Clinical Infectious Diseases A Practical Approach

by Root, Richard K.; Waldvogel, Francis; Corey, Lawrence; Stamm, Walter E.

• ISBN13: 9780195081039
• ISBN10: 019508103X
• Format: Hardcover
• Copyright: 1998-12-24
• Publisher: Oxford University Press

Summary

Until now, those in need of information on infectious diseases had to choose between encyclopedic reference texts or the infectious diseases sections in standard textbooks in internal medicine. Now there is a better alternative-Clinical Infectious Diseases fills the long-standing need for apractical yet comprehensive work that offers easy, convenient access to the topic. Of interest to internists, infectious disease specialists, and residents in training, the book is structured to give the reader essential information about the etiology and pathogenesis of various infectious diseases,and focuses on the clinical issues of managing, diagnosing, and treating patients with all types of infection. The editors and contributors are internationally known and recognized experts, and aim to validate the increasingly universal approaches to the diagnosis and treatment of infectionsworldwide. Emphasizing the clinical presentation of the patient by organ-system, diagnostic considerations including geographic, anatomic and microbiologic concerns, are addressed in detail. Diagnostic algorithms are provided, and specific choices of antimicrobial therapy are discussed and compiledin a user-friendly tabular format. Preventive measures for different types of infections are also addressed. Sections devoted to infections in special patient/risk groups, such as the post operative patient, the patient with immunodeficiency, the trauma patient, and the burn patient are included, aswell as coverage of infections of travelers to tropical countries, and patients who have been bitten or scratched by animals or insects. A detailed presentation on HIV infection includes discussions of epidemiology, pathogenesis, immunology, clinical manifestations and antiviral treatment, as wellas management of opportunistic infections.

Author Biography

Richard Root, M.D., is Professor and Vice Chairman of the Department of Medicine, University of Washington School of Medicine, and Chief of the Medical Service, Harborview Medical Center, Seattle.
Francis Waldvogel, M.D., is Chairman of the Department of Medicine at the University of Geneva, Switzerland.

Table of Contents

Contributors	xiii
Historical Notes on Infections Disease	1	(6)
Harold P. Lambert
Infectious Diseases: An Overview	7	(12)
Richard K. Root
Part I Pathophysiology of Infectious Diseases
Microbes and Virulence Factors: Bacteria	19	(8)
David A. Relman
Pathophysiology of Viruses and Viral Diseases	27	(10)
David M. Koelle
Lawrence Corey
Parasitic Protozoa and Helminths	37	(6)
Adel A. F. Mahmoud
Fungi and Fungal Diseases	43	(10)
John E. Edwards, Jr.
Peter G. Pappas
Epidemiology in Clinical Infectious Diseases	53	(8)
Richard A. Goodman
James M. Hughes
Epidemiology and Control of Infectious Diseases in Health Care Facilities	61	(10)
Huan J. Chang
William R. Jarvis
Host Responses to Infection: Fever, Hyperthermia, and Hypothermia	71	(12)
Richard K. Root
The Acute Inflammatory Response	83	(8)
Jan Verhoef
The Specific Immune Response	91	(20)
John M. Dwyer
Part II Diagnostic Methods in Infectious Disease
Modern Imaging Techniques in Infectious Disease	111	(10)
Eric J. Stern
Hanh V. Nghiem
John F. Hiehle, Jr.
David H. Lewis
Hematologic Alterations in Infectious Disease Patients	121	(12)
Photis Beris
Francis A. Waldvogel
Metabolic and Endocrine Alterations in Infectious Disease Patients	133	(4)
Francis A. Waldvogel
Specimen Management and Rapid Detection of Infectious Agents	137	(8)
Fred C. Tenover
Clinical Bacteriology	145	(14)
James J. Plorde
Clinical Virology	159	(10)
Rhoda L. Ashley
Clinical Mycology	169	(12)
Michael A. Pfaller
Clinical Parasitology	181	(14)
James J. Plorde
Rickettsia and Chlamydia	195	(14)
W. Conrad Liles
Walter E. Stamm
Part III Antimicrobial Drugs: Principles and Usage
Mechanisms of Antimicrobial Action and Resistance	209	(8)
George A. Jacoby
Pharmacology of Antimicrobials	217	(8)
Sandra L. Preston
George L. Drusano
Antimicrobial Toxicities and Drug Interactions	225	(8)
James E. Leggett
Susan R. Raber
Selection of Antimicrobials for Treatment	233	(8)
Jay P. Sanford
Richard K. Root
Outpatient Parenteral Therapy of Serious Infections	241	(4)
Alan D. Tice
Control of Antimicrobial Usage	245	(4)
Peter G. Davey
Penicillins	249	(8)
Catherine M. Creticos
John N. Sheagren
Cephalosporins	257	(8)
James B. Malow
John N. Sheagren
Other Beta-lactam Antibiotics: Penems, Carbapenems, and Monobactams	265	(8)
Pierre Tattevin
Guillaume Breton
Claude Carbon
Aminoglycosides	273	(12)
David N. Gilbert
Glycopeptides	285	(6)
Adel S. Sulaiman
Robert M. Rakita
Barbara E. Murray
Macrolides and Clindamycin	291	(8)
Howard S. Gold
Robert C. Moellering, Jr.
Tetracyclines and Chloramphenicol	299	(6)
Thomas M. Hooton
Fluoroquinolones	305	(8)
Ralf Stahlmann
Hartmut Lode
Sulfonamides and Trimethoprim	313	(6)
Stephen E. Sanche
Allan R. Ronald
Miscellaneous Antibacterial Drugs	319	(8)
Gordon Dow
Allan R. Ronald
Antimycobacterial Drugs	327	(10)
Charles A. Peloquin
Michael D. Iseman
Antimicrobial Therapy for Bacterial Diseases	337	(12)
David H. Spach
W. Conrad Liles
Antiviral Drugs and Therapy	349	(16)
Catherine Diamond
Lawrence Corey
Antiparasitic Drugs and Therapy	365	(24)
Keith B. Armitage
Antifungal Drugs	389	(8)
Peter G. Pappas
John E. Edwards, Jr.
Selection of Antifungal Drugs for Deep Mycoses	397	(10)
Peter G. Pappas
John E. Edwards, Jr.
Part IV Vaccines and Immunomodulatory Agents
Principles of Vaccine Development and Immunoprophylaxis	407	(4)
Gordon L. Ada
Passive Immunoprophylaxis and Treatment	411	(4)
James E. Pennington
Specific Vaccines	415	(12)
Paul T. Heath
E. Richard Moxon
Growth Factors, Immunomodulators, and Cytokines	427	(12)
Brigitta U. Mueller
Phillip A. Pizzo
Part V Infectious Disease Syndromes
Approach to the Patient with Fever: Acute Febrile Illness	439	(10)
Ethan Rubinstein
David Hassin
Fever in Hospitalized Patients	449	(10)
David N. Schwartz
Robert A. Weinstein
Fever of Unknown Origin	459	(12)
Richard K. Root
Robert G. Petersdorf
Bacteremia, Sepsis, and Septic Shock	471	(12)
Giorgio Zanetti
Jean-Daniel Baumgartner
Michel-Pierre Glauser
Infections with Rash	483	(18)
Morton N. Swartz
Cellulitis and Abscesses	501	(4)
Dennis L. Stevens
Infectious Diseases with Lymphadenopathy	505	(8)
Ivor Byren
Upper Respiratory Tract Infections	513	(10)
Charles B. Smith
Bronchitis and Bronchiectasis	523	(6)
Christoph M. Tang
Christopher P. Conlon
Acute Pneumonia	529	(10)
Feng Yee Chang
Victor L. Yu
Cavitary Pulmonary Disease	539	(18)
John L. Johnson
Jerrold J. Ellner
Diffuse Pulmonary Infiltrates and Acute Respiratory Distress Syndrome	557	(8)
Kenneth P. Steinberg
Pleurisy and Empyema	565	(8)
Hartmut Lode
Tom Schaberg
J. Eller
Intraoral Infections	573	(8)
John S. Greenspan
Deborah Greenspan
Diarrhea and Gastroenteritis	581	(8)
Herbert L. DuPont
Hepatitis	589	(8)
Margaret C. Shuhart
Robert L. Carithers, Jr.
Pyogenic Biliary Tract and Hepatic Infections	597	(8)
Jan V. Hirschmann
Infectious Complications of Pancreatitis	605	(8)
E. Patchen Dellinger
Peritonitis and Intraabdominal Abscesses	613	(8)
E. Patchen Dellinger
Infective Endocarditis	621	(16)
Adolf W. Karchmer
Intravenous Catheter-Related Infections, Suppurative Thrombophlebitis, and Mycotic Aneurysms	637	(6)
Daniel P. Lew
Jacques Schrenzel
Myocarditis and Pericarditis	643	(6)
A. Martin Lerner
Urinary Tract Infections	649	(8)
Walter E. Stamm
Genital Herpes, Syphilis, and Genital Ulcer Disease	657	(12)
H. Hunter Handsfield
Urethritis, Epidydimitis, Orchitis, Prostatitis	669	(12)
Kimberley K. Fox
Susan F. Isbey
Myron S. Cohen
Culley C. Carson III
Vulvovaginitis, Cervicitis, and Pelvic Inflammatory Disease	681	(8)
Joanne E. Embree
Robert C. Brunham
Meningitis	689	(14)
Young S. Kim
Martin G. Tauber
Encephalitis	703	(12)
R. Tyler Frizzell
Richard J. Whitley
Infections Associated with Myelopathy, Radiculopathy, and Neuropathy	715	(8)
Christina M. Marra
Focal Central Nervous System Infections	723	(10)
Allan R. Tunkel
W. Michael Scheld
Ocular and Periocular Infections	733	(8)
Annabelle A. Okada
Ann Sullivan Baker
Osteomyelitis	741	(16)
Jon T. Mader
Mauro Ortiz
Jason H. Calhoun
Infectious and Postinfectious Arthritis	757	(10)
MeKonnen Abebe
Lee D. Kaufman
Benjamin J. Luft
Myositis and Fasciitis	767	(6)
Dennis L. Stevens
Chronic Fatigue Syndrome	773	(10)
Dedra S. Buchwald
Part VI Infections in Special Patient/Risk Groups
Postsurgical Wound Infections	783	(6)
Ronald Lee Nichols
Burn Infections	789	(6)
Roberta Mann
Baiba J. Grube
David M. Heimbach
Infections Complicating Traumatic Injury	795	(6)
Wayne N. Campbell
Prosthetic Device Infections	801	(8)
Werner Zimmerli
Infection in the Immunodeficient Patient	809	(12)
Michel Aoun
Jean Klastersky
Infection in the Organ Transplant Recipient	821	(8)
Robert H. Rubin
Nina E. Tolkoff-Rubin
Hematopoietic Stem Cell Transplantation	829	(10)
Raleigh A. Bowden
Infection in the Malnourished Patient	839	(10)
Philippe Lepage
Achim Schwenk
Patrick De Mol
Jean-Paul Butzler
Intravenous Drug Abuse and Infection	849	(4)
Christian Ruef
Alcohol Abuse, Host Defenses, and Infection	853	(6)
Rob Roy MacGregor
Fever in Travelers to Tropical Countries	859	(16)
W. Conrad Liles
Wesley C. Van Voorhis
Endemic and Traveler's Diarrhea in Tropical Countries	875	(6)
Herbert L. DuPont
Eosinophilia in Travelers to Tropical Countries	881	(4)
Adel A. F. Mahmoud
Infections after Animal Bites and Scratches	885	(6)
Stephen J. Gluckman
Ectoparasite-Related Diseases	891	(14)
David H. Space
Karen M. Van de Velde
Part VII Human Immunodeficiency Virus and AIDS
Epidemiology and Prevention	905	(10)
Francois Crabbe
Marie Laga
Peter Piot
AIDS Pathogenesis: Molecular Biology and Virology of HIV	915	(12)
J. Michael Kilby
George M. Shaw
AIDS Immunology	927	(10)
Sharon A. Stranford
Jay A. Levy
Clinical Manifestations of HIV Infection and AIDS	937	(22)
Ann C. Collier
Christina M. Marra
Lili A. Sacks
Antiretroviral Therapy	959	(6)
Lawrence Corey
Therapy of Opportunistic Infections	965	(12)
Jason I. N. Tokumoto
Harry Hollander
Vaccines	977	(4)
Dani P. Bolognesi
Index	981