Chronic Graft Versus Host Disease: Interdisciplinary Management

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  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2009-04-20
  • Publisher: Cambridge University Press
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Supplemental Materials

What is included with this book?


Chronic graft versus host disease (GVHD) is the most common complication of allogenic bone marrow transplantation. Because of the protracted clinical course of chronic GVHD, transplant centers and hematology/oncology offices are inadequately equipped to manage these immuno-incompetent patients with a multi-system disorder. Practitioners need to be able to recognize and effectively manage chronic GVHD as a late effect of more than half of allogenic transplantations. The text is oriented for the clinician, with chapters covering staging, organ site and system-specific manifestations, treatment options, and supportive care. Drs. Georgia B. Vogelsang and Steven Z. Pavletic have been pioneers in the recognition of the multi-organ complexity of this disease and have gathered the input of a variety of subspecialist physicians for this book. This book fills the gap in practical literature on chronic GVHD, providing a comprehensive, up-to-date, and clinically relevant resource for anyone who deals with cancer patients post-transplant.

Table of Contents

General Principles
Pathophysiology of acute GVHD
Pathophysiology of chronic GVHD Kirk Schultz
Animal models of chronic GVHD
Incidence and trends
Clinical manifestations and natural history
Risk factors and predictive models G_rg8n
Biomarkers in prediction and monitoring Ernst
Clinical Management
Diagnosis and staging
Chronic GVHD pharmacology and commonly used drugs
Prevention of chronic GVHD Andrea
Front line treatment of chronic GVHD
Salvage treatment of chronic GVHD
Response measurement
General principles in ancillary and supportive care
Organ Site or System Specific Manifestations
Gastrointestinal (including nutritional support)
Hematologic Corey Cutler
Neurologic Harry Openshaw
Musculoskeletal Li
Metabolic and endocrine effects
Other manifestations
Psycho-social issues Loretta
Secondary and late effects
Quality of life assessments
Special Considerations in Chronic GVHD
Clinical trials design
Unique clinical situations
Pediatric chronic GVHD
Coordination and continuity of interdisciplinary practice
Patient and family education, advocacy, and support groups
Future directions
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