Chronic Lymphocytic Leukemia

by Faguet, Guy B.

• ISBN13: 9781588290991
• ISBN10: 1588290999
• Format: Hardcover
• Copyright: 2003-11-01
• Publisher: Humana Pr Inc

Summary

A comprehensive and critical review of the latest scientific advances in our understanding of the molecular genetics and biology of CLL and their application to the best management of CLL. The authors focus on diagnosis, prognosis, multifaceted treatment options, and complications. Among the diverse treatments considered are chemotherapy, autologous and allogenic transplantations, monoclonal antibody therapy, immunotoxin therapy, gene therapy, and several new therapeutic strategies. Familial and juvenile chronic lymphocytic leukemia are also discussed.

Table of Contents

Preface	v
Contributors	xiii
Part I. Introduction
The Natural History of CLL: Historical Perspective	3	(54)
Gerald E. Marti
Vincent Zenger
Part II. Biology and Genetics
Genetics of B-Cell Chronic Lymphocytic Leukemia	57	(20)
Stephan Stilgenbauer
Peter Lichter
Hartmut Dohner
Molecular Biology of Chronic Lymphocytic Leukemia	77	(18)
William G. Wierda
The Heterogeneous Origin of the B-CLL Cell	95	(14)
Terry Hamblin
Pathogenesis of Impaired Cellular Immune Function in CLL	109	(14)
Patrick B. Johnston
Neil E. Kay
Cytokines and Soluble Molecules in CLL	123	(22)
Enrica Orsini
Robin Foa
Part III. Clinical Aspects: Diagnosis
Immunophenotypic Differential Diagnosis and Cell Cycle Analysis	145	(18)
Vonda K. Douglas
Raul C. Braylan
Common Cytogenetic Abnormalities	163	(10)
Gunnar Juliusson
Immunophenotypic Diagnosis of Leukemic B-Cell Chronic Lymphoproliferative Disorders Other Than Chronic Lymphocytic Leukemia	173	(20)
Alberto Orfao
Julia Almeida
Maria Luz Sanchez
Jesus F. San Miguel
Part IV. Clinical Aspects: Prognosis
Staging of Chronic Lymphocytic Leukemia	193	(8)
Kanti R. Rai
Niraj Gupta
Prognostic Indicators of Chronic Lymphocytic Leukemia	201	(18)
Francesc Bosch
Emili Montserrat
Part V. Clinical Aspects: Treatment
Guidelines for Clinical Management of CLL	219	(22)
Guillaume Dighiero
Chemotherapy of Chronic Lymphocytic Leukemia	241	(14)
Alessandra Ferrajoli
Michael J. Keating
Susan M. O'Brien
Autologous and Allogeneic Transplantations for Chronic Lymphocytic Leukemia	255	(14)
Mauricette Michallet
Monoclonal Antibody Therapy in Chronic Lymphocytic Leukemia	269	(30)
Thomas S. Lin
Margaret S. Lucas
John C. Byrd
Immunotoxin Therapy of Chronic Lymphocytic Leukemia	299	(16)
Arthur E. Frankel
Robert J. Kreitman
New Treatment Strategies in Chronic Lymphocytic Leukemia	315	(14)
Upendra P. Hegde
Wyndham H. Wilson
Gene Therapy of Chronic Lymphocytic Leukemia	329	(14)
Januario E. Castro
Thomas J. Kipps
Part VI. Clinical Aspects: Complications
Infections in Patients With Chronic Lymphocytic Leukemia	343	(18)
Gerald P. Bodey
Dimitrios Kontoyiannis
Michael J. Keating
Autoimmune and Hypersplenic Cytopenias	361	(16)
Terry Hamblin
Clonal Evolution and Second Malignancies in B-CLL	377	(12)
Guy B. Faguet
Part VII. Familial and Juvenile Chronic Lymphocytic Leukemia
Inherited Predisposition to Chronic Lymphocytic Leukemia	389	(12)
Martin R. Yuille
Daniel Catovsky
Richard S. Houlston
Young Patients With Chronic Lymphocytic Leukemia	401	(14)
Francesca R. Mauro
Robin Foa
Index	415