Cerebral Signal Transduction

by Reith, Maarten E. A.

• ISBN13: 9780896036086
• ISBN10: 0896036081
• Format: Hardcover
• Copyright: 2000-03-01
• Publisher: Humana Pr Inc

Summary

A team of leading experts comprehensively review and synthesize the most recent advances in our understanding of the role of cerebral signaling in neuronal and cerebral function. The authors emphasize the functional role of the various signaling pathways in memory, apoptosis and degeneration, depression, and drug dependence in both health and diseased states. By taking full advantage of the newfound ability to selectively remove, reduce, or enhance specific components of the signaling pathways, the investigators writing here illuminate the varied signaling cascades, their crosstalk, and the many possibilities for changes in gene expression underlying long-term changes in brain function. Cutting-edge and comprehensive, Cerebral Signal Transduction: From First to Fourth Messengers advances our understanding of the mechanistic underpinnings of complex behavioral processes and clinically relevant brain diseases. A major contribution to the development of the novel pharmacotherapeutics targeting downstream events in the cascade of second, third, and fourth messengers, it will serve experimental and clinical neuroscientists as the best and most complete guide to neuronal signaling.

Table of Contents

Preface	v
Contributors	xi
Part I. Introduction
From First to Fourth Messengers in the Brain: An Overview	3	(24)
Maarten E.A. Reith
Part II. Memory
Cellular and Molecular Mechanisms of Learning and Memory	27	(46)
Matthew Lattal
Ted Abel
Signal Transduction Pathways in Well-Defined models of Learning and Memory: Drosophila and Honeybee	73	(32)
Uli Muller
Protein Kinase C Signaling in Learning and Memory	105	(24)
Eddy A. Van der Zee
Bas R. K. Douma
John F. Disterhoft
Paul G. M. Luiten
Part III. Neurodegeneration and Apoptosis
Neurotransmitter Receptor--G-Protein-Mediated Signal Transduction in Alzheimer's Disease	129	(22)
Richard F. Cowburn
The NO Signaling Pathway in the Brain: Neural Injury, Neurological Disorders, and Aggression	151	(24)
Masayuki Sasaki
Valina L. Dawson
Ted M. Dawson
Cellular Signaling Pathways in Neuronal Apoptosis: Role in Neurodegeneration and Alzheimer's Disease	175	(32)
Carl W. Cotman
Haoyu Qian
Aileen J. Anderson
The Role of Second Messengers in Neurodegeneration	207	(16)
Aase Frandsen
Jette Bisgaard Jensen
Arne Schousboe
Part IV. Depression
Molecular and Cellular Determinants of Stress and Antidepressant Treatment	223	(26)
Ronald S. Duman
Long-Term Bidirectional Hormonal and Neuroplastic Responses to Stress: Implications for the Treatment of Depression	249	(34)
Robert M. Post
Susan R. B. Weiss
Li-Xin Zhang
M. Guoqiang Xing
Signal Transduction Abnormalities in Bipolar Affective Disorder	283	(30)
Peter P. Li
Stavroula Andreopoulos
Jerry J. Warsh
Part V. Drug Dependence
Messengers in Opioid Dependence: Gene Disruption Studies	313	(28)
Rafael Maldonado
Olga Valverde
The 5-HT1B Knockout Mouse: An Animal Model of Vulnerability to Drugs of Abuse	341	(34)
Kimberly Scearce-Levie
Rene Hen
Regulation of Dopamine Transporter by Phosphorylation and Impact on Cocaine Action	375	(26)
Roxanne A. Vaughan
Dopamine Transporter mRNA in Human Brain: Distribution and Regulatory Effects in Autopsy Studies of Cocaine Abusers	401	(18)
Deborah C. Mash
Li Chen Kramer
David Segal
Sari Izenwasser
Index	419