Chromatin and Disease

by Kundu, Tapas K.; Das Gupta, Dipak

• ISBN13: 9781402054655
• ISBN10: 1402054653
• Edition: 1st
• Format: Hardcover
• Copyright: 2007-04-13
• Publisher: Springer Verlag

Summary

The packaging of genomic DNA together with core histones, linker histones, and other functional proteins into chromatin play key roles in nuclear processes such as transcription, replication, repair and recombination. Research in the last two decades has unveiled the fact that many diseases involve an aberration of these processes at the chromatin level. Similarly, it is becoming clear that different processes such as chromatin assembly, remodeling of chromatin structure coupled to covalent modification of histone and non-histone proteins, chromatin modifying enzymes and last but not the least, important DNA-templated phenomena are the potential drug targets for diseases such as different types of cancer, neurodegenrative diseases, AIDS etc. While, the earliest form of chemotherapy employed chromosomal DNA cleavage and modification, the study of epigenetic functions and therapy has recently emerged as a frontline research activity. At this juncture we felt the necessity to make an overview of the current research activities in the above areas. It is obvious that this collection starts with our current knowledge of chromatin structure. This Work is the first endeavor to present different aspects encompassing the above theme. This volume will give a state-of-the'art knowledge to undergraduate students, as well as the research community.

Table of Contents

Preface	p. xi
Chromatin Structure, Dynamics and Disease	p. 1
Structural Organization of Dynamic Chromatin	p. 3
ATP-Dependent Chromatin Remodelling: Action and Reaction	p. 29
Regulation of Chromatin Structure and Chromatin-Dependent Transcription by Poly (ADP-Ribose) Polymerase-1: Possible targets for drug-based therapies	p. 45
Histone Variant Nucleosomes: Structure, function and implication in disease	p. 71
Histone Variants and Complexes Involved in Their Exchange	p. 91
Histone Chaperones in Chromatin Dynamics: Implications in disease manifestation	p. 111
Functions of the Histone Chaperone Nucleolin in Diseases	p. 125
Chromatin as a Target for the DNA-Binding Anticancer Drugs	p. 145
Nonhistone Proteins, Sites for Epigenetic Marks: Link to Disease	p. 191
Reversible Acetylation of Non Histone Proteins: Role in cellular function and disease	p. 193
MARs and MARBPs: Key modulators of gene regulation and disease manifestation	p. 213
Epigenetic Modifications of Chromatin: Implication in Disease and Therapeutics	p. 231
Aberrant Forms of Histone Acetyltransferases in Human Disease	p. 233
Chromatin Acetylation Status in the Manifestation of Neurodegenerative Diseases: HDAC inhibitors as therapeutic tools	p. 263
Functions of MYST Family Histone Acetyltransferases and Their Link to Disease	p. 295
Role of Histone Phosphorylation in Chromatin Dynamics and Its Implications for Diseases	p. 319
Regulation and Function of H3K9 Methylation	p. 337
Histone Acetylation and Methylation: Combinatorial players for transcriptional regulation	p. 351
Chromatin-Associated Regulation of HIV-1 Transcription: Implications for the development of therapeutic strategies	p. 371
Small Molecule Modulators in Epigenetics: Implications in gene expression and therapeutics	p. 397
Index	p. 429
Colour Plates	p. 435
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