Cellular and Molecular Physiology of Sodium-Calcium Exchange : Proceedings of the Fourth International Conference

by Lytton, Jonathan; Schnetkamp, Paul P. M.; Hryshko, Larry V.; Blaustein, M. P.

• ISBN13: 9781573313865
• ISBN10: 1573313866
• Edition: 1st
• Format: Hardcover
• Copyright: 2002-11-01
• Publisher: New York Academy of Sciences

Table of Contents

Preface	xiii
Jonathan Lytton
Keynote Address
The Na+/Ca2+ Exchange Molecule: An Overview	1	(10)
Kenneth D. Philipson
Debora A. Nicoll
Michela Ottolia
Beate D. Quednau
Hannes Reuter
Scott John
Zhiyong Qiu
Part I. Molecular Physiology
Toward a Topological Model of the NCX1 Exchanger	11	(8)
Debora A. Nicoll
Michela Ottolia
Kenneth D. Philipson
Probing Ion Binding Sites in the Na+/Ca2+ Exchanger	19	(12)
Munekazu Shigekawa
Takahiro Iwamoto
Akira Uehara
Satomi Kita
Ion Channel-like Properties of the Na+/K+ Pump	31	(10)
Pablo Artigas
David C. Gadsby
The Na/Ca-K Exchanger Gene Family	41	(12)
Robert T. Szerencsei
Robert J. Winkfein
Conan B. Cooper
Clemens Prinsen
Tashi G. Kinjo
Kyeongjin Kang
Paul P.M. Schnetkamp
Poster Papers
Toward Comparative Genomics of Calcium Transporters	53	(7)
Alexander Kraev
David H. MacLennan
Sodium-Calcium Exchanger NCX1, NCX2, and NCX3 Transcripts in Developing Rat Brain	60	(4)
S.K. Polumuri
A. Ruknudin
Margaret M. McCarthy
Tara S. Perrot-Sinal
D.H. Schulze
Differential Expression of Na/Ca Exchanger and Na/Ca+K Exchanger Transcripts in Rat Brain	64	(3)
Xiao-Fang Li
Jonathan Lytton
Sodium-Calcium Exchangers in Olfactory Tissue	67	(6)
D.H. Schulze
M. Pyrski
A. Ruknudin
J.W. Margolis
S.K. Polumuri
F.L. Margolis
Molecular Identification of the NCX Isoform Expressed in Tracheal Smooth Muscle of Guinea Pig	73	(4)
R. Mejia-Elizondo
R. Espinosa-Tanguma
V.M. Saavedra-Alanis
Localization and Molecular Characterization of the Crayfish NCX	77	(4)
L.M. Stiner
Z. Zhang
M.G. Wheatly
Characterization and Functional Activity of a Truncated Na/Ca Exchange Isoform Resulting from a New Splicing Pattern of NCX1	81	(4)
Francoise Van Eylen
Adama Kamagate
Andre Herchuelz
Activation of the Cardiac Na+/Ca2+ Exchanger by DEPC	85	(4)
Michela Ottolia
Sabrina Schumann
Debora A. Nicoll
Kenneth D. Philipson
Cysteine Residues Are Important for Functional Expression of the Na+/Ca2+ Exchanger NCX1 in HEK 293 Cells	89	(1)
Xiaoyan Ren
Judith Kasir
Hannah Rahamimoff
Topological Studies of the Rat Brain K+-Dependent Na+/Ca2+ Exchanger NCKX2	90	(4)
Xinjiang Cai
Kathy Zhang
Jonathan Lytton
Studies on the Oligomeric State of the Sodium/Calcium+Potassium Exchanger NCKX2	94	(3)
Seunghwa Sally Yoo
Stephen Leach
Jonathan Lytton
Conformational Changes of the 120-kDa Na+/Ca2+ Exchanger Protein upon Ligand Binding: A Fourier Transform Infrared Spectroscopy Study	97	(3)
Rami I. Saba
Erik Goormaghtigh
Jean-Marie Ruysschaert
Andre Herchuelz
Sodium--Calcium Exchange Crystallization	100	(3)
Calvin C. Hale
Julie Bossuyt
Chananada K. Hill
Elmer M. Price
Dan H. Schulze
Jon W. Lederer
Roberto Poljak
Bradford C. Braden
Proteomics Approach to Na+/Ca2+ Exchangers in Prokaryotes	103	(6)
A. Ruknudin
D.H. Schulze
Temperature Dependence of Cardiac Na+/Ca2+ Exchanger	109	(4)
Christian Marshall
Chadwick Elias
Xiao-Hua Xue
Hoa Dinh Le
Alexander Omelchenko
Larry V. Hryshko
Glen F. Tibbits
The Ca/Ca Exchange Mode of the Na/Ca Exchanger Investigated by Photolytic Ca2+ Concentration Jumps	113	(4)
Andreas Haase
Michael Kappl
Georg Nagel
Philip G. Wood
Klaus Hartung
Functional Analysis of Polar Residues Important for Activity of Na+/H+ Exchangers	117	(4)
Larry Fliegel
Christine Wiebe
Rakhilya Murtazina
Pavel Dibrov
Brenda J. Booth
Bonnie L. Bullis
Emily DiBattista
Dyal N. Singh
Part II. Stoichiometry
Stoichiometry of the Na+/Ca2+ Exchanger: Models and Implications	121	(12)
Satoshi Matsuoka
Influence of Na/Ca Exchange Stoichiometry on Model Cardiac Action Potentials	133	(4)
Denis Noble
Rat Heart NCX1.1 Stoichiometry Measured in a Transfected Cell System	137	(5)
Jonathan Lytton
Hui Dong
Sodium-Calcium Exchange Stoichiometry: Is The Noose Tightening?	142	(10)
Tong Mook Kang
Mark Steciuk
Donald William Hilgemann
Stoichiometry: A Discussion	152	(2)
Poster Papers
Reexamination of the Stoichiometry of Na+/Ca2+ Exchange with Whole-Cell Voltage Clamp of Guinea Pig Ventricular Myocytes	154	(3)
Masamitsu Hinata
Hisao Yamamura
Libing Li
Yasuhide Watanabe
Tomokazu Watano
Yuji Imaizumi
Junko Kimura
Simultaneous Measurement of [Na]i, [Ca]i, and INCX in Intact Cardiac Myocytes	157	(2)
Kenneth S. Ginsburg
Christopher R. Weber
Sanda Despa
Donald M. Bers
Electrophysiological Studies of the Cloned Rat Cardiac NCX1.1 in Transfected HEK Cells: A Focus on the Stoichiometry	159	(7)
Hui Dong
Jeremy Dunn
Jonathan Lytton
Part III. Functional Regulation
Tissue-Specific Modes of Na/Ca Exchanger Regulation	166	(10)
Larry V. Hryshko
NCX1 Surface Expression: A Tool to Identify Structural Elements of Functional Importance	176	(11)
Hannah Rahamimoff
Xiaoyan Ren
Chava Kimchi-Sarfaty
Suresh Ambudkar
Judith Kasir
Functional Regulation of Alternatively Spliced Na+/Ca2+ Exchanger (NCX1) Isoforms	187	(10)
D.H. Schulze
S.K. Polumuri
T. Gille
A. Ruknudin
The Cardiac Sodium-Calcium Exchanger Associates with Caveolin-3	197	(8)
Julie Bossuyt
Bonnie E. Taylor
Marilyn James-Kracke
Calvin C. Hale
Poster Papers
Kinetic Model of Transport and Regulation of the Cardiac, Brain, and Kidney Isoforms of NCX1	205	(4)
Alexander Omelchenko
Chadwick L. Elias
Robert Scatliff
Platon Choptiany
Mark Hnatowich
Larry V. Hryshko
Phosphorylation of the Na+/Ca2+ Exchangers by PKA	209	(5)
A. Ruknudin
D.H. Schulze
Part IV. Cellular Regulation
Cellular Regulation of Sodium-Calcium Exchange	214	(10)
Madalina Condrescu
Kwabena Opuni
Basil M. Hantash
John P. Reeves
Intracellular Ionic and Metabolic Regulation of Squid Nerve Na+/Ca2+ Exchanger	224	(13)
Reinaldo Dipolo
Luis Beauge
Pathways Regulating Na+/Ca2+ Exchanger Expression in the Heart	237	(11)
Donald R. Menick
Lin Xu
Christiana Kappler
Wenjing Jiang
Patrick R. Withers
Neal Shepherd
Simon J. Conway
Joachim G. Muller
Multiple Modes of Regulation of Na+/H+ Exchangers	248	(11)
Hisayoshi Hayashi
Katalin Szaszi
Sergio Grinstein
Cyclosporin A Regulates Sodium-Calcium Exchanger (NCX1) Gene Expression in Vitro and Cardiac Hypertrophy in NCX1 Transgenic Mice	259	(9)
Maria C. Jordan
Beate D. Quednau
Kenneth P. Roos
Robert S. Ross
Kenneth D. Philipson
Susanne B. Nicholas
Role of Sodium-Calcium Exchanger (Ncx1) in Embryonic Heart Development: A Transgenic Rescue?	268	(14)
Simon J. Conway
Agnieszka Kruzynska-Frejtag
Jian Wang
Rhonda Rogers
Paige L. Kneer
Hongmei Chen
Tony Creazzo
Donald R. Menick
Srinagesh V. Koushik
Poster Papers
The Gene Promoter of Human Na+/Ca2+ Exchanger Isoform 3 (SLC8A3) Is Controlled by cAMP and Calcium	282	(3)
Nadia Gabellini
Stefania Bortoluzzi
Gian A. Danieli
Ernesto Carafoli
Role of MAP Kinases in the Na+/Ca2+ Exchanger Gene Expression in Feline Adult Cardiocytes	285	(3)
Lin Xu
Joachim G. Muller
Patrick R. Withers
Christiana Kappler
Wenjing Jiang
Donald R. Menick
Part V. Calcium Homeostasis
Regulation of Phosphatidylinositol-4,5-Bisphosphate Bound to the Bovine Cardiac Na+/Ca2+ Exchanger	288	(12)
Luis Beauge
Carla Asteggiano
Graciela Berberian
Potassium-Dependent Sodium-Calcium Exchange through the Eye of the Fly	300	(15)
R. Webel
K. Haug-Collet
B. Pearson
R.T. Szerencsei
R.J. Winkfein
P.P.M. Schnetkamp
N.J. Colley
Na/Ca Exchange in Function, Growth, and Demise of β-Cells	315	(10)
Andre Herchuelz
Oscar Diaz-Horta
Francoise Van Eylen
Binding of the Retinal Rod Na+/Ca2+-K+ Exchanger to the cGMP-Gated Channel Indicates Local Ca2+-Signaling in Vertebrate Photoreceptors	325	(10)
Paul J. Bauer
Poster Papers
Exercise Training Enhances Coronary Smooth Muscle Cell Sodium-Calcium Exchange Activity in Diabetic Dyslipidemic Yucatan Swine	335	(3)
E.A. Mokelke
M. Wang
M. Sturek
Dysregulation of [Ca2+]i in OK-PTH Cells Expressing a Mesangial Cell Na+/Ca2+ Exchanger Isoform from Dahl/Rapp Salt-Sensitive Rats	338	(4)
T. Unlap
E. Hwang
G. Kovacs
J. Peti-Peterdi
B. Siroky
I. Williams
P.D. Bell
Enhanced Susceptibility of a Na+/Ca2+ Exchanger Isoform from Mesangial Cells of Salt-Sensitive Dahl/Rapp Rats to Oxidative Stress Inactivation	342	(3)
T. Unlap
E.H. Hwang
B.J. Siroky
J. Peti-Peterdi
G. Kovacs
I. Williams
P.D. Bell
Reverse Mode Na+/Ca2+ Exchange in the Collagen Activation of Human Platelets	345	(5)
Diane E. Roberts
Ratna Bose
Na+/Ca2+ Exchange in Activated and Nonactivated Human Platelets	350	(4)
Ratna Bose
Yun Li
Diane Roberts
Effect of Glucose on the Expression Level of the Plasma Membrane Ca2+-ATPase and the Na+/Ca2+ Exchanger in Pancreatic Islet Cells	354	(2)
Helena Maria Ximenes
Adama Kamagate
Francoise Van Eylen
Andre Herchuelz
Part VI. Neuronal Function
Na/Ca Exchanger and PMCA Localization in Neurons and Astrocytes: Functional Implications	356	(11)
M.P. Blaustein
M. Juhaszova
V.A. Golovina
P.J. Church
E.F. Stanley
Immunohistochemical Detection of the Sodium-Calcium Exchanger in Rat Hippocampus Cultures Using Subtype-Specific Antibodies	367	(9)
T. Thurneysen
D.A. Nicoll
K.D. Philipson
H. Porzig
A Study of the Activity of the Plasma Membrane Na/Ca Exchanger in the Cellular Environment	376	(6)
Marisa Brini
Sabrina Manni
Ernesto Carafoli
K+-Dependent Na+/Ca2+ Exchangers in the Brain	382	(12)
Jonathan Lytton
Xiao-Fang Li
Hui Dong
Alexander Kraev
Brain Distribution of the Na+/Ca2+ Exchanger-Encoding Genes NCX1, NCX2, and NCX3 and Their Related Proteins in the Central Nervous System	394	(11)
Adriana Canitano
Michele Papa
Francesca Boscia
Pasqualina Castaldo
Stefania Sellitti
Maurizio Taglialatela
Lucio Annunziato
Poster Papers
Neurotransmitter-Induced Activation of Sodium-Calcium Exchange Causes Neuronal Excitation	405	(3)
Krister S. Eriksson
Olga A. Sergeeva
David R. Stevens
Helmut L. Haas
Na+/Ca2+ Exchanger in Na+ Efflux-Ca2+ Influx Mode of Operation Exerts a Neuroprotective Role in Cellular Models of in Vitro Anoxia and in Vivo Cerebral Ischemia	408	(5)
A. Tortiglione
G. Pignataro
M. Minale
A. Secondo
A. Scorziello
G.F. Di Renzo
S. Amoroso
G. Caliendo
V. Santagada
L. Annunziato
Mitochondria Buffer Sodium-Dependent Ca2+ Influx in Cultured Cerebellar Granule Cells	413	(5)
Lech Kiedrowski
Aneta Czyz
ATP Stimulation of Na+/Ca2+ Exchanger in Bovine Brain Membrane Vesicles Is Similar to That of the Heart and Independent of Ionic Strength of Assay or Preparation	418	(3)
Graciela Berberian
Carla Asteggiano
Cuong Pham
Part VII. Na/Ca Exchanger Function in Disease
Is Na/Ca Exchange during Ischemia and Reperfusion Beneficial or Detrimental?	421	(10)
Elizabeth Murphy
Heather R. Cross
Charles Steenbergen
Simulation of Na/Ca Exchange Activity during Ischemia	431	(7)
Denis Noble
Role of the Na/Ca Exchanger in Arrhythmias in Compensated Hypertrophy	438	(8)
Karin R. Sipido
Paul G. A. Volders
Marieke Schoenmakers
S. H. Marieke De Groot
Fons Verdonck
Marc A. Vos
Enhanced Sodium--Calcium Exchange in the Infarcted Heart: Effects on Sarcoplasmic Reticulum Content and Cellular Contractility	446	(8)
Sheldon E. Litwin
Dongfang Zhang
Na/Ca Exchange in Heart Failure: Contractile Dysfunction and Arrhythmogenesis	454	(12)
Steven M. Pogwizd
Donald M. Bers
Modulation of Contractility in Failing Human Myocytes by Reverse-Mode Na/Ca Exchange	466	(6)
Valentino Piacentino III
Christopher R. Weber
John P. Gaughan
Kenneth B. Margulies
Donald M. Bers
Steven R. Houser
Poster Papers
Decreased β-Adrenergic Responsiveness of Na/Ca Exchange Current in Failing Pig Myocytes	472	(4)
Shao-Kui Wei
Stephen U. Hanlon
Mark C.P. Haigney
Ca Influx via the Na/Ca Exchanger Maintains Sarcoplasmic Reticulum Ca Content in Failing Human Myocytes	476	(2)
Valentino Piacentino III
Kenneth B. Margulies
Steven R. Houser
Calcium Influx via INCX Is Favored in Failing Human Ventricular Myocytes	478	(2)
Christopher R. Weber
Valentino Piacentino III
Kenneth B. Margulies
Donald M. Bers
Steven R. Houser
Overexpression of Na+/Ca2+ Exchanger Attenuates Postinfarcted Myocardial Dysfunction	480	(3)
Jiang-Yong Min
Matthew F. Sullivan
Victor Chu
Ju-Feng Wang
Ivo Amende
James P. Morgan
Kenneth D. Philipson
Thomas G. Hampton
Ischemic Tolerance of Homozygous Transgenic Mouse Hearts Overexpressing the Sodium-Calcium Exchanger	483	(4)
Malcolm M. Bersohn
Cecil R. Carmack
Kenneth D. Philipson
Na/Ca Exchanger Overexpression Induces Endoplasmic Reticulum-Related Apoptosis and Caspase-12 Release	487	(1)
O. Diaz-Horta
A. Herchuelz
F. Van Eylen
Part VIII. Cardiac Physiology and Pathophysiology
The Molecular Architecture of Calcium Microdomains in Rat Cardiomyocytes	488	(12)
David R. L. Scriven
Agnieszka Klimek
Kelly L. Lee
Edwin D. W. Moore
Na/Ca Exchange Function in Intact Ventricular Myocytes	500	(13)
Donald M. Bers
Christopher R. Weber
Pharmacology of Na+/Ca2+ Exchanger	513	(7)
Junko Kimura
Yasuhide Watanabe
Libing Li
Tomokazu Watano
Functional Consequences of Na/Ca Exchanger Overexpression in Cardiac Myocytes	520	(8)
Cesare Terracciano
Poster Papers
Na+/Ca2+ Exchanger Is Functional in Both Ca2+ Influx and Efflux Modes in Rat Myocytes	528	(2)
Xue-Qian Zhang
Jianliang Song
George M. Tadros
Lawrence I. Rothblum
Jeremy Dunn
Jonathan Lytton
Joseph Y. Cheung
Volatile Anesthetics and Regulation of Cardiac Na+/Ca2+ Exchange in Neonates versus Adults	530	(5)
Y. S. Prakash
Larry W. Hunter
Inanc Seckin
Gary C. Sieck
Modulation of the Na+/Ca2+ Exchanger by Isoprenaline, Adenosine, and Endothelin-1 in Guinea Pig Ventricular Myocytes	535	(4)
Yin Hua Zhang
Annabel K. Hinde
Andrew F. James
Jules C. Hancox
Effect of KB-R7943 on Oscillatory Na+/Ca2+ Exchange Current in Guinea Pig Ventricular Myocytes	539	(4)
Libing Li
Junko Kimura
Inhibition of the Drosophila Na+/Ca2+ Exchanger, CALX1.1, by KB-R7943	543	(4)
Michael R. Isaac
Chadwick L. Elias
Hoa D. Le
Alexander Omelchenko
Mark Hnatowich
Larry V. Hryshko
Index of Contributors	547