Clinical Chemistry Laboratory Management and Clinical Correlations

by Lewandrowski, Kent B.

• ISBN13: 9780683300857
• ISBN10: 0683300857
• Edition: 1st
• Format: Hardcover
• Copyright: 2002-04-22
• Publisher: LWW

Summary

A modern text that combines the fundamentals of methodology with key elements of interpretation, this book blends business and management issues, analytical principles, and clinical material for practicing pathologists, residents, fellows, and laboratorians. The text is organized into three major sections: laboratory management, instrumentation and methods, and analysis and clinical correlation. The first section addresses issues essential for running a profitable laboratory; modern techniques and instrumentation are examined in the second section; and the analysis and clinical correlation section provides the reader with numerous diagnostic algorithms that illustrate common work-ups and problems. In addition, case studies selectively illuminate specific clinical issues.

Table of Contents

Contributing Authors	xi
Preface	xv
SECTION I: LABORATORY MANAGEMENT	1	(356)
Overview of Laboratory Management: An Introduction and Perspective	3	(10)
Kent Lewandrowski
Accreditation and Regulation in the Clinical Laboratory	13	(12)
Donna H. MacMillan
Human Resources Management	25	(15)
Diane Cosmidis
Elizabeth Taylor
Kent Lewandrowski
Laboratory Safety: An Overview	40	(11)
J. Keith Joung
Kent Lewandrowski
The Laboratory Manager: Role in Compliance, Organizational Structure, and financial Management	51	(13)
Lawrence J. Crolla
Paul W Stiffler
Sheryl Vacca
A. Stephanie M. McNear
Budget Management and Benchmarking	64	(7)
William M. Hynes
Dion S. Buchner
Cost Accounting in the Clinical Laboratory	71	(10)
Dion S. Buchner
William M. Hynes
Quality Control / Quality Assurance	81	(26)
Frank H. Wians, Jr.
David D. Koch
Amy Haara
Diagnostic Accuracy of Laboratory Tests and the Establishment of Reference Ranges	107	(15)
Eleftherios C. Vamvakas
Method Evaluation and Technology Assessment	122	(30)
Pennell C. Painter
Operations Analysis, Reengineering, and Process Improvement	152	(13)
Peter R. Ciment
Reimbursement for Laboratory Services	165	(10)
Donna H. MacMillan
Point-of Care Testing	175	(20)
James H. Nichols
Specimen Transport, Logistics, and Processing	195	(10)
Antony O. Okorodudu
M. Tarek Elghetany
Integrated Automation in the Clinical Laboratory	205	(7)
Lokinendi V. Rao
Antony O. Okorodudu
Development of Laboratory Instrument Platforms	212	(15)
Roy Marcus
Assay Development and the Role of the FDA	227	(10)
Alan E. Burkhardt
Part One. Overview of Laboratory Information Systems: Computing Knowledge for the Laboratorian	237	(73)
H. Dominic Covvey
Joseph J. Stumpf
Part Two. Management and the Laboratory Information System	284	(26)
H. Dominic Covvey
Joseph J. Stumpf
Role of Laboratories in Integrated Delivery Networks	310	(7)
William M. Hynes
The Commercial Reference Laboratory	317	(6)
Geraldine M. Beyer
Kent Lewandrowski
Management of Test Utilization	323	(8)
M. Tarek Elghetany
Anthony O. Okorodudu
Acute Care and STAT Laboratory Testing	331	(16)
Ellis Jacobs
The Role of the Diagnostics Industry in the Clinical Chemistry Laboratory	347	(10)
Michael D. Noyt
SECTION II: INSTRUMENTATION AND METHODS	357	(172)
Darryl Erik Palmer-Toy
General Laboratory Techniques, Units of Measurement, and a Table of Representative Normal Reference Values	359	(16)
Kent Lewandrowski
Alexander Kratz
Contemporary Instruments in the Clinical Laboratory: A Brief Overview	375	(10)
Elizabeth Lee-Lewandrowski
Kent Lewandrowski
Photometric Methods, Fluorometry, Atomic Absorption, Nephelometry, and Turbidimetry	385	(18)
Steven M. Faynor
William C. Bastan
Mass Spectrometry	403	(10)
Peter E. Leopold
Darryl Erik Palmer-Toy
An Introduction to Clinical Laboratory Immunodiagnostics: A Perspective from the Diagnostics Industry	413	(16)
George Parsons
Immunoassay and Immunoassay Analyzers: A Perspective from the Clinical Laboratory	429	(10)
Bode B. Adesoji
John R. Petersen
Chromatography and Capillary Electrophoresis: Principles and Practical Consideration	439	(14)
Zak K. Shihabi
Electrochemistry	453	(15)
Paul D'Orazio
Electrophoresis	468	(13)
Rita Ellerbrook
Measurement of Osmolality and Specific Gravity	481	(3)
Kent Lewandrowski
Molecular Diagnostics: Methods and Applications	484	(16)
James Versalovic
Clinical Enzymology	500	(21)
Kelly Y. Chun
Radioimmunoassay	521	(8)
Patrick M. Sluss
SECTION III: ANALYSIS AND CLINICAL CORRELATIONS	529	(406)
The Plasma Proteins	531	(30)
Alexander Kratz
Elizabeth Lee-Lewandrowski
Kent lewandrowski
Glucose and Carbohydrates	561	(14)
Kenneth Emancipator
Lipids, Lipoproteins, and Cardiovascular Risk Assessment	575	(17)
Gyorgy Abel
Michael Laposata
Laboratory Diagnosis of Disorders of the Thyroid Gland	592	(14)
Yash P. Agrawal
Kent Lewandrowski
Laboratory Evaluation of Pituitary Disorders, Adrenal Cortex and Medulla, and Selected Neuroendocrine Tumors	606	(19)
Yash P. Agrawal
Kent Lewandrowski
Reproductive Endocrinology	625	(14)
Frances Hayes
Sabrina Gill
Patrick M Sluss
Acid-Base and Electrolyte Disorders	639	(20)
Kent Lewandrowski
Respiration and the Evaluation of Hypoxemia, Hypercapnia, and Related Disorders	659	(12)
Kent Lewandrowski
Michael Pins
Robert W. Burnett
Cardiac Markers	671	(18)
Alan H.B. Wu
Renal Function and Nitrogen Metabolites	689	(21)
Zbigniew M. Szczepiorkowski
Kent Lewandrowski
Calcium, Magnesium, and Phosphate	710	(15)
John G. Toffaletti
Evaluation of Hepatic Function and Disorders of the Liver	725	(25)
David R. Coon
Kent Lewandrowski
Inborn Errors of Metabolism	750	(17)
Tina M. Cowan
Miriam G. Blitzer
Toxicology Testing in the Clinical Laboratory	767	(17)
Jane Yang
Therapeutic Drug Monitoring	784	(12)
Jane Yang
Kent Lewandrowski
Trace Elements, Vitamins, and Nutrition	796	(29)
Jane Yang
Kent Lewandrowski
Disorders of Porphyrin Synthesis and of Iron Metabolism	825	(16)
Gyorgy Abel
Anil Parwani
Human Chorionic Gonadrotropin and Clinical Laboratory Testing in the Diagnosis and Management of Pregnancy	841	(8)
Alexander Kratz
Jane Yang
Kent Lewandrowski
Clinical Chemistry of Urine, Pleural Effusions, and Ascites	849	(16)
William Clarke
Darryl Erik Palmer-Toy
Tumor Markers	865	(12)
Morton K. Schwartz
Cerebrospinal Fluid	877	(15)
Philip J. Boyer
Zachary Simmons
Thomas P. Nifong
Coagulation	892	(20)
Elizabeth M. Van Cott
Disorders of Bone Chemistry and Clinical Correlations	912	(6)
Kent Lewandrowski
Laboratory Evaluation of Pancreatic Disorders, Malabsorption, and Diseases of the Gastrointestinal System	918	(17)
Kent Lewandrowski
Darryl Erik Palmer-Toy
James Versalovic
Subject Index	935