Click Chemistry in Glycoscience : New Developments and Strategies

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  • Format: Hardcover
  • Copyright: 2013-03-18
  • Publisher: Wiley

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The first text to focus on the application of click chemistry to glycoscience, this book discusses the therapeutic and pharmacological aspects of carbohydrate click chemistry and includes chapters on the concepts background, as well as its industrial applications in areas such as drug discovery. The book reflects the novel methodologies and strategies of this concept. Each chapter describes new approaches, ideas, consequences, and applications deriving from the introduction of click processes. This provides an essential reference for a wide range of researchers and graduate-level students.

Author Biography

ZBIGNIEW J. WITCZAK, PhD, is Professor in the Department of Pharmaceutical Sciences of the Nesbitt School of Pharmacy at Wilkes University. He has published over ninety research papers and holds six patents. His research focuses on carbohydrate synthons, including levoglucosenone and L-arabinose, as templates for carbohydrate-based therapeutics. In 2000, Dr. Witczak was awarded the Melville L. Wolfrom Award from the ACS Division of Carbohydrate Chemistry.

ROMAN BIELSKI, PhD, is Senior Scientist at Value Recovery, Inc., Partner in Cheminnolab, LLC, and Adjunct Professor in the Department of Pharmaceutical Sciences at Wilkes University. His research investigates the origin of homochirality, modification of carbohydrates, solutions to environmental issues, and sustainability. As part of his achievements, Dr. Bielski co-developed a method of enantiomers' resolution, which might have been involved in prebiotic homochirality, since it would not require the use of chiral compounds.

Table of Contents




List of Abbreviations

Click chemistry strategies and decoupling

Chapter 1.  Paradigm and advantage of carbohydrate click chemistry strategy for future decoupling
Roman Bielski, Zbigniew J. Witczak

Thio-click chemistry of carbohydrates

Chapter 2.  Thio-click Chemistry Overviews and Perspectives
Zbigniew J. Witczak

Chapter 3.  Free-Radical Photoinduced Thiol-Ene and Thiol-Yne Coupling as Click Processes for Glycoconjugation
Alessandro Dondoni, Alberto Marra.

Carbohydrate click chemistry for novel synthetic targets

Chapter 4. The Development and application of clickable lipid analogs for elucidating lipid Function
Michael Best

Chapter 5. Clicking Sugars onto sugars: Oligosaccharide Analogue and Glycoclusters on Carbohydrate Fcaffolds
Maria Laura Uhrig, Jose Kovensky

Chapter 6 Click Multivalent Glycomaterials: Glycoclusters, Glycodendrimers, Glycopolymers, Hybrid Glycomatrials and Glycosurfaces
Carmen Ortiz Mellet, Alejandro Mendez-Ardoy, Jose Manuel Garcia Fernandez

Chapter 7. Toward Imaging Glycotools by Click Coupling
Yves Chapleur, Christine Vala, Sandrine Lamande-Langle

Chapter 8   Bioorthogonal Reactions for Labeling Glycoconjugates
Frederic Friscourt, Geert-Jan Boons

Chapter 9. Sweet Sucrose Macrocycles via Click Chemistry Route
Mykhaylo a. Potopnyk, Slawomir Jarosz

Carbohydrate click chemistry in biomedical sciences 

Chapter 10. Chapter 8. Neoglycoprotein Synthesis using Copper-catalyzed Azide-Alkyne Click reaction and Native Chemical Ligation
Joanna M. Wojnar, Dong Jun Lee, Clive W. Evans, Kalyaneswar Mandal, Stephen B.H. Kent Margaret A. Brimble

Chapter 11. Click-modified Cyclodextrin for Biomedical Application
Dang Wang

Chapter 12. Traizolyl Glycoconjugates in Medicnal Chemistry
Rama Pati Tripathi, Pratibha  Dwivedi, Anindra Sharma, Divya Kushwaha Vinod Kumar Tiwari

Chapter 13. Click Chemistry Applied to Carbohydrate-based Drug Discovery
Vanness Leiria Campo, Ivone Carvalho


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