Challenges in Inflammatory Bowel Disease

by Jewell, Derek P.; Mortensen, Neil J.; Steinhart, A. Hillary; Pemberton, John A.; Warren, Bryan F.

• ISBN13: 9781405122344
• ISBN10: 140512234X
• Edition: 2nd
• Format: Hardcover
• Copyright: 2006-07-05
• Publisher: Wiley-Blackwell

Summary

Reviews focused topics - both clinical and basic science - in the fast-moving area of IBD, providing emphasis on the current challenges faced in the successful management of the diseaseTurn to Challenges in Inflammatory Bowel Disease (IBD) when you need an expert opinion on the new, unusual or controversial areas of IBD and not just the tried and tested information. Current and concise reviews of the latest scientific discoveries are translated into cutting-edge clinical guidance to address those challenging cases faced by every medical team caring for patients with IBD.Refer to this book to answer burning questions, to read an in depth review of the controversial topics and to provide a clear explanation of issues.Each chapter gives a balanced overview of the topics written by experts in the field and covers all aspects from investigation into the scientific basis of the disease through to its management and prognosis.

Author Biography

Professor Derek P. Jewell, Gastroenterology Unit, Radcliffe Infirmary, Oxford, UK

Professor Neil J. Mortensen, John Radcliffe Hospital, Oxford, UK

Professor A. Hillary Steinhart, Mount Sinai Hospital, Toronto, Canada

Professor John H. Pemberton, Mayo Clinic, Rochester, US

Dr Bryan F. Warren, John Radcliffe Hospital, Oxford, UK

Table of Contents

List of Contributors and Editors	vii
Preface	xi
I. Clues to aetiology and pathogenesis	1	(64)
Global changes in incidence	3	(11)
Richard F. A. Logan
Emma L. Armitage
The role of genetics in inflammatory bowel disease	14	(19)
John B. Beckly
Tariq Ahmad
Derek P. Jewell
Microbial sensing in the intestine by pattern recognition receptors	33	(11)
Robin G. Lorenz
Charles O. Elson
The role of bacteria	44	(13)
Robert Penner
Karen Madsen
The appendix -- how might it influence susceptibility to ulcerative colitis: the legend of Qebehsenuef	57	(8)
Kenneth Croitoru
II. Diagnosis and assessment	65	(52)
What are the controversies in histopathological diagnosis?	67	(18)
Bryan F. Warren
Neil A. Shepherd
The challenges of using capsule endoscopy in the diagnosis and management of inflammatory bowel disease	85	(20)
Gary C. Chen
Simon K. Lo
Cross-sectional imaging of inflammatory bowel disease	105	(12)
Stuart Taylor
Steve Halligan
III. Management of ulcerative colitis	117	(62)
Mesalazine for maintenance therapy in ulcerative colitis - how much, how long?	119	(5)
Miles P. Sparrow
Wee-Chian Lim
Stephen B. Hanauer
Refractory distal colitis	124	(20)
Simon Travis
Pharmabiotics and inflammatory bowel disease -- on the verge of evidence-based medicine	144	(10)
Fergus Shanahan
Jude Ryan
Shomik Sibartie
Current controversies in the surgical management of ulcerative colitis	154	(13)
R. John Nicholls
Mark J. Cheetham
What are the causes and treatment of ileoanal pouch dysfunction?	167	(12)
Alan F. Horgan
William J. Sandborn
John H. Pemberton
IV. Management of Crohn's disease	179	(148)
Is mesalazine useful in Crohn's disease?	181	(13)
A. Hillary Steinhart
Steroids or nutrition?	194	(12)
Miquel A. Gassull
Do antibiotics have a role in Crohn's disease?	206	(7)
Severine Vermeire
Paul Rutgeerts
The optimal use of infliximab in Crohn's disease	213	(8)
Geert D'Haens
Designer drugs: from bench to bedside	221	(11)
Stephan R. Targan
Loren C. Karp
Current controversies in the surgical management of Crohn's disease	232	(14)
W.M. Chambers
I. Lindsey
N.J. Mortensen
Perianal Crohn's disease	246	(20)
Carl J. Brown
Robin S. Mcleod
What is dysplasia?	266	(15)
Karel Geboes
Colonoscopic surveillance -- if and when?	281	(12)
Urban Sjoqvist
Robert Lofberg
Cancer: new colonoscopic techniques	293	(10)
Ralf Kiesslich
Markus F. Neurath
Molecular markers -- a realistic hope?	303	(9)
Jacintha N. O'Sullivan
Teresa A. Brentnall
Adenomas versus dysplasia associated lesion or mass -- recognition and management?	312	(15)
Maha Guindi
Robert H. Riddell
V. Special management problems	327	(50)
Growth impairment in children	329	(11)
Thomas D. Walters
Anne M. Griffiths
Osteopenia	340	(20)
Subrata Ghosh
Pregnancy	360	(9)
Philippe Marteau
Can prognosis of ulcerative colitis be predicted?	369	(8)
Robert Hilsden
Lloyd Sutherland
Index	377