Cerebellar Modules: Molecules, Morphology, and Function

by Gerrits; Ruigrok; De Zeeuw

• ISBN13: 9780444501080
• ISBN10: 0444501088
• Edition: 1st
• Format: Hardcover
• Copyright: 2000-07-20
• Publisher: Elsevier Science

Summary

The present volume of Progress in Brain Research contains the proceedings of a Symposium entitled Cerebellar Modules: Molecules, Morphology and Function, which was held to mark the retirement of Jan Voogd as chairman of the Department of Anatomy at the Erasmus University of Rotterdam. The contributions of leading cerebellar scientists representing a variety of disciplines focussed around the issue of the cerebellar modular compartmentalization, the intriguing composition of which has for many decades been the driving force behind Voogd's extraordinarily detailed anatomical analyses. The first section of the book, Development, concentrates on the genetic basis of different aspects of compartmentalized development including a most important contribution on the postnatal development of the climbing fiber system. Gene expression is also an important element in the next section, Interneurons, which provides striking new data and hypotheses on the functional anatomy of granule cells, Golgi cells and unipolar brush cells. Particularly interesting are several contributions that offer a novel view on parallel fiber function. The section Modules and Circuits provides a number of state-of-the-art analyses using electrophysiological, and classical and transneuronal virus tracing techniques. The emphasis lies on the olivocerebellar circuits and the oculomotor system The final section, Models and Learning, offers an insight into the progress on the mechanisms and network organization of adaptation and learning, not only in classical paradigms like oculomotor and eye blink responses but also in studies linking gene expression to behavioral paradigms The editors are confident that the exciting data and concepts collected in this volume will strengthen the multidisciplinary approach in the field of cerebellar research.

Table of Contents

List of contributors	v
List of participants	ix
Preface	xiii
Acknowledgements	xv
I. Development
Neuroepithelial `compartments' and the specification of vestibular projections	3	(20)
J.C. Glover
Antero-posterior boundaries and compartments in the cerebellum: evidence from selected neurological mutants	23	(8)
L.M. Eisenman
Climbing fiber synapse elimination during postnatal cerebellar development requires signal transduction involving Gαq and phospholipase Cβ4	31	(20)
K. Hashimoto
M. Watanabe
H. Kurihara
S. Offermanns
H. Jiang
Y. Wu
K. Jun
H.-S. Shin
Y. Inoue
D. Wu
M.I. Simon
M. Kano
II. Interneurons
Lineage, development and morphogenesis of cerebellar interneurons	51	(18)
K. Schilling
Transgenic methods for directing gene expression to specific neuronal types: cerebellar granule cells	69	(12)
A. Jones
M. Paterlini
W. Wisden
D. Merlo
The function of cerebellar Golgi cells revisited	81	(14)
E. De Schutter
B. Vos
R. Maex
Precise spike timing of tactile-evoked cerebellar Golgi cell responses: a reflection of combined mossy fiber and parallel fiber activation?	95	(12)
B.P. Vos
A. Volny-Luraghi
R. Maex
E. De Schutter
Unravelling cerebellar circuitry: an optical imaging study	107	(8)
D. Cohen
Y. Yarom
Electrotonic coupling synchronizes interneuron activity in the cerebellar cortex	115	(8)
P. Mann-Metzer
Y. Yarom
Unipolar brush cells of the vestibulocerebellum: afferents and targets	123	(18)
M.R. Dino
M.G. Nunzi
R. Anelli
E. Mugnaini
III. Modules and circuits
Topography of cerebellar nuclear projections to the brain stem in the rat	141	(32)
T.M. Teune
J. van der Burg
J. van der Moer
J. Voogd
T.J.H. Ruigrok
The entire trajectory of single climbing and mossy fibers in the cerebellar nuclei and cortex	173	(14)
Y. Shinoda
I. Sugihara
H.-S. Wu
Y. Sugiuchi
Micro-organisation of cerebellar modules controlling forelimb movements	187	(14)
M. Garwicz
Gating of climbing fibre input to cerebellar cortical zones	201	(12)
R. Apps
GABAergic modulation of olivary oscillations	213	(8)
A. Devor
Y. Yarom
Analysis of the discharge pattern of floccular Purkinje cells in relation to vertical head and eye movement in the squirrel monkey	221	(14)
Y. Hirata
S.M. Highstein
IV. Models and learning
Hypotheses about the neural trigger for plasticity in the circuit for the vestibulo-ocular reflex	235	(12)
J.L. Raymond
S.G. Lisberger
On the nature of gain changes of the optokinetic reflex	247	(10)
M.A. Frens
A.L. Mathoera
J. Van der Steen
Use-dependent changes in synaptic strength at the Purkinje cell to deep nuclear synapse	257	(18)
C.D. Aizenman
E.J. Huang
P.B. Manis
D.J. Linden
Time window control: a model for cerebellar function based on synchronization, reverberation and time slicing	275	(24)
W.M. Kistler
J.L. van Hemmen
C.I. De Zeeuw
Electrophysiological behavior of Purkinje cells and motor coordination in calretinin knock-out mice	299	(10)
G. Cheron
S. Schurmans
A. Lohof
P. D'Alcantara
M. Meyer
J.-P. Draye
M. Parmentier
S.N. Schiffmann
Contralateral cerebellar involvement in conditioned eyeblink responses	309	(8)
M. Ivarsson
P. Svensson
G. Hesslow
Involvement of the cerebellum in a new temporal property of the conditioned eyeblink response	317	(8)
P. Svensson
M. Ivarsson
G. Hesslow
Subject Index	325