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The most concise and authoritative introduction to the principles of toxicology and how poisons affect the human body now in full colorCasarett & Doull's Essentials of Toxicologyis an easy-to-absorb distillation of the field's gold-standard textCasarett & Doull's Toxicology: The Basic Science of Poisons. Presented in full color for the first time, the book combines an accessible and engaging approach with coverage of essential introductory concepts to provide you with a solid grounding in basic and medical toxicology. Succinct, yet comprehensive, the text covers essential principles, toxicokinetics, how toxic effects are passed on to succeeding generations, how each body system responds to poisons, and the specific effects of a wide range of toxic agents from pesticides to radiation.Features: A complete basic overview of poisons and their clinical management Reflects the expertise of more than fifty renowned contributors A summary of important points is included at the beginning of each chapter and multiple-choice review questions appear at the conclusion Important chapters on forefront topics such as Analytic/Forensic Toxicology, Clinical Toxicology, Occupational Toxicology, Air Pollution, and EcotoxicologyCondensed Table of Contents:General Principles of Toxicology, Disposition of Toxicants, Nonorgan-Directed Toxicity, Target Organ Toxicity, Toxic Agents, Environmental Toxicology, Applications of Toxicology.
Curtis Klaassen, PhD Professor and Chair Department of Pharmacology, Toxicology, and Therapeutics University of Kansas Medical Center Kansas City, Kansas
John Watkins, III, PhD Professor of Pharmacology and Toxicology The Medical Sciences Program Indiana University Bloomington, Indiana
Table of Contents
UNIT 1: GENERAL PRINCIPLES OF TOXICOLOGY; Chapter 1. History and Scope of Toxicology Michael A. Gallo); Chapter 2. Principles of Toxicology (David L. Eaton and Steven G. Gilbert); Chapter 3. Mechanisms of Toxicity (Zoltán Gregus); Chapter 4. Risk Assessment (Elaine M. Faustman and Gilbert S. Omenn); UNIT 2: DISPOSITION OF TOXICANTS; Chapter 5. Absorption, Distribution, and Excretion of Toxicants (Lois D. Lehman-McKeeman); Chapter 6. Biotransformation of Xenobiotics (Andrew Parkinson and Brian W. Ogilvie); Chapter 7. Toxicokinetics (Danny D. Shen); UNIT 3: Nonorgan-Directed Toxicity; Chapter 8. Chemical Carcinogenesis (James E. Klaunig and Lisa M. Kamendulis); Chapter 9. Genetic Toxicology (R. Julian Preston and George R. Hoffmann); Chapter 10. Developmental Toxicology (John M. Rogers and Robert J. Kavlock)l; UNIT 4: TARGET ORGAN TOXICITY; Chapter 11. Toxic Responses of the Blood (John C. Bloom and John T. Brandt); Chapter 12. Toxic Responses of the Immune System (Norbert E. Kaminski, Barbara L. Faubert Kaplan, and Michael P. Holsapple); Chapter 13. Toxic Responses of the Liver (Hartmut Jaeschke); Chapter 14. Toxic Responses of the Kidney (Rick G. Schnellmann); Chapter 15. Toxic Responses of the Respiratory System (Hanspeter R. Witschi, Kent E. Pinkerton, Laura S. Van Winkle, and Jerold A. Last); Chapter 16. Toxic Responses of the Nervous System (Virginia C. Moser, Michael Aschner, Rudy J. Richardson, and Martin A. Philbert); Chapter 17. Toxic Responses of the Ocular and Visual System (Donald A. Fox and William K. Boyes); Chapter 18. Toxic Responses of the Heart and Vascular System (Y. James Kang); Chapter 19. Toxic Responses of the Skin (Robert H. Rice and Theodora M. Mauro); Chapter 20. Toxic Responses of the Reproductive System (Paul M.D. Foster and L. Earl Gray Jr.); Chapter 21. Toxic Responses of the Endocrine System (Charles C. Capen); UNIT 5: TOXIC AGENTS; Chapter 22. Toxic Effects of Pesticides (Lucio G. Costa); Chapter 23. Toxic Effects of Metals (Jie Liu, Robert A. Goyer, and Michael P. Waalkes); Chapter 24. Toxic Effects of Solvents and Vapors (James V. Bruckner and D. Alan Warren); Chapter 25. Toxic Effects of Radiation and Radioactive Materials (Naomi H. Harley); Chapter 26. Toxic Effects of Terrestrial Animal Venoms and Poisons (John B. Watkins, III); Chapter 27. Toxic Effects of Plants, Fungi, and Algae (Stata Norton); UNIT 6: ENVIRONMENTAL TOXICOLOGY; Chapter 28. Air Pollution (Daniel L. Costa); Chapter 29. Ecotoxicology (Richard T. Di Giulio and Michael C. Newman); UNIT 7: APPLICATIONS OF TOXICOLOGY; Chapter 30. Food Toxicology (Frank N. Kotsonis and George A. Burdock); Chapter 31. Analytic/Forensic Toxicology (Alphonse Poklis); Chapter 32. Clinical Toxicology (Louis R. Cantilena, Jr.); Chapter 33. Occupational Toxicology (Peter S. Thorne); Self-Assessment Questions and Answers; Index