The Cell Cycle an Introduction

by Murray, Andrew; Hunt, Tim

• ISBN13: 9780195095296
• ISBN10: 0195095294
• Format: Paperback
• Copyright: 1993-09-23
• Publisher: Oxford University Press

Summary

In the last decade there has been a revolution in our comprehension of how cells grow and divide. Results from experiments on yeast, embryos, and cultured mammalian cells have unified seemingly disparate viewpoints into a single set of principles for normal cellular reproduction in plants, animals and bacteria. Written by two leading participants in that revolution,The Cell Cycleprovides the first thorough, authoritative account of the new philosophy of normal cellular reproduction and how it emerged. It is a vivid portrayal of the molecular logic of the cell: how the cell engine induces DNA replication and chromosome replication; how the integrity of genetic information is preserved; and how cell size and environmental signals regulate the cycle of growth and division. By describing important breakthroughs in their historical and experimental context,The Cell Cycletraces the development of the new vision of cell biology and shows its relevance to other areas of modern biology. It is the ideal introduction to the current understanding of cell growth and division for advanced undergraduate and graduate level cell biology courses.

Author Biography

Andrew Murray is Assistant Professor of Physiology at the University of California, San Francisco. Tim Hunt is at ICRF Clare Hall Laboratories, Hertfordshire, UK, and is Professor in the Department of Biochemistry at Cambridge University.

Table of Contents

PREFACE	ix	(2)
NOTE ON GENETIC NOMENCLATURE	xi
INTRODUCTION	1	(2)
1 CELLS AND THE CELL CYCLE	3	(13)
Basic Properties of Cells	4	(3)
Basic Properties of the Cell Cycle	7	(5)
Approaches to the Cell Cycle	12	(4)
2 THE EARLY EMBRYONIC CELL CYCLE	16	(12)
Embryonic Cell Cycles	18	(4)
The Cell Cycle Engine	22	(6)
3 GENETIC ANALYSIS OF THE CELL CYCLE	28	(14)
Cell Division Cycle Mutants	30	(2)
Start	32	(10)
4 ENZYMES THAT CONTROL MITOSIS	42	(24)
Control of Mitosis in Fission Yeast	42	(8)
A Universal Cell Cycle Engine	50	(2)
Cyclin and the Cell Cycle	52	(4)
Post-Translational Regulation of Mitosis	56	(10)
5 MITOSIS	66	(23)
Nuclear Envelope Breakdown	68	(3)
Chromatin Condensation	71	(3)
Microtubules, Microtubule Motors, and Kinetochores	74	(6)
Spindle Assembly	80	(3)
Anaphase	83	(6)
6 THE TRANSITION FROM G 1 TO S PHASE	89	(28)
Start Control in Budding Yeast	90	(10)
Growth Control in Mammalian Cells	100	(6)
The Molecular Basis of Growth and Proliferation Control in Mammalian Cells	106	(11)
7 THE CONTROL OF DNA REPLICATION	117	(18)
Activation of the Replication Machinery	118	(3)
Microtubule Organizing Center Duplication	121	(3)
The Block to Rereplication	124	(11)
8 CHECKPOINTS AND FEEDBACK CONTROLS	135	(18)
Checkpoints, Feedback Controls, and Relative Timing	136	(3)
Control of Entry into Mitosis	139	(8)
Control of Exit from Mitosis	147	(6)
9 CANCER	153	(14)
Oncogenes and Tumor Suppressor Genes	154	(7)
Cancer and Feedback Controls	161	(6)
10 THE MEIOTIC CELL CYCLE	167	(16)
Recombination	168	(4)
Meiotic Chromosome Segregation	172	(5)
Checkpoints in Meiosis	177	(6)
11 THE BACTERIAL CELL CYCLE	183	(18)
Organization of the Bacterial Cell Cycle	184	(6)
DNA Replication	190	(3)
Chromosome Segregation and Septation	193	(8)
APPENDIX: GENES THAT AFFECT THE CELL CYCLE	201	(44)
Budding Yeast	201	(26)
Fission Yeast	227	(11)
Aspergillus	238	(2)
Index to Genes That Affect the Cell Cycle	240	(5)
INDEX	245