Chiral Sulfur Ligands

by Pellissier, Helene

• ISBN13: 9781847559241
• ISBN10: 1847559247
• Format: Hardcover
• Copyright: 2009-11-01
• Publisher: Royal Society of Chemistry

Summary

The preparation of chiral compounds is an important area of contemporary synthetic organic chemistry. Most natural products are chiral and their physiological or pharmacological properties depend upon their recognition by chiral receptors. The use of chiral drugs in the enantiopure form is now a standard requirement and the development of new synthetic methods to obtain enantiopure compounds has become a key objective for pharmaceutical companies.

Table of Contents

General Introduction	p. 1
Allylic Substitution	p. 7
Introduction	p. 7
S/S Ligands	p. 10
S/P Ligands	p. 15
S/N Ligands	p. 26
S/C and S/O Ligands	p. 40
Sulfur-Containing P/N, P/O, N/N, N/O and P/P Ligands	p. 41
Sulfur-Containing Ferrocenyl Ligands	p. 53
Conclusions	p. 64
References	p. 65
Conjugate Addition	p. 74
Introduction	p. 74
Copper Catalysts	p. 75
Other Metal Catalysts	p. 96
Conclusions	p. 101
References	p. 101
Addition of Organometallic Reagents to Aldehydes	p. 105
Introduction	p. 105
Addition of Organozinc Reagents to Aldehydes	p. 106
Addition of Dialkylzinc Reagents to Aldehydes	p. 106
S/N Ligands	p. 106
S/N/O Ligands	p. 119
S/O Ligands	p. 138
Sulfur-Containing Ferrocenyl Ligands	p. 141
Addition of Aryl-, Alkenyl-and Alkynylzinc Reagents to Aldehydes	p. 142
Addition of Organometallic Reagents other than Organozinc Reagents	p. 147
Conclusions	p. 150
References	p. 150
Addition of Organozinc Reagents to Ketones	p. 156
References	p. 181
	p. Diels-Aider
References	p. 205
Cyclopropanation	p. 208
Introduction	p. 208
Transition-Meial-Catalysed Decomposition of Diazoalkanes	p. 209
Sulfide Ligands	p. 210
Thiophene Ligands	p. 210
Sulfoxide Ligands	p. 214
Sulfonamide Ligands	p. 214
Simmons-Smith Cyclopropanation	p. 222
Conclusions	p. 228
References	p. 229
Heck-Type Reactions	p. 233
References	p. 241
Hydrogenation	p. 243
Introduction	p. 243
Hydrogenation of Olefins	p. 243
Hydrogenation of Ketones	p. 259
Conclusions	p. 267
References	p. 268
Hydrogen Transfer	p. 270
References	p. 290
Miscellaneous Reactions	p. 293
Introduction	p. 293
Hydroformyiation	p. 293
1,3-Dipolar Cycloaddition	p. 296
[2+2] Cycloaddition	p. 304
Carbonyl Ene Reaction	p. 306
Addition of Diethylzinc to Imines	p. 307
Allylstannation of Ketones	p. 310
Allylsilylation of Carbonyl Compounds	p. 311
Aldol-Type Reaction	p. 313
Mannich-Type Reaction	p. 320
Claisen Rearrangement	p. 321
Epoxidation	p. 324
Silyfcyanation	p. 327
Hydrosilylation	p. 329
Borane Reduction	p. 336
Pauson-Khand Reaction	p. 344
Radical C-C Bond-Forming Reaction	p. 348
Ring Opening of Mesoheterobicyclic Alkenes	p. 348
Bisalkoxycarbonyiation of Olefins	p. 350
C-H Insertion	p. 351
Hydroamination and Amination	p. 356
Reissert Reaction	p. 359
Aziridination	p. 360
Grignard Crosscoupling	p. 362
Conclusions	p. 367
General Conclusion	p. 368
References	p. 370
Subject Index	p. 380
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