Cell Physiology Source Book : A Molecular Approach

by Nicholas Sperelakis

• ISBN13: 9780126569711
• ISBN10: 0126569711
• Format: Paperback
• Copyright: 1996-01-01
• Publisher: HBC ACAD

Summary

A multi-authored and comprehensive text, Cell Physiology Source Book enables graduate students in various biological sub-disciplines to gain a thorough understanding of cell physiology. It begins with a reviewof the physical chemistry of solutions, protein structure, and membrane structure, and ends with an Appendix featuring reviews of electricity, electrochemistry, and cable properties of cells. In between, this book is loaded with information on membrane potentials, cell metabolism, signal transduction, transport physiology and pumps, membrane excitability and ion channels, synaptic transmission, sensory transduction, muscle contraction, excitation-contraction coupling, bioluminescence, photosynthesis, andplant cell physiology. This exhaustive work provides graduate students with detailed and authoritative coverage of nearly all aspects of cell physiology. Such broad coverage of this field within a single source makes for a unique text. Chapters written in a clear, concise, and didactic style, and appropriate reviews of basic physics and chemistry are among the many distinguishing features of this monumental treatise. Comprehensive source-book of cell physiology Authoritative and multi-authored by leading experts in the field Unique features include broad coverage and review of relevant physics, chemistry, and metabolism Clear, concise, and didactic Includes reviews of physical chemistry of solutions, protein structure, membrane structure, electrochemistry, and electricity Topic covered include plant cell physiology, photosynthesis, bioluminescence, effects of pressure, cilia, and flagellae Detailed treatise on ion channels and their regulation

Table of Contents

Contributors	p. xi
Foreword to the first Edition	p. xv
Foreword to the Second Edition	p. xvii
Foreword to the Third Edition	p. xix
Preface to the First Edition	p. xxi
Preface to the Second Edition	p. xxiii
Preface to the Third Edition	p. xxv
Biophysical Chemistry, Metabolism, Second Messengers, and Ultrastructure
Biophysical Chemistry of Physiological Solutions	p. 3
Thermodynamics of Membrane Transport	p. 16
Physiological Structure and Function of Proteins	p. 19
Structural Organization and Properties of Membrane Lipids	p. 43
Cell Membranes and Model Membranes	p. 65
Lipid Domains and Biological Membrane Function	p. 81
Ultrastructure of Cells	p. 95
Energy Production and Metabolism	p. 119
Physiology of Mitochondria	p. 139
Signal Transduction	p. 153
Calcium as an Intracellular Second Messenger: Mediation by Calcium-Binding Proteins	p. 167
Regulation of Cellular Functions by Extracellular Calcium	p. 179
Cellular Responses to Hormones	p. 191
Membrane Potential, Transport Physiology, Pumps, and Exchangers
Diffusion and Permeability	p. 209
Exponential Time Course of Diffusion	p. 217
Origin of Resting Membrane Potentials	p. 219
Appendix	p. 237
Gibbs-Donnan Equilibrium Potentials	p. 243
Mechanisms of Carrier-Mediated Transport: Facilitated Diffusion, Cotransport, and Countertransport	p. 249
Sodium Pump Function	p. 261
Ca[superscript 2+]-ATPases	p. 271
Na[superscript +]-Ca[superscript 2+] Exchange Currents	p. 283
Intracellular Chloride Regulation	p. 301
Osmosis and Regulation of Cell Volume	p. 319
Intracellular pH Regulation	p. 357
Techniques for pH Measurement	p. 373
Membrane Transport in Red Blood Cells	p. 377
Membrane Excitability and Ion Channels
Cable Properties and Propagation of Action Potentials	p. 395
Propagation in Cardiac Muscle and Smooth Muscles	p. 407
Derivation of the Cable Equation and the AC Length Constant	p. 412
Electrogenesis of Membrane Excitability	p. 417
Patch-Clamp Techniques and Analysis	p. 441
Structure and Mechanism of Voltage-Gated Ion Channels	p. 455
Biology of Neurons	p. 479
Ion Channels in Nonexcitable Cells	p. 485
Ion Channels in Sperm	p. 509
Biology of Gap Junctions	p. 523
Biophysics of the Nuclear Envelope	p. 539
Regulation of Ion Channels by Phosphorylation	p. 559
Direct Regulation of Ion Channels by G Proteins	p. 573
Developmental Changes in Ion Channels	p. 585
Regulation of Ion Channels by Membrane Proteins and Cytoskeleton	p. 601
Ion Channels as Targets for Toxins, Drugs, and Genetic Diseases
Ion Channels as Targets for Toxins	p. 625
Ion Channels as Targets for Drugs	p. 643
Ion Channels as Targets for Disease	p. 653
Synaptic Transmission and Sensory Transduction
Ligand-Gated Ion Channels	p. 675
Synaptic Transmission	p. 689
Excitation-Secretion Coupling	p. 705
Stimulus-Response Coupling in Metabolic Sensor Cells	p. 725
Mechanosensitive Ion Channels in Eukaryotic Cells	p. 745
Sensory Receptors and Mechanotransduction	p. 761
Acoustic Transduction	p. 775
Self-Referencing Electrodes for the Measurement of Extracellular Potential and Chemical Gradients	p. 792
Cyclic Nucleotide-Gated Ion Channels	p. 795
Visual Transduction	p. 807
Gustatory and Olfactory Sensory Transduction	p. 815
Infrared Sensory Organs	p. 832
Electroreceptors and Magnetoreceptors	p. 839
The Biophysics of Electroreception in Ampullary Organs of Elasmobranch Fishes	p. 857
Muscle and Other Contractile Systems
Skeletal Muscle Action Potentials	p. 865
Cardiac Action Potentials	p. 887
Smooth Muscle Action Potentials and Electrical Profiles	p. 899
Excitation-Contraction Coupling in Skeletal Muscle	p. 911
Ca[superscript 2+] Release from Sarcoplasmic Reticulum in Muscle	p. 927
Contraction of Muscles	p. 941
Amoeboid Movement, Cilia, and Flagella	p. 959
Centrin-Based Contraction and Bacterial Flagella	p. 985
Effects of High Pressure on Cellular Processes	p. 1003
Electrocytes of Electric Fish	p. 1025
Protozoa and Bacteria
Physiological Adaptations of Protists	p. 1041
Physiology of Prokaryotic Cells	p. 1063
Plant Cells, Photosynthesis, and Bioluminescence
Plant Cell Physiology	p. 1079
Photosynthesis	p. 1097
Bioluminescence	p. 1115
Cell Division and Programmed Cell Death
Regulation of Cell Division in Higher Eukaryotes	p. 1135
Cancer Cell Properties	p. 1161
Apoptosis	p. 1171
Effects of Ionizing Radiation on Cells	p. 1185
Appendix
Review of Electricity and Cable Properties	p. 1205
Index	p. 1221
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