We're sorry, but eCampus.com doesn't work properly without JavaScript.
Either your device does not support JavaScript or you do not have JavaScript enabled.
How to enable JavaScript in your browser.
Need help? Call 1-855-252-4222
An integrated view of chiral drugsfrom concept and synthesisto pharmaceutical properties
Chirality greatly influences a drug's biological and pharmacological properties. In an effort to achieve more predictable results from chiral drugs, the Food and Drug Administration now requires that these medicines be as pure as possible, which places great demands on drug synthesis, purification, analysis, and testing. To assist researchers in acquiring the essential knowledge to meet these rigid guidelines, Chiral Drugs focuses on three vital chiral technologiesasymmetric synthesis, biocatalytic process, and chiral resolutionto offer details on the basic concepts, key developments, and recent trends in chiral drug discovery, along with:
The history of chiral drugs development and industrial applications of chiral technologies
A section listing twenty-five approved or advanced-trial chiral drugs that lists each drug name, chemical name and properties, a representative synthetic pathway, pharmacological characterizations, and references
An interdisciplinary approach combining synthetic organic chemistry, medicinal chemistry, and pharmacology
Nearly two-thirds of the drugs on today's market are chiral drugs. Reducing and eliminating their negative characteristics is an ongoing and serious challenge for the pharmaceutical industry. With its well-balanced approach to covering each important aspect of chirality, Chiral Drugs champions important strategies for tipping the medical scale in a positive direction for the production of more effectiveand saferdrugs.
QI-DONG YOU, PHD, is the Dean and a professor of the School of Pharmacy at China Pharmaceutical University. He is an Associate Editor of Progress in Pharmaceutical Sciences and serves on the Editorial Board of the International Journal of Medicinal Chemistry and Acta Pharmaceutica Sinica. Dr. You is a coauthor of over eighty publications, and an inventor or co-inventor of over twenty patent applications and patents.
JIE-FEI CHENG, PHD, is the Director of Otsuka Shanghai Research Institute, a fully owned subsidiary of Otsuka Pharmaceutical Co., Ltd Japan. Formerly an associate professor at Shanghai Institute of Organic Chemistry, he has worked for over fifteen years in the pharmaceutical and biotech industries in the United States. Dr. Cheng is a coauthor of over fifty peer-reviewed publications, and an inventor or coinventor of over twenty patent applications and patents.
CONTRIBUTORS ix
INTRODUCTION 1
1 OVERVIEW OF CHIRALITY AND CHIRAL DRUGS 3Guo-Qiang Lin, Jian-Ge Zhang, and Jie-Fei Cheng
2 CHIRAL DRUGS THROUGH ASYMMETRIC SYNTHESIS 29Guo-Qiang Lin and Xing-Wen Sun
3 CHIRAL DRUGS VIA BIOCATALYTICAL APPROACHES 77Jianqiang Wang and Wenya Lu
4 RESOLUTION OF CHIRAL DRUGS 137Qi-Dong You
5 FLUORINE-CONTAINING CHIRAL DRUGS 195Xiao-Long Qiu, Xuyi Yue, and Feng-Ling Qing
6 INDUSTRIAL APPLICATION OF CHIRAL TECHNOLOGIES 253Hui-Yin (Harry) Li, Rui Liu, Carl Behrens, and Chao-Ying Ni
7 STRUCTURAL BASIS AND COMPUTATIONAL MODELING OF CHIRAL DRUGS 297Deping Wang and Eric Hu
8 PHARMACOLOGY OF CHIRAL DRUGS 323Yongge Liu and Xiao-Hui Gu
9 PHARMACOKINETICS OF CHIRAL DRUGS 347Hanqing Dong, Xiaochuan Guo and Zengbiao Li
10 TOXICOLOGY OF CHIRAL DRUGS 381Guang Yang and Hai-Zhi Bu
11 REPRESENTATIVE CHIRAL DRUGS 401Jiangqin Sun, Dingguo Liu, and Zhimin Wang
INDEX 449
The New copy of this book will include any supplemental materials advertised. Please check the title of the book to determine if it should include any access cards, study guides, lab manuals, CDs, etc.
The Used, Rental and eBook copies of this book are not guaranteed to include any supplemental materials. Typically, only the book itself is included. This is true even if the title states it includes any access cards, study guides, lab manuals, CDs, etc.