Clinical Dilemmas in Primary Liver Cancer

by Williams, Roger; Taylor-Robinson, Simon D.

• ISBN13: 9780470657973
• ISBN10: 0470657979
• Edition: 1st
• Format: Paperback
• Copyright: 2011-12-27
• Publisher: Wiley-Blackwell

Summary

Clinical Dilemmas in Liver Cancer follows the successful format of the other books in the Clinical Dilemmas series, with each chapter focused on a specific dilemma, or issue facing doctors in their day-to-day job, and providing them with practical clinical information and help to better assessment and treat their patients - in this case patients suffering from liver cancer, the third commonest cancer in terms of mortality worldwide. Chapters feature up-to-date information on the basic mechanisms, epidemiological risk factors, screening and surveillance strategies, diagnosis and treatment. It is an extremely practical and clinically-orientated book, and as most patients around the world present with advanced disease, a main focus is on the most recent advances allowing early diagnosis and use of locoregional and systemic therapy, surgery, transplantation and combination therapies. Each chapter is authored by an international expert in the relevant area.

Author Biography

Professor Roger Williams CBE, runs the Institute of Hepatology at UCL, and is a twice former president of EASL. He has authored an incredible 2100 journal articles. Despite advancing years, he is still actively involved in clinical research–340 articles in the past ten years, and analysis by ISI shows him to be one of the most influential researchers in his field. The award of a CBE for services to medicine recognised his major contribution to the study of liver disorders over 25 years including leading the team who performed the first ever liver transplant in the UK. Prof Williams has had many awards, medals, honorary fellowships, and in 2006 was included by HRH The Queen in a celebration at Buckingham Palace to honour those who continue to contribute to public service beyond the age of 65yrs. He was made a Fellow of King's College London in 1992 and an Honorary Fellowship from UCL was conferred on him in 2008, in recognition of his distinguished career and outstanding service to UCL.

Professor Simon Taylor-Robinson joined the Department of Medicine at Imperial College London in 1997, having previously been Senior Registrar in Gastroenterology and Hepatology at Hammersmith Hospital. He was awarded the Sir Francis Avery Jones Gold Medal by the British Society of Gastroenterology in 1999 and the Young Investigator Award of the Liver Section of the European Gastroenterology Association in 1997. He is currently Director of the Imperial Clinical Research Facility at St Mary's Hospital, London.

Table of Contents

List of Contributors

Preface

Learning from a Worldwide Perspective

Are patterns and prevalence changing?

Why is the tumour different in Africa?

Control by vaccination: Asian and Taiwan experience

The view from the UK

The view from the United States

New challenges of NAFLD and HIV epidemics

Influence of Tumour Characteristics

Controversies in Pathology

Not to forget the unusual tumour

What can be learned from molecular diagnostic techniques and genetic signatures?

Complexities of Patient Assessment and Scoring Systems

Looking after the liver as well as the tumour

Comparative performances of staging systems for hepatocellular cancer: Early HCC considerations

Rival scoring systems: Do they offer more?

Is it possible to detect early lesions effectively?

What is the value of country based surveillance programmes?

Choice of Radiological Diagnostic Technique

Computed tomography or magnetic resonance imaging for the diagnosis of hepatocellular carcinoma

Is Microbubble ultrasound useful?

Value of PET scanning

Can Treatment be Tailored to the Patient?

Who could benefit from chemoembolisation?

Are drug eluting beads (DEB) worth using?

What's the future of image-guided radiofrequency ablation for hepatocellular carcinoma?

Alternative ablation techniques for hepatocellular carcinoma

Justification for Sorafenib and chemotherapy

When to consider surgery?

Transplant considerations

What Does the Future Hold?

Dipstick markers for diagnosis: Feasible or not?

Targeted gene therapy for hepatocellular carcinoma (HCC): A reality?

Is immune modulation a possibility?

Systemic therapy for hepatocellular carcinoma: Future directions

Table of Contents provided by Publisher. All Rights Reserved.