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| Welcome Address | p. xi |
| Circulating Nucleic Acids in Plasma and Serum: An Overview | p. 1 |
| Tumor DNA in Plasma and Serum | |
| A Framework for the Molecular Classification of Circulating Tumor Markers | p. 8 |
| Microsatellite Alterations Detected in the Serum of Early Stage Breast Cancer Patients | p. 22 |
| A Possible Noninvasive Method for the Detection of Bladder Cancer in Patients: Microsatellite Analysis of Free DNA in Urine and Blood | p. 31 |
| Epigenetic Tumor Markers in Plasma and Serum: Biology and Applications to Molecular Diagnosis and Disease Monitoring | p. 36 |
| DNA-Based Detection of Prostate Cancer in Blood, Urine, and Ejaculates | p. 51 |
| Viral DNA as a Tumor Marker | |
| Serum/Plasma Viral DNA: Mechanisms and Diagnostic Applications to Nasopharyngeal and Cervical Carcinoma | p. 59 |
| Quantitative Analysis of Epstein-Barr Virus DNA in Plasma and Serum: Applications to Tumor Detection and Monitoring | p. 68 |
| Remarkable Application of Serum EBV EBER-1 in Monitoring Response of Nasopharyngeal Cancer Patients to Salvage Chemotherapy | p. 73 |
| Circulating Cell-Free Epstein-Barr Virus DNA Levels in Patients with EBV-Associated Lymphoid Malignancies | p. 80 |
| Gross Elevation of TT Virus Genome Load in the Peripheral Blood Mononuclear Cells of Cancer Patients | p. 84 |
| Other Approaches for Cancer Detection | |
| Circulating Nucleosomes in Serum | p. 93 |
| Proteomic Approaches within the NCI Early Detection Research Network for the Discovery and Identification of Cancer biomarkers | p. 103 |
| Detection of Circulating CEA Molecules in Human Sera and Leukopheresis of Peripheral Blood Stem Cells with E. coli Expressed Bispecific CEAScFv-Streptavidin Fusion Protein-Based Immuno-PCR Technique | p. 116 |
| Fetal DNA and Cells in Maternal Blood | |
| Fetomaternal Cellular and Plasma DNA Trafficking: The Yin and the Yang | p. 119 |
| Quantitative Analysis of Fetal DNA in Maternal Plasma in Pathological Conditions Associated with Placental Abnormalities | p. 132 |
| Circulatory Fetal and Maternal DNA in Pregnancies at Risk and Those Affected by Preeclampsia | p. 138 |
| Both Maternal and Fetal Cell-Free DNA in Plasma Fluctuate | p. 141 |
| Use of Annexin V Antibody to Identify Apoptotic Cells during Pregnancy | p. 145 |
| Detection of Fetal NRBCs in Maternal Blood of Pregnant Carriers of [beta]-Thalassemia Using Anti-[gamma] and Anti-[epsiv] Monoclonal Antibodies | p. 151 |
| Fetal DNA Diagnosis from Maternal Blood: PEP-TaqMan PCR Analysis of a Single Nucleated Erythrocyte (NRBC) | p. 153 |
| Technical Optimization of RhD Zygosity Determination by Real-Time Quantitative Polymerase Chain Reaction: Implication for Fetal RhD Status Determination by Maternal Plasma | p. 156 |
| Detection of Maternal DNA in Umbilical Cord Plasma by Fluorescent PCR Amplification of Short Tandem Repeat Sequences | p. 161 |
| From the Simple Detection of Microchimerism in Patients with Autoimmune Diseases to Its Implication in Pathogenesis | p. 164 |
| Circulating RNA in Plasma and Serum: Towards Noninvasive Gene Expression Profiling | |
| Circulating RNA as a Tumor Marker: Detection of 5T4 mRNA in Breast and Lung Cancer Patient Serum | p. 172 |
| Detection of Amplifiable Messenger RNA in the Serum of Patients with Lung Cancer | p. 179 |
| Detection of Tumor-Associated Circulating mRNA in Patients with Disseminated Malignant Melanoma | p. 189 |
| Detection of Mammaglobin mRNA in the Plasma of Breast Cancer Patients | p. 192 |
| Hepatitis B Virus Nucleic Acids Circulating in the Blood: Distinct Patterns in HBs Carriers with Hepatocellular Carcinoma | p. 195 |
| Circulating Fetal RNA in Maternal Plasma | p. 207 |
| New Applications of Circulating DNA | |
| Derivation of a Prediction Rule for Posttraumatic Organ Failure Using Plasma DNA and Other Variables | p. 211 |
| Low-Molecular-Weight DNA in Blood Plasma as an Index of the Influence of Ionizing Radiation | p. 221 |
| Postradiation DNA Polymorphism | p. 229 |
| Detection of Plasmodium falciparum DNA in Plasma | p. 234 |
| Urinary DNA | |
| Circulating Nucleic Acids and Apoptosis | p. 239 |
| Cell-Free DNA in Urine: A Marker for Kidney Graft Rejection, but Not for Prenatal Diagnosis? | p. 250 |
| Biological Issues in Circulating Nucleic Acids | |
| Alu Repeat Sequences Are Present in Increased Proportions Compared to a Unique Gene in Plasma/Serum DNA: Evidence for a Preferential Release from Viable Cells? | p. 258 |
| Functionality of Circulating DNA: The Hypothesis of Genometastasis | p. 265 |
| Foreign DNA Integration--Perturbations of the Genome--Oncogenesis | p. 276 |
| Possible Origin of Extrachromosomal DNA from Human Lymphocytes Following In Vitro Treatment by Phytohemagglutinin | p. 289 |
| Index of Contributors | p. 293 |
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