Characterization of Pharmaceutical Nano- and Microsystems

by Peltonen, Leena; Douroumis, Dennis; Fahr, Alfred; Siepmann, Jü; rgen; Snowden, Martin J.; Torchilin, Vladimir

• ISBN13: 9781119414049
• ISBN10: 1119414040
• Edition: 1st
• Format: Hardcover
• Copyright: 2020-12-21
• Publisher: Wiley

Summary

Learn about the analytical tools used to characterize particulate drug delivery systems with this comprehensive overview

Edited by a leading expert in the field, Characterization of Pharmaceutical Nano- and Microsystems provides a complete description of the analytical techniques used to characterize particulate drug systems on the micro- and nanoscale.

The book offers readers a full understanding of the basic physicochemical characteristics, material properties and differences between micro- and nanosystems. It explains how and why greater experience and more reliable measurement techniques are required as particle size shrinks, and the measured phenomena grow weaker.

Characterization of Pharmaceutical Nano- and Microsystems deals with a wide variety of topics relevant to chemical and solid-state analysis of drug delivery systems, including drug release, permeation, cell interaction, and safety. It is a complete resource for those interested in the development and manufacture of new medicines, the drug development process, and the translation of those drugs into life-enriching and lifesaving medicines.

Characterization of Pharmaceutical Nano- and Microsystems covers all of the following topics:

• An introduction to the analytical tools applied to determine particle size, morphology, and shape
• Common chemical approaches to drug system characterization
• A description of solid-state characterization of drug systems
• Drug release and permeation studies
• Toxicity and safety issues
• The interaction of drug particles with cells

Perfect for pharmaceutical chemists and engineers, as well as all other industry professionals and researchers who deal with drug delivery systems on a regular basis, Characterization of Pharmaceutical Nano- and Microsystems also belongs on bookshelves of interested students and faculty who interact with this topic.

Author Biography

Leena Peltonen is Adjunct Professor in the Division of Pharmaceutical Chemistry and Technology at the University of Helsinki, Finland. She holds two master’s degrees, as well as a PhD in Pharmacy that she obtained in 2001. 

Dionysios (Dennis) Douroumis is Professor in Pharmaceutical Technology and Process Engineering at the University of Greenwich in the United Kingdom. He is also the Director of the Centre for Innovation in Process Engineering and Research.  

Alfred Fahr is Professor Emeritus at the Institute of Pharmaceutical Technology at Friedrich-Schiller-Universität Jena in Germany.   

Jürgen Siepmann is Professor of Pharmaceutical Technology at the University of Lille in France. He is the President of the International Society of Drug Delivery Sciences and Technology.  

Martin Snowden is Professor in Colloid and Polymer Science and Pro Vice-Chancellor for the Faculty of Engineering and Science at the University of Greenwich in the United Kingdom. He was the chair of the Academy of Pharmaceutical Science of the United Kingdom from 2010 to 2012.    

Vladimir Torchilin is Professor of Pharmaceutical Sciences and the Director of the Center for Pharmaceutical Biotechnology and Nanomedicine at Northeastern University in the United States. 

Table of Contents

Part I - Particle size, size distribution, shape and morphology

1. Particle sizing of micro- and nanoparticles

2. Microscopy characterisation of micro- and nanosystems

3. Particle shape - important factor in drug delivery    

4. Particle size, shape and porosity effect on bioavailability of small particles

 

Part II - Chemical analysis and solid state characterization

5. HPLC analysis for chemical stability and degradation analysis of drugs    

6. Surface properties tailoring and particle characterization

7. Spectroscopic techniques in physical state analysis

8. Thermal methods for physical state characterization

9. Potential of X-ray analysis for nano-and microparticle studies

10. Miniaturized chemical drug analysis on a single microfluidic chip

 

Part III - Drug release and permeation studies

11. Dissolution studies from single particle systems    

12. Dissolution and permeation testing of nano- and microparticulate systems    

13. Solubility of nanoparticles, importance of saturation solubility and its maintenance in nanoparticulate systems

14. Biorelevant dissolution testing of nanosystems

 

Part IV - Cell interactions, toxicity and safety issues

15. Biophysics and biomechanics of the interactions between nanoparticles and cell membrane lipids and the role of critical interaction in cellular uptake and intracellular trafficking of nanoparticles and their biodistribution in vivo

16. Cytotoxicity testing of nano – and microparticles

17. Nanotoxicity and nanosafety issues

 

Part V – Data Analysis

18. Data analysis, principal component analysis