What is included with this book?
Preface | p. ix |
Introduction | p. 1 |
Role of chemistry in modern Life | p. 1 |
Physical properties of drug molecules | p. 3 |
Atomic structure and bonding | p. 17 |
Atoms, elements and compounds | p. 17 |
Atomic structure: orbitals and electronic configurations | p. 18 |
Chemical bonding theories: formation of chemical bonds | p. 21 |
Electronegativity and chemical bonding | p. 27 |
Bond polarity and intermolecular forces | p. 28 |
Significance of chemical bonding in drug-receptor interactions | p. 31 |
Stereochemistry | p. 35 |
Stereochemistry: definition | p. 36 |
Isomerism | p. 36 |
Significance of stereoisomerism in determining drug action and toxicity | p. 53 |
Synthesis of chiral molecules | p. 55 |
Separation of stereoisomers: resolution of racemic mixtures | p. 56 |
Compounds with stereocentres other than carbon | p. 57 |
Chiral compounds that do not have a tetrahedral atom with four different groups | p. 57 |
Organic functional groups | p. 59 |
Organic functional groups: definition and structural features | p. 60 |
Hydrocarbons | p. 61 |
Alkanes, cycloalkanes and their derivatives | p. 61 |
Alkenes and their derivatives | p. 103 |
Alkynes and their derivatives | p. 108 |
Aromatic compounds and their derivatives | p. 112 |
Heterocyclic compounds and their derivatives | p. 143 |
Nucleic acids | p. 170 |
Amino acids and peptides | p. 179 |
Importance of functional groups in determining drug actions and toxicity | p. 184 |
Importance of functional groups in determining stability of drugs | p. 188 |
Organic reactions | p. 191 |
Types of organic reaction | p. 191 |
Radical reactions: free radical chain reactions | p. 192 |
Addition reactions | p. 197 |
Elimination reactions: 1,2-elimination or [beta]-elimination | p. 223 |
Substitution reactions | p. 232 |
Hydrolysis | p. 260 |
Oxidation-reduction reactions | p. 264 |
Pericyclic reactions | p. 278 |
Natural product chemistry | p. 283 |
Introduction to natural product drug discovery process | p. 283 |
Alkaloids | p. 288 |
Carbohydrates | p. 303 |
Glycosides | p. 319 |
Terpenoids | p. 331 |
Steroids | p. 352 |
Phenolics | p. 359 |
Index | p. 371 |
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