Chemical Process Research The Art of Practical Organic Synthesis

by Abdel-Magid, Ahmed F.; Ragan, John A.

• ISBN13: 9780841238244
• ISBN10: 0841238243
• Format: Hardcover
• Copyright: 2003-12-25
• Publisher: American Chemical Society

Summary

This book shows the diversity of structural problems and synthesis solution as well as the practical aspects and methodologies required for large-scale syntheses. The eleven chapters focus on chemical process research in the pharmaceutical industry.

Table of Contents

Preface	ix
Reflections on Process Research	1	(22)
Edward J. J. Grabowski
Synthesis of Cell Adhesion Inhibitors via Crystallization-Driven Dynamic Transformations	23	(16)
Magnus Eriksson
Vittorio Farina
Suresh Kapadia
Elio Napolitano
Nathan K. Yee
Synthetic, Structural, and Mechanistic Issues in the Development of a Subtype Selective GABA Partial Agonist Hypnotic Agent	39	(20)
John A. Ragan
Jerry A. Murry
Michael J. Castaldi
Alyson K. Conrad
Paul D. Hill
Brian P. Jones
Narasimhan Kasthurikrishnan
Bryan Li
Teresa W. Makowski
Ruth McDermott
Barb J. Sitter
Timothy D. White
Gregory R. Young
Process Research and Initial Scale-Up of ABT-839: A Farnesyltransferase Inhibitor	59	(12)
Todd S. McDermott
Ramiya Premchandron
Anne E. Bailey
Lakshmi Bhagavatula
Howard E. Morton
Synthetic Approaches to the Retinoids	71	(16)
Margaret M. Faul
Design of Experiments in Pharmaceutical Process Research and Development	87	(24)
John E. Mills
Process Development for the MMP Inhibitor AG3433	111	(14)
Jayaram K. Srirangam
Ming Guo
Shu Yu
Alan W. Grubbs
James Saenz
Steven L. Bender
Judith G. Deal
Kuenshan S. Lee
Jason Liou
Robert Szendroi
James Faust
Kim Albizati
Dihydro-7-benzofurancarboxylic Acid: An Intermediate in the Synthesis of the Enterokinetic Agent R108512	125	(16)
Bert Willemsens
Alex Copmans
Dirk Beerens
Stef Leurs
Dirk de Smaele
Max Rey
Silke Farkas
Process Research Leading to an Enantioselective Synthesis of a 5-Lipoxygenase Inhibitor for Asthma	141	(20)
David B. Damon
Michael Butters
Robert W. Dugger
Peter Dunn
Sally Gut
Brian P. Jones
Thomas G. LaCour
C. William Murtiashaw
Harry A. Watson Jr.
James Weeks
Timothy D. White
A Practical Synthesis of Tetrasubstituted Imidazole p38 MAP Kinase Inhibitors: A New Method for the Synthesis of α-Amidoketones	161	(20)
Jerry A. Murry
Doug Frantz
Lisa Frey
Arash Soheili
Karen Marcantonio
Richard Tillyer
Edward J. J. Grabowski
Paul J. Reider
Solution Phase Synthesis of the Pulmonary Surfactant KL4: A 21 Amino Acid Synthetic Protein	181	(20)
Ahmed F. Abdel-Magid
Mary Ellen Bos
Urs Eggmann
Cynthia A. Maryanoff
Lorraine Scott
Adrian Thaler
Frank J. Villani
Indexes
Author Index	201	(2)
Subject Index	203