Clinicians' Guide to Viral Hepatitis

by Smith, Heather M.

• ISBN13: 9780340763049
• ISBN10: 0340763043
• Format: Paperback
• Copyright: 2001-06-21
• Publisher: Hodder Education Publishers

Summary

This book is written for general medicine physicians and primary care doctors who wish to understand the hepatitis virus sufficiently to be able to counsel, advise and treat their patients. It gives clear explanations of the main aspects of these infections with particular reference to the management of infected individuals. The book is clearly designed to make the information as accessible as possible.

Table of Contents

Preface	ix
Abbreviations and glossary	xi
References and the Web	xv
History and isolation of hepatitis viruses	1	(8)
Early descriptions	1	(1)
Evolutionary history	2	(2)
Isolation and nomenclature	4	(3)
Additional reading	7	(2)
The clinical features of viral hepatitis infection	9	(12)
Definitions	9	(1)
Symptoms of acute hepatitis	10	(1)
Investigations	11	(1)
Symptoms of chronic hepatitis	11	(1)
Symptoms associated with cirrhosis	12	(2)
Extra-hepatic manifestations of chronic hepatitis	14	(2)
Acute (fulminant) liver failure	16	(3)
Additional reading	19	(2)
Investigations and their interpretation	21	(22)
Liver function tests	21	(3)
Radiology	24	(1)
Hepatitis serology	25	(13)
Liver biopsy	38	(4)
Additional reading	42	(1)
The natural history and prognosis of viral hepatitis	43	(18)
Hepatitis A	43	(2)
Hepatitis B	45	(3)
Hepatitis D	48	(1)
Hepatitis C	49	(7)
Hepatitis E	56	(1)
Hepatitis G	56	(1)
Hepatocellular carcinoma	57	(1)
Conclusions	58	(1)
Additional reading	58	(3)
Epidemiology	61	(18)
Hepatitis A	61	(3)
Hepatitis E	64	(1)
Hepatitis B	65	(4)
Hepatitis D	69	(1)
Hepatitis C	70	(6)
Hepatitis G	76	(1)
TTV	77	(1)
Additional reading	78	(1)
Management principles	79	(12)
Counselling the patient	79	(5)
Screening family members	84	(1)
Attitudes to hepatitis carriers	85	(1)
Symptoms	85	(1)
Treatment	86	(1)
Drug use and hepatitis	87	(2)
Additional reading	89	(2)
Treatment of viral hepatitis	91	(24)
Why treat?	91	(1)
Fulminant hepatitis	91	(1)
Acute hepatitis	92	(1)
Chronic hepatitis	93	(6)
Chronic HBV infection	99	(7)
Chronic HDV infection	106	(1)
Chronic HCV infection	107	(6)
Future directions	113	(1)
Additional reading	113	(2)
Liver transplantation in viral hepatitis	115	(12)
Introduction	115	(1)
Liver transplantation for acute (fulminant) liver failure	115	(3)
Liver transplantation for chronic viral hepatitis	118	(1)
Transplantation for chronic hepatitis B and D	119	(2)
Transplantation for chronic hepatitis C	121	(2)
Transplantation for multiple viral infections	123	(1)
Human immunodeficiency virus infection and transplantation	124	(1)
Re-transplantation	124	(1)
Conclusions	124	(1)
Additional reading	125	(2)
Prevention of viral hepatitis	127	(8)
Hepatitis A	127	(3)
Hepatitis B	130	(3)
Hepatitis C	133	(1)
Hepatitis E	133	(1)
Additional reading	134	(1)
Interactions	135	(8)
Hepatitis viral interactions	135	(7)
Additional reading	142	(1)
Pathogenesis of viral hepatitis	143	(10)
Why is clinical outcome so varied?	143	(3)
What causes cells to die?	146	(2)
Why do viruses persist?	148	(3)
What causes fibrosis to occur?	151	(1)
Additional reading	152	(1)
Molecular biology	153	(24)
Hepatitis A	153	(2)
Hepatitis B	155	(5)
Hepatitis D	160	(2)
Hepatitis C	162	(4)
Hepatitis E	166	(1)
Hepatitis G	167	(1)
TTV	167	(1)
Molecular variants	168	(6)
Conclusion	174	(1)
Additional reading	174	(3)
References	177	(8)
Index	185