Clinical Pharmacokinetics

by Rowland, Malcolm; Tozer, Thomas N.

• ISBN13: 9780812111606
• ISBN10: 0812111605
• Format: Hardcover
• Copyright: 1989-01-01
• Publisher: Lea & Febiger

Summary

Since pharmacokinetics can greatly affect how different patients respond to the same drug, both students and physicians need a basic clinical understanding of this vital area. The Third Edition of Clinical Pharmacokinetics provides a practical perspective, with these added features considerations of both stereochemistry and the increasing number of polypeptide and protein drugs being developed; the range and number of problems at the end of each chapter has been expanded; a second color added to make the text more user friendly; important equations highlighted by shading.

Table of Contents

Definitions of Symbols
Why Clinical Pharmacokinetics?	p. 1
Basic Considerations	p. 11
Intravenous Dose	p. 18
Extravascular Dose	p. 34
Therapeutic Response and Toxicity	p. 53
Constant-Rate Regimens	p. 66
Multiple-Dose Regimens	p. 83
Movement Through Membranes	p. 109
Absorption	p. 119
Distribution	p. 137
Elimination	p. 156
Integration With Kinetics	p. 184
Variability	p. 203
Genetics	p. 220
Age and Weight	p. 230
Disease	p. 248
Interacting Drugs	p. 267
Concentration Monitoring	p. 290
Distribution Kinetics	p. 313
Pharmacologic Response	p. 340
Metabolite Kinetics	p. 367
Dose and Time Dependencies	p. 394
Turnover Concepts	p. 424
Dialysis	p. 443
Selected Reading	p. 463
Appendix I. Additional Concepts and Derivations	p. 469
Appendix II. Answers to Problems	p. 507
Index	p. 586
Table of Contents provided by Blackwell. All Rights Reserved.