Chemistry for Pharmacy Students : General, Organic and Natural Product Chemistry

by Sarker, Satyajit; Nahar, Lutfun

• ISBN13: 9780470017807
• ISBN10: 0470017805
• Edition: 1st
• Format: Hardcover
• Copyright: 2007-08-13
• Publisher: Wiley-Interscience

Summary

"This book has succeeded in covering the basic chemistry essentials required by the pharmaceutical science student... the undergraduate reader, be they chemist, biologist or pharmacist will find this an interesting and valuable read." -Journal of Chemical Biology, May 2009Chemistry for Pharmacy Students is a student-friendly introduction to the key areas of chemistry required by all pharmacy and pharmaceutical science students. The book provides a comprehensive overview of the various areas of general, organic and natural products chemistry (in relation to drug molecules).Clearly structured to enhance student understanding, the book is divided into six clear sections. The book opens with an overview of general aspects of chemistry and their importance to modern life, with particular emphasis on medicinal applications. The text then moves on to a discussion of the concepts of atomic structure and bonding and the fundamentals of stereochemistry and their significance to pharmacy- in relation to drug action and toxicity. Various aspects of aliphatic, aromatic and heterocyclic chemistry and their pharmaceutical importance are then covered with final chapters looking at organic reactions and their applications to drug discovery and development and natural products chemistry.accessible introduction to the key areas of chemistry required for all pharmacy degree courses student-friendly and written at a level suitable for non-chemistry students includes learning objectives at the beginning of each chapter focuses on the physical properties and actions of drug molecules

Author Biography

 

Table of Contents

Preface	p. ix
Introduction	p. 1
Role of chemistry in modern Life	p. 1
Physical properties of drug molecules	p. 3
Atomic structure and bonding	p. 17
Atoms, elements and compounds	p. 17
Atomic structure: orbitals and electronic configurations	p. 18
Chemical bonding theories: formation of chemical bonds	p. 21
Electronegativity and chemical bonding	p. 27
Bond polarity and intermolecular forces	p. 28
Significance of chemical bonding in drug-receptor interactions	p. 31
Stereochemistry	p. 35
Stereochemistry: definition	p. 36
Isomerism	p. 36
Significance of stereoisomerism in determining drug action and toxicity	p. 53
Synthesis of chiral molecules	p. 55
Separation of stereoisomers: resolution of racemic mixtures	p. 56
Compounds with stereocentres other than carbon	p. 57
Chiral compounds that do not have a tetrahedral atom with four different groups	p. 57
Organic functional groups	p. 59
Organic functional groups: definition and structural features	p. 60
Hydrocarbons	p. 61
Alkanes, cycloalkanes and their derivatives	p. 61
Alkenes and their derivatives	p. 103
Alkynes and their derivatives	p. 108
Aromatic compounds and their derivatives	p. 112
Heterocyclic compounds and their derivatives	p. 143
Nucleic acids	p. 170
Amino acids and peptides	p. 179
Importance of functional groups in determining drug actions and toxicity	p. 184
Importance of functional groups in determining stability of drugs	p. 188
Organic reactions	p. 191
Types of organic reaction	p. 191
Radical reactions: free radical chain reactions	p. 192
Addition reactions	p. 197
Elimination reactions: 1,2-elimination or [beta]-elimination	p. 223
Substitution reactions	p. 232
Hydrolysis	p. 260
Oxidation-reduction reactions	p. 264
Pericyclic reactions	p. 278
Natural product chemistry	p. 283
Introduction to natural product drug discovery process	p. 283
Alkaloids	p. 288
Carbohydrates	p. 303
Glycosides	p. 319
Terpenoids	p. 331
Steroids	p. 352
Phenolics	p. 359
Index	p. 371
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