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Note: Supplemental materials are not guaranteed with Rental or Used book purchases.
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Contributors vii
Preface xi
Part I: The frame
1 The exclusion of older subjects from clinical trials: the PREDICT study 3Antonio Cherubini & Peter Crome
2 Clinical trials in older adults: a point of view from the industry 23Susanna Del Signore & Philippe Guillet
3 Ethical issues in clinical trials involving older subjects: the right to participate in clinical trials and have access to care; the protection of vulnerable subjects and the issue of informed consent 45Emmanuel Hirsch & Paul]Loup Weil]Dubuc
Part II: The implementation
4 Mastering the design of clinical trials for older persons: the tension between external validity and feasibility 63Luigi Ferrucci & Stephanie Studenski
5 Pharmacokinetic and pharmacodynamic studies in older adults 79Arduino A. Mangoni, Paul A.F. Jansen & Stephen H.D. Jackson
6 The role of comprehensive geriatric assessment (CGA) of older adults in clinical studies 95Graziano Onder, Agnese Collamati, Andrea Poscia & Roberto Bernabei
7 Statistical issues in designing and interpreting clinical trials in older adults 107Heather Allore, Mark A. Espeland & Michael E. Miller
Part III: The examples
8 Challenges in implementing large]scale clinical trials in moderately functioning older adults 127Stephen D. Anton, Sandrine Sourdet, Marco Pahor & Todd Manini
9 Clinical trials in Alzheimer’s disease 153Julien Delrieu & Bruno Vellas
10 Clinical trials in late]life mood disorders 173Lucio Ghio, Werner Natta, Marco Vaggi & Luigi Ferrannini
11 Clinical trials for conditions of low muscle mass and strength 197Stephanie Studenski, Rosaly Correa-de-Araujo & Luigi Ferrucci
12 Clinical trials of cancer treatment in the elderly 219Lodovico Balducci. Iordanis Gravanis & Francesco Pignatti
13 Clinical trials in nursing homes: challenges and practical solutions 231Sandra Simmons, Barbara Resnick, John Schnelle & Joseph G. Ouslander
Index 255
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