referenced publication presents the current state of knowledge in both basic science and clinical practice, and is an essential reference for scientists, students, and clinicians.

Author Biography

Annarosa Leri MD is a lead investigator in the Cardiovascular Research Institute at the New York Medical College where this field of investigation began. She has made major contributions to our understanding of the basic mechanisms involved in stem cell regenerative therapy for the cardiovascular system. Dr. Leri is Professor of Medicine of the Cardiovascular Research Institute of the New York Medical College in Valhalla, New York. She is co-editor and author.

Piero Anversa MD Dr. Anversa is Director of the Cardiovascular Research Institute at New York Medical College, and is the founder of the field of stem cell therapy and regenerative cardiovascular medicine. In recognition of his contributions, Dr. Anversa received the 2004 Distinguished Scientist Award of the American Heart Association.

Professor William H Frishman MD is one of the leading cardiovascular investigators in the world, with emphasis in the area of cardiovascular therapeutics. He is author, co-author, editor and co-editor of 12 textbooks and 800 original articles and chapters. He is currently supplements editor of the American Journal of Medicine, co-editor of the Year Book of Medicine and co-editor-in-chief of the journal Cardiology in Review. Dr. Frishman is the Rosenthal Professor and Chairman of the Department of Medicine at New York Medical College in Valhalla, New York. He is co-editor and co-author.

Table of Contents

Contributors	p. vii
Preface	p. xi
Introduction	p. 1
Stem cell biology	p. 3
Homing of stem cells and tissue injury	p. 5
Adult stem cell plasticity: lineage potential on a continuum	p. 11
Embryonic stem cells and cardiogenesis	p. 25
Mesenchymal stem-cell-derived cardiomyogenic cells	p. 37
Bone marrow cells and vascular growth	p. 47
Progenitor cells and vascular repair	p. 57
Cardiac progenitor cells in the adult heart	p. 67
Cardiac side population cells: phenotype and functional significance	p. 69
Phenotype and function of c-kit[superscript +] derived amplifying myocytes	p. 77
Cardiac stem cells and their niches	p. 87
Activation of the local regenerative system of the heart	p. 95
Progenitor cells and the diseased heart	p. 103
Embryonic stem cells and myocardial regeneration	p. 105
Bone-marrow-derived cells in myocardial repair and regeneration	p. 117
Endothelial progenitor cells and the infarcted heart	p. 129
Cytokines and heart remodeling	p. 139
IGF-1, muscle progenitors, and heart failure	p. 159
Cardiac progenitor cells and heart failure	p. 159
Cardiac stem cells and diabetic cardiomyopath	p. 161
Stem cells and cardiac aging	p. 171
Bioengineered scaffolds: myocytes, endothelial cells and cardiac repair	p. 183
Gene therapy and cellular therapy in cardiac repair	p. 193
Cardiac stem cells and the failing heart	p. 201
Myocardial infarction: risks and hope	p. 211
Future directions	p. 219
Conclusions - future directions	p. 221
Index	p. 225
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