Clinical Guide to the Use of Antithrombotic Drugs in Coronary Artery Disease

by Angiolillo; Dominick

• ISBN13: 9781841846392
• ISBN10: 1841846392
• Edition: 1st
• Format: Hardcover
• Copyright: 2008-04-08
• Publisher: CRC Press

Summary

Atherothrombotic disease is the leading cause of morbidity and mortality; therefore, anti-thrombotic agents play a pivotal role in primary and secondary prevention of atherothrombotic complications. In A Clinical Guide to the Use of Antithrombotic Drugs, three main sections in the field have been elaborated. In the first, 3 chapters on basics concepts of atherothrombosis are examined. The objectives of these chapters are to provide pathophysiological concepts on atherothrombosis useful to the practicing clinician to understand the rationale for using antithrombotic agents in daily practice. In the second section, 16 chapters describe 4 main categories of antithombotic agents used in clinical practice: oral antiplatelet agents, intravenous antiplatelet agents, thrombin inhibitors, and fibrinolytics. In each category, description and clinical application of currently approved agents as well as agents under clinical investigation are described. The objectives of this section are to provide the state of the artknowledge on antithrombotic drug use and development. In the third section, a series of 8 chapters examines the application of antithrombotic agents in specific clinical scenarios. The objective of this section is to provide practical insights on how to apply antithrombotic agents in the context of daily clinical scenarios. Overall, this compendium provides a valuable tool for clinicians in their daily clinical practice on how to use currently available antithrombotic agents as well as provide insights on the future development in this field.

Table of Contents

Basic Concepts of Atherothrombosis

Fundamentals of the Thrombosis Cascade

Role of Platelets in Atherothrombosis

Laboratory Assessments of Platelet Function and Coagulation

Antithrombotic Drugs

Cycloxygenase Inhibition in Atherothrombotic Disease

P2Y 12 Antagonism with Clopidogrel: from bench to bedside

Timign, Dosing and Length of Clopidogrel Therapy

Resistance to Clopidogrel

Resistance to Aspirin

Prasugrel: an Emerging Thienopyridine

Direct Oral P2Y 12 Inhibition (AZD6140)

Picotamide and Other Emerging Oral Platelet Inhibitors (PAR-antagonists, Nocorandil)

When and Which GP IIb/IIIa Inhibitors to Use in ACS/PCI?

Cangrelor

Unfractionated Heparin or LMWH in PCI: which one to choose, what does and when?

Fondaparinux in ACS

Direct Thrombin Inhibitors During PCI

Tissue Factor Pathway Inhibitors

Fibrinolytics: do they still play a role in the era of mechanical reperfusion? Current ndications and Treatment Modalities

Fibrinolysis and PCI

Special Situations

Facilitated PCI

Role of Antithrombotic Agents and Devices in Saphenvous Vein Graft Disease and Thrombus-containing Lesions

Targeting the Diabetic Patient

Antithrombotic Treatment in Women

Managing Stent Thrombosis

Managing Bleeding Complications, Thrombocytopenia, Bleeding Issues Surrounding CABG

HIT

Anti-thrombotic Therapies for Stroke Prevention: can we borrow from coronary artery disease?

Appendix

Appendix

Antithrombotic Drugs. Recommendations in UA/NSTEMI Appendix

Antithrombotic Drugs. Recommendations in STEMI Appendix

Antithrombotic Drugs. Recommendations in PCI Appendix

Antithrombotic Drugs. Recommended Doses

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