The Cellular Basis of Central Nervous System HIV-1 Infection and the AIDS Dementia Complex

by Price; Richard W

• ISBN13: 9781560247746
• ISBN10: 1560247746
• Edition: 1st
• Format: Hardcover
• Copyright: 1996-02-09
• Publisher: Routledge

Summary

In this exciting symposium, the editor brings to print important new information on AIDS and how HIV affects the brain. Each chapter focuses on one or more of the cell types that reside in or traffic through the central nervous system (CNS). Each of these cells is important to considerations of the pathogenesis of the CNS. Neurologists, AIDS physicians, and other professionals caring for AIDS patients will find that this "cell-based" view provides a unique perspective and that it will guide and stimulate future investigation of this clinically important and pathogenetically intriguing disorder. The editor also introduces some general considerations for therapeutic intervention of AIDS dementia complex (ADC). The contributors to The Cellular Basis of Central Nervous System HIV-1 Infection and the AIDS Dementia Complex deal with the cells and mechanisms involved in HIV-1 brain infection and the resultant ADC. Each author was asked to review the involvement of their assigned cells in CNS HIV-1 infection and how these cells might be involved in the pathology and process of brain injury associated with ADC. Readers will be enlightened on the functional roles of various cells and how these cells and mechanisms might fit into the broader picture of ADC pathogenesis.

Table of Contents

The Cellular Basis of Central Nervous System HIV-1 Infection and the AIDS Dementia Complex: Introduction	1	(30)
Richard W. Price
Traffic of Lymphocytes into the CNS During Inflammation and HIV Infection	31	(26)
Kenneth C. Williams
William F. Hickey
Microglia in HIV-Related CNS Neuropathology: An Update	57	(28)
Dennis W. Dickson
Sunhee C. Lee
HIV Infection of the Brain Microvasculature and Its Contribution to the AIDS Dementia Complex	85	(16)
Ashlee V. Moses
Stephan G. Stenglein
Jay A. Nelson
Ependyma and Choroid Plexus	101	(10)
Carol K. Petito
Astrocytes and the AIDS Dementia Complex	111	(22)
Holly K. Patton
Etty N. Benveniste
Dale J. Benos
Cellular Basis of HIV Infection of the CNS and the AIDS Dementia Complex: Oligodendrocyte	133	(28)
Margaret M. Esiri
Christine S. Morris
Patterns of Neurodegeneration in HIV Encephalitis	161	(14)
Eliezer Masliah
Nianfeng Ge
Cristian L. Achim
Richard DeTeresa
Clayton A. Wiley
Index	175