Chronic Graft Versus Host Disease: Interdisciplinary Management

by Edited by Georgia B. Vogelsang , Steven Z. Pavletic

• ISBN13: 9780521884235
• ISBN10: 0521884233
• eBook ISBN(s): 9780511530722
• Edition: 1st
• Format: Hardcover
• Copyright: 2009-04-20
• Publisher: Cambridge University Press

Summary

Chronic graft versus host disease (GVHD) is the most common complication of allogenic bone marrow transplantation. Because of the protracted clinical course of chronic GVHD, transplant centers and hematology/oncology offices are inadequately equipped to manage these immuno-incompetent patients with a multi-system disorder. Practitioners need to be able to recognize and effectively manage chronic GVHD as a late effect of more than half of allogenic transplantations. The text is oriented for the clinician, with chapters covering staging, organ site and system-specific manifestations, treatment options, and supportive care. Drs. Georgia B. Vogelsang and Steven Z. Pavletic have been pioneers in the recognition of the multi-organ complexity of this disease and have gathered the input of a variety of subspecialist physicians for this book. This book fills the gap in practical literature on chronic GVHD, providing a comprehensive, up-to-date, and clinically relevant resource for anyone who deals with cancer patients post-transplant.

Table of Contents

General Principles

History

Pathophysiology of acute GVHD

Pathophysiology of chronic GVHD Kirk Schultz

Animal models of chronic GVHD

Incidence and trends

Clinical manifestations and natural history

Risk factors and predictive models G_rg8n

Biomarkers in prediction and monitoring Ernst

Clinical Management

Diagnosis and staging

Chronic GVHD pharmacology and commonly used drugs

Prevention of chronic GVHD Andrea

Front line treatment of chronic GVHD

Salvage treatment of chronic GVHD

Response measurement

General principles in ancillary and supportive care

Organ Site or System Specific Manifestations

Skin

Mouth

Eyes

Genitalia

Gastrointestinal (including nutritional support)

Pulmonary

Hematologic Corey Cutler

Neurologic Harry Openshaw

Musculoskeletal Li

Infections

Metabolic and endocrine effects

Other manifestations

Psycho-social issues Loretta

Secondary and late effects

Quality of life assessments

Special Considerations in Chronic GVHD

Clinical trials design

Unique clinical situations

Pediatric chronic GVHD

Coordination and continuity of interdisciplinary practice

Patient and family education, advocacy, and support groups

Future directions

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