Clinical Oncology

by Abeloff, Armitage, Niederhuber, Kastan & McKenna

• ISBN13: 9780443066290
• ISBN10: 0443066299
• Edition: 3rd
• Format: Hardcover
• Copyright: 2004-06-11
• Publisher: Churchill Livingstone

Summary

This completely revised 3rd Edition provides readers with an easy-to-use, comprehensive reference that features a clinical perspective balanced with relevant basic science. Readers will find the latest developments in basic science, pathology, diagnosis, management, outcomes, rehabilitation, and prevention. The addition of basic science editor Michael B. Kastan, MD, PhD ensures complete coverage of essential scientific information, including molecular tools in cancer research, cellular microenvironment, stem cells in cancer susceptibility genes, and more. Plus, a new templated, four-color design with highlighted boxes and algorithms offers easy access to pertinent information. Features the addition of basic science editor Michael B. Kastan, MD, PhD, ensuring complete coverage of essential scientific topics. Discusses the latest advances, including the most current developments in stem cell therapies and new approaches to innovations in diagnosis. Provides new information on geriatric oncology, as well as new chapters on pathology, imaging, and molecularly targeted therapies. Covers the hottest topics in the field, such as molecular tools in cancer research, cellular microenvironment, stem cells in cancer susceptibility genes, and more. Presents a multidisciplinary approach to disease chapters, including a pathologist, radiation oncologist, medical oncologist, and surgeon. Includes a CD-ROM image bank of the text's illustrations downloadable into PowerPoint® presentations. Offers a user-friendly layout with standard chapter templates summary boxes at the beginning of each chapter management "opinion" boxes a new full-color design and over 1,000 full-color illustrations, diagrams, and algorithms. And much more!

Table of Contents

Science of Clinical Oncology	p. 1
Biology and Cancer
Molecular Tools in Cancer Research	p. 3
Intracellular Signaling	p. 19
The Cellular Microenvironment	p. 47
Biology of Cancer Metastasis	p. 59
Control of the Cell Cycle	p. 81
Cell Life and Cell Death	p. 101
Immunology and Cancer	p. 113
Stem Cells, Cell Differentiation, and Cancer	p. 139
Vascular and Interstitial Biology of Tumors	p. 153
The Genesis of Cancer
Environmental Factors	p. 173
DNA Damage Response Pathways and Cancer	p. 191
Viruses and Human Cancer	p. 207
Genetic Factors: Hereditary Cancer Predisposition Syndromes	p. 227
Genetic Factors: Finding Cancer Susceptibility Genes	p. 253
Progressing from Gene Mutations to Cancer	p. 269
Immunodeficiency and Cancer	p. 287
Diagnosing Cancer
Pathology and Laboratory Medicine	p. 299
Surgical Pathology	p. 300
Flow Cytometry in Oncologic Diagnosis	p. 305
Cytogenetics	p. 311
Molecular Diagnostics	p. 320
Clinical Chemistry: Tumor Markers	p. 329
Imaging	p. 341
Preventing and Treating Cancer
Biostatistics for Clinical Trials	p. 365
Structures Supporting Cancer Clinical Trials	p. 383
Economic Analysis of Cancer Treatment	p. 395
Epidemiology and Population Sciences	p. 407
Cancer Prevention, Screening, and Early Detection	p. 425
Smoking Cessation: Current Treatments and Future Directions	p. 473
Chemotherapy	p. 483
The Basics of Radiation Therapy	p. 537
Surgical Interventions in Cancer	p. 579
Bone Marrow Transplantation	p. 591
Gene Therapy in Oncology	p. 603
The Present and Future of Molecularly Targeted Therapy	p. 623
Photodynamic Therapy	p. 639
Therapeutic Antibodies and Immunologic Conjugates	p. 661
Cancer Vaccines	p. 677
Complementary and Alternative Medicine	p. 695
Problems Common to Cancer and Its Therapy	p. 713
Symptom Management and Palliative Care
Cancer Pain	p. 715
Rehabilitation of the Patient with Cancer	p. 731
Cachexia	p. 749
Nausea and Vomiting	p. 759
Oral Complications	p. 775
Alopecia and Cutaneous Complications	p. 793
Lymphedema	p. 817
Fatigue	p. 835
Caring for Patients at the End of Life	p. 847
Hematologic Problems
Disorders of Blood Cell Production in Clinical Oncology	p. 861
Diagnosis, Treatment, and Prevention of Cancer-Related Venous Thrombosis	p. 891
Infections
Fever in the Neutropenic Cancer Patient	p. 925
Infection in the Severely Immunocompromised Patient	p. 941
Metabolic and Paraneoplastic Syndromes
Hypercalcemia	p. 957
Hyponatremia	p. 973
Tumor Lysis Syndrome	p. 987
Paraneoplastic Neurologic Syndromes	p. 993
Surgical Problems
Establishing and Maintaining Vascular Access	p. 1007
Acute Abdomen, Bowel Obstruction, and Fistula	p. 1025
Local Effects of Cancer and Its Metastasis
Superior Vena Cava Syndrome	p. 1047
Spinal Cord Compression	p. 1063
Brain Metastases and Carcinomatous Meningitis	p. 1073
Bone Metastases	p. 1091
Lung Metastases	p. 1129
Liver Metastases	p. 1141
Effusions	p. 1179
Neurologic Complications	p. 1213
Pulmonary Complications of Anticancer Treatment	p. 1237
Cardiac Effects of Cancer Therapy	p. 1251
Reproductive Complications	p. 1269
Endocrine Complications	p. 1287
Second Malignant Neoplasms	p. 1297
Special Issues
Cancer in the Elderly: Biology, Prevention, and Treatment	p. 1317
Special Issues in Pregnancy	p. 1331
Specific Malignancies	p. 1345
Cancer of the Central Nervous System	p. 1347
Eye, Orbit, and Adnexal Structures	p. 1433
Cancer of the Head and Neck	p. 1497
Melanoma	p. 1561
Nonmelanoma Skin Cancers: Basal Cell and Squamous Cell Carcinomas	p. 1589
Cancer of the Endocrine System	p. 1611
Cancer of the Lung: NSCLC and SCLC	p. 1649
Tumors of the Pleura and Mediastinum	p. 1745
Cancer of the Esophagus	p. 1787
Cancer of the Stomach	p. 1819
Cancer of the Small Bowel	p. 1863
Colon Cancer	p. 1877
Cancer of the Rectum	p. 1943
Cancer of the Anal Canal	p. 1967
Liver and Bile Duct Cancer	p. 1981
Carcinoma of the Pancreas	p. 2015
Kidney and Ureter	p. 2035
Carcinoma of the Bladder	p. 2059
Prostate Cancer	p. 2085
Cancer of the Penis and Urethra	p. 2149
Testicular Cancer	p. 2175
Cancers of the Cervix, Vagina, and Vulva	p. 2217
Cancer of the Uterus	p. 2273
Ovaries and Fallopian Tubes	p. 2311
Gestational Trophoblastic Disease	p. 2347
Cancer of the Breast	p. 2369
Sarcomas of Bone	p. 2471
Sarcomas of Soft Tissue	p. 2573
Unknown Primary Cancer	p. 2627
HIV-Associated Malignancies	p. 2647
Pediatric Solid Tumors	p. 2661
The World Health Organization Classification of Hematologic Malignancies	p. 2723
Childhood Leukemia	p. 2731
Childhood Lymphoma	p. 2765
Acute Lymphoid Leukemia in Adults	p. 2793
Acute Myeloid Leukemia in Adults	p. 2825
The Myelodysplastic Syndromes	p. 2849
Chronic Myeolo-proliferative Diseases	p. 2883
Chronic Myeloid Leukemia	p. 2899
Chronic Lymphoid Leukemias	p. 2921
Hairy Cell Leukemia	p. 2941
Multiple Myeloma and Related Disorders	p. 2955
Hodgkin's Lymphoma	p. 2985
Non-Hodgkin's Lymphoma	p. 3015
Cutaneous T-Cell Lymphoma and Cutaneous B-Cell Lymphoma	p. 3077
Adult T-Cell Leukemia-Lymphoma	p. 3109
Index	p. 3131
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