Clinical Research in Oral Health

by Editor: William V. Giannobile (University of Michigan); Editor: Brian A. Burt (University of Michigan); Editor: Robert J. Genco (State University of New York at Buffalo)

• ISBN13: 9780813820552
• ISBN10: 0813820553
• Format: eBook
• Copyright: 2009-12-01
• Publisher: Wiley-Blackwell

Summary

Clinical Research in Oral Health surveys the essentials of clinical research in oral health, anchoring these principles within the specific context of the oral health arena. Addressing research questions exclusively applicable to dentistry and oral health, the book thoroughly illustrates the principles and practice of oral health clinical research. Clinical Research in Oral Health also clarifies the framework of regulatory issues and presents emerging concepts in clinical translation, relating the research principles to clinical improvement.

Author Biography

William V. Giannobile is a William K. & Mary Anne Najjar Endowed Professor of Dentistry and Biomedical Engineering at the University of Michigan. He is also the Director of the Michigan Center for Oral Health Research and an Associate Editor of the Journal of Periodontology.

Robert J. Genco is a State University of New York Distinguished Professor of Oral Biology, and Microbiology, and Immunology at the University at Buffalo. He is also the Vice Provost and Director of the University at Buffalo Office of Science, Technology Transfer and Economic Outreach, and Editor-in-Chief Emeritus of the Journal of Periodontology.

Brian A. Burt is Professor Emeritus, Department of Epidemiology, and formerly the Director, Program in Dental Public Health, School of Public Health; and Professor Emeritus, School of Dentistry, University of Michigan, Ann Arbor, MI. He was editor of the journal Community Dentistry and Oral Epidemiology from 1997 to 2007.

Table of Contents

Clinical and Translational Research: Implications in the Promotion of Oral Health

Ethics in Oral Health Research

Responsibilities of Institutions and Individuals in Clinical Research in the Oral Health Sciences

Regulatory Process for the Evaluation of Dental Drugs, Devices and Biologics

Clinical and Translational Research Grantsmanship: Funding Opportunities and Obtaining Research Support

Data Management in Oral Health Research

Hypothesis Testing and Avoiding False-Positive Conclusions

Outcomes in Oral Health Research

Examiner Training: Standardization and Calibration in Periodontal Studies

Observational Studies in Oral Health Research

Initial Clinical Trials Allow Assessment of Safety, Dosing and Preliminary Efficacy Prior to Large Randomized Controlled Pivotal Studies

Phase III Pivotal Clinical Trials: Clinical Decision-making

Post-Marketing Surveillance

Dental Practice-Based Research Networks

The Technology Transfer Process for Life Science Innovations in Academic Institutions

Adoption of New Technologies for Clinical Practice

Publication of Research Findings

The Evidence-base for Oral Health

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