Clinical Biochemistry: Metabolic and Clinical Aspects

by Marshall, William J.; Bangert, Stephen K.

• ISBN13: 9780443101861
• ISBN10: 0443101868
• Edition: 2nd
• Format: Paperback
• Copyright: 2008-06-20
• Publisher: Elsevier Science Health Science

Summary

Essential reading for candidates for the MRCPath examination and similar postgraduate examinations in clinical biochemistry! The book gives an overview of the acquisition of data, as well as concentrating on clinical aspects of the subject, giving detailed coverage of all conditions where clinical biochemistry is used in diagnosis and management. In common with other diagnostic specialties clinical biochemistry now uses an increasing number of techniques involving the 'new biology': these are covered in this book. It is also increasingly common for medically qualified clinical biochemists to become involved in the clinical management of patients (eg nutritional support) and material on this will be included. Significant changes to content to reflect changes in how clinical chemistry services are organised and to reflect the advent of metabolic medicine as a recognised specialty. Chapter on Clinical biochemistry of nutrition to include new information on regulation of appetite and the clinical management of obesity. New chapter to bring together information on inborn errors of metabolism affecting adults. New chapter on clinical biochemistry of cardiovascular disease. The diabetes chapter will be split into two separate chapters to allow more detailed description of the practical clinical management of the disease.

Table of Contents

The uses of biochemical data in clinical medicine

The acquisition of biochemical data

The interpretation of biochemical data

Sodium, water and potassium

Hydrogen ion homoeostasis, tissue oxygenation and their disorders

Calcium, phosphate and magnesium

The kidneys, renal function and renal failure

Proteinuria

Renal tubular disorders and renal stone disease

The clinical biochemistry of nutrition

Nutritional disorders and their management

The clinical biochemistry of the gastrointestinal tract

The assessment of hepatic function and investigation of jaundice

Acute and chronic liver disease

Diabetes mellitus: pathophysiology and biochemical background

The clinical management of diabetes mellitus

Hypoglycaemia

Hypothalamic, pituitary and adrenal disorders

Thyroid dysfunction

Hormonal aspects of non-endocrine disease

Abnormal sexual development

The clinical biochemistry of female reproductive function, including pregnancy, oral contraception and hormone replacement therapy

Reproductive function in the male

Inherited metabolic disease

Paediatric clinical biochemistry

Biochemical aspects of anaemia

The porthyrias and disorders of haem synthesis

The haemoglobulinopathies

Immunology for clinical biochemists

Metabolic bone disease

Biochemical aspects of articular disease

Muscle disease

Investigation of cerebrospinal fluid

Biochemical aspects of psychiatric disorders

Biochemical aspects of neurological disease

Biochemical aspects of mental retardation

Lipid metabolism, hyper- and hypo-lipidaemias

The clinical biochemistry of the cardiovascular system

Therapeutic drug monitoring

Poisoning

Metabolic effects of tumours

Tumour markers

Molecular clinical biochemistry

Free radicals

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