Chemometric Methods in Capillary Electrophoresis

by Hanrahan, Grady; Gomez, Frank A.

• ISBN13: 9780470393291
• ISBN10: 0470393297
• Edition: 1st
• Format: Hardcover
• Copyright: 2009-11-16
• Publisher: Wiley

Summary

Use chemometric techniques to develop optimum separation conditions for capillary electrophoresesFor all its advantages, capillary electrophoresis (CE) also carries significant disadvantages for the researcher. Offering a unique blend of information from authors active in a variety of developments of chemometrics in CE, Chemometric Methods in Capillary Electrophoresis presents modern chemometric methods as an alternative to help alleviate the problems commonly encountered during routine analysis and method development.Focusing on current chemometric methods utilized in CE endeavours by research-active experts in the field, the book begins with a thorough introduction to CE and chemometric-related concepts and the need for modern chemometric methods in CE.Part 1 discusses differing types of screening designs and response surface methodology)in an)application based formatPart 2 includes vital discussion on various exploratory data analysis, prediction, and classification techniques utilized in CE-related studiesPart 3 provides practical information on modelling quantitative structure relationshipsPart 4 explores transformation techniques, in particular fundamental studies and applications of cross-correlation and Hadamard Transform ElectrophoresisShowing how chemometric methods are applied in a wide array of applications including biological, medical, pharmaceutical, food, forensic, and environmental science, Chemometric Methods in Capillary Electrophoresis is not only highly significant to capillary electrophoresis-based endeavours, but instructive for investigators active in other areas of separation science who could benefit from its informative content.

Author Biography

Grady Hanrahan, PhD, received his doctorate in environmental analytical chemistry from the University of Plymouth, England. Dr. Hanrahan is currently the John Stauffer Endowed Professor of Analytical Chemistry at California Lutheran University with research interests in the use of modern chemometric methods in the design and development of environmental and bioanalytical instrumentation. He is also exploring the use of neural and evolutionary computational techniques for solving complex chemical problems. Frank a. Gomez, PhD, received his BS in chemistry from California State University, Los Angeles (CSULA), and his PhD in chemistry from UCLA, where he was a NIH Predoctoral Fellow. From 1991-1994, he was a Damon Runyon-Walter Winchell Cancer Research Fund Postdoctoral Fellow in the department of chemistry at Harvard University. He is a professor of chemistry at CSULA and is a visiting associate at Caltech in the Applied Physics department.

Table of Contents

Preface	p. ix
Acknowledgments	p. xi
Editor Biographies	p. xii
Contributors	p. xv
Key acronyms	p. xix
Experimental Design And Optimization Considerations	p. 1
Introduction	p. 3
Experimental Design In Method Optimization And Robustness Testing	p. 11
Chemometrical Experimental Design-based Optimization Studies In Capillary Electrophoresis Applications	p. 75
Application Of Chemometric Methods In Drug Purity Determination By Capillary Electrophoresis	p. 93
Optimization Of Micellar Electrokinetic Chromatography Separation Conditions By Chemometric Methods	p. 113
Chemometric Methods For The Optimization Of Ce And Ce-Ms In Pharmaceutical, Environmental, And Food Analysis	p. 133
Optimization Of The Separation Of Amino Acids By Capillary Electrophoresis Using Artificial Neural Networks	p. 169
Exploratory Data Analysis, Prediction, And Classification	p. 181
Development Of Capillary Electrophoresis Fingerprints And Multivariate Statistics For The Differentiation Of Opium And Poppy Straw Samples	p. 183
Multivariate Curve Resolution Based On Alternating Least Squares In Capillary Electrophoresis	p. 199
Application Of Chemometrics In Capillary Electrophoresis Analysis Of Herbal Medicines	p. 227
Clinical Pattern Recognition Analysis Applying Artificial Neural Networks Based On Principal Component Analysis Input Selection	p. 243
Chemometric Methods Applied To Genetic Analyses By Capillary Electrophoresis And Electrophoresis Microchip Technologies	p. 261
Exploratory Data Analysis And Classification Of Capillary Electrophoretic Data	p. 291
Quantitative Structure Relationships	p. 323
Chemometrical Modeling Of Electrophoretic Mobilities In Capillary Electrophoresis	p. 325
Assessment Of Solute-Micelle Interactions In Electrokinetic Chromatography Using Quantitative Structure-Retention Relationships	p. 345
Chemometrical Analysis Of Cheese Proteolysis Profiles By Capillary Electrophoresis: Prediction Of Ripening Times	p. 367
Transformation Techniques	p. 389
Transformation Techniques For Capillary And Microchip Electrophoresis	p. 391
Index	p. 407
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