Clinical Immunology : Principles and Practice

by Rich, Robert R.; Fleisher, Thomas T.; Shearer, William T.; Schroeder, Harry W., Jr., M.D., Ph.D.

• ISBN13: 9780323044042
• ISBN10: 0323044042
• Edition: 3rd
• Format: Hardcover
• Copyright: 2008-04-15
• Publisher: Elsevier Science Health Science div

Summary

Written and edited by international leaders in the field, this book has, through two best-selling editions, been the place to turn for authoritative answers to your toughest challenges in clinical immunology. Now in full color and one single volume, the 3rd Edition brings you the very latest immunology knowledge - so you can offer your patients the best possible care. The user-friendly book and the fully searchable companion web site give you two ways to find the answers you need quickly...and regular online updates keep you absolutely current. Leading international experts equip you with peerless advice and global best practices to enhance your diagnosis and management of a full range of immunologic problems. A highly clinical focus and an extremely practical organization expedite access to the answers you need in your daily practice. Cutting-edge coverage of the human genome project, immune-modifier drugs, and many other vital updates keeps you at the forefront of your field. A new organization places scientific and clinical material side by side, to simplify your research and highlight the clinical relevance of the topics covered. A multimedia format allows you to find information conveniently, both inside the exceptionally user-friendly book and at the fully searchable companion web site. Regular updates online ensure that you'll always have the latest knowledge at your fingertips. Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.

Table of Contents

Fundamental Principles of the Immune Response

The human immune response

Organization of the immune system

Innate immunity

Antigen receptor genes, gene products, and co-receptors

The major histocompatibility complex

Antigens and antigen processing

Antigen-presenting cells and antigen presentation

B-cell development and differentiation

T-cell development

Cytokines and cytokine receptors

Chemokines and chemokine receptors

Lymphocyte adhesion and trafficking

T-cell activation and tolerance

Programmed cell death in lymphocytes

Host Defense Mechanisms and Inflammation

Immunoglobulin function

Regulatory T cells

Helper T-cell subsets and control of the inflammatory response

Cytotoxic lymphocyte function and natural killer cells

Host defenses at mucosal surfaces

Complement and complement deficiencies

Phagocytes and phagocyte deficiencies

Mast cells, basophils and mastocytosis

Eosinophils and eosinophilia

Infection and Immunity

Immune response to extracellular bacteria

Immune responses to intracellular bacteria

Immune responses to spirochetes

Immune responses to viruses

I mmune responses to protozoans

Immune responses to helminths

Immunologic Deficiencies

Evaluation of the immunodeficient patient

Infections in the immunocompromised host

Development of the fetal and neonatal immune system

Aging and the immune system

Primary antibody deficiencies

Primary T-cell immunodeficiencies

Inherited disorders of IFN-¿-, IFN-¿/ß-, and NF-¿B-mediated immunity

HIV infection and acquired immunodeficiency syndrome

Immunodeficiency due to congenital, metabolic, infectious, surgical, and environmental factors

Allergic Diseases

Pathogenesis of asthma

Management of the asthmatic patient

Rhinitis and sinusitus

Urticaria, angiodema, and anaphylaxis

Allergic reactions to stinging and biting insects

Atopic and contact dermatitis

Food allergy 46 Eosinophil-associated gastrointestinal disorders (EGID )

Allergic disorders of the eye

Drug hypersensitivity

Occupational and environmental allergic disorders

Systemic Immune Diseases

Mechanisms of autoimmunity

S ystemic lupus erythematosus

Rheumatoid arthritis

Juvenile idiopathic arthritis

Sjogrens syndrome

Systemic sclerosis

Inflammatory muscle diseases

Spondyloarthritis

Small- and medium-vessel primary vasculitis

Large-vessel vasculitides

Autoinflammatory fever syndromes

Antiphospholipid syndrome

Organ Specific Inflammatory Disease

Immunohematologic disorders

Bullous diseases of the skin and mucous membranes

Myasthenia gravis

Multiple sclerosis

Autoimmune peripheral neuropathies

Immunologic renal diseases

Inflammation and atherothrombosis

Autoimmune thyroid diseases

Diabetes and related autoimmune diseases

Immunologic lung diseases

Sarcoidosis

Immunologic ocular disease

Immunologic disease of the gastrointesinal tract

Inflammatory hepatobiliary cirrhosis

Neoplasia and the Immune System

Lymphoid leukemias

Lymphomas including Hodgkin lymphoma

Monoclonal gammopathies

Tumor immunology and immunotherapy

Transplantation

Concepts and challenges in transplantation: rejection, immunosuppression and tolerance

Challenges and potentials of xenotransplantation

Hematopoietic stem cell transplantation for malignant diseases

Stem cell transplantation and immune reconstitution in immunodefic

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