This book brings together scientists working at the interface between the cell cycle, cell growth and development in a variety of model systems and research paradigms. The focus is on understanding how such diverse developmental inputs can modulate cell cycle regulation and, reciprocally, how a common way of regulating cell cycle progression can participate in different developmental strategies.

The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.

Introduction

1

(2)

Paul Nurse

Pattern - and growth-linked cell cycles in Drosophila development

3

(16)

Bruce A. Edgar

Jessica Britton

Aida Flor A. de la Cruz

Laura A. Johnston

Dara Lehman

Cristina Martin-Castellanos

David Prober

Discussion

12

(7)

Imprinted genes and the coordination of fetal and postnatal growth in mammals

19

(17)

Wolf Reik

Karen Davies

Wendy Dean

Gavin Kelsey

Miguel Constancia

Discussion

31

(5)

General discussion I

36

(7)

Regulation of the embryonic cell proliferation by Drosophila cyclin D and cyclin E complexes

43

(15)

Christian F. Lehner

Henning W. Jacobs

K. Sauer

Class A. Meyer

Discussion

54

(4)

Cell cycle transitions in early Xenopus development

58

(21)

James L. Maller

Stefan D. Gross

Markus S. Schwab

Carla V. Finkielstein

Frederic E. Taieb

Yue-Wei Qian

Discussion

73

(6)

Cell cycle regulation in early mouse embryos

79

(14)

Jacek Z. Kubiak

Maria A. Ciemerych

Discussion

89

(4)

General discussion II Regulation of Drosophila imaginal disc growth by the insulin/IGF signalling pathway

93

(7)

Timing cell-cycle exit and differentiation in oligodendrocyte development

100

(13)

Martin Raff

Jim Apperly

Toru Kondo

Yasuhito Tokumoto

Dean Tang

Discussion

107

(6)

Splitting the chromosome: cutting the ties that bind sister chromatids

113

(26)

Kim Nasmyth

Jan-Michael Peters

Frank Uhlamann

Discussion

133

(6)

The cell cycle machinery and asymmetric cell division of neural progenitors in the Drosophila embryonic central nervous system

139

(19)

William Chia

Yu Cai

Xavier Morin

Murni Tio

Gerald Udolph

Fengwei Yu

Xiaohand Yang

Discussion

151

(7)

General discussion III Determining organ size

158

(6)

Spindle positioning during the asymmetric first cell division of Caenorhabditis elegans embryos

164

(18)

Pierre Gonczy

Stephan Grill

Ernst H. K. Stelzer

Matthew Kirkham

Anthony A. Hyman

Discussion

176

(6)

Growth factors controlling imaginal disc growth in Drosophila

182

(18)

Peter J. Bryant

Discussion

194

(6)

General discussion IV Spatial organization and the cell cycle

200

(3)

The temporal control of cell cycle and cell fate in Caenorhabiditis elegans

203

(18)

Victor Ambros

Discussion

214

(7)

Responses to DNA damage in Xenopus: cell death or cell cycle arrest

221

(14)

Jessica Greenwood

Vincenzo Costanzo

Kirsten Robertson

Carmel Hensey

Jean Gautier

Discussion

230

(5)

Control of cell fate in plant meristems

235

(13)

Martin Hobe

Ulrike Brand

Richard Waites

Rudiger Simon

Discussion

243

(5)

Final discussion

248

(4)

Index of contributors

252

(2)

Subject index

254

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