Color Atlas and Text of Pulmonary Pathology

by Cagle, Philip T.; Allen, Timothy C.; Barrios, Roberto; Bedrossian, Carlos; Haque, Abida K.; Laga, Alvaro C.; Ostrowski, Mary L.; Zander, Dani S.

• ISBN13: 9780781734530
• ISBN10: 0781734533
• Format: Hardcover
• Copyright: 2004-09-21
• Publisher: LWW

Summary

Prepared by renowned experts in pulmonary pathology, this comprehensive and profusely illustrated text-atlas presents a multimodality approach to the diagnosis of lung disease--preparing you to face your next challenge with confidence. For the practicing pathologist, the book provides a roadmap to faster, more accurate diagnosis of lung disease...and for the fellow, resident, or student, it is an indispensable study tool, ideal when preparing for exams or subspecialty Board certification. Precise diagnosis of lung pathology begins here. . Unmatched coverage addresses the full spectrum of lung pathology--from lung cancer and emphysema to infectious diseases and transplant-related problems--with in-depth material on common, rare, and newly described disease entities. . Detailed discussions of the gross, cytologic, and histologic features of each disease broaden your understanding and sharpen your diagnostic skills. . Expert authors let you benefit from their years of diagnostic experience. . Over 1,100 full-color illustrations reveal critical details from among a broad range of findings, obtained using the latest diagnostic modalities. . Use of the most current classification schemes in lung disease assures you of the most current, accurate guidelines. . Special topics address the challenges of drug-related lung problems, forensic pathology, pediatric pulmonary pathology, and more.

Table of Contents

Contributing Authors	xix
Preface	xxiii
Acknowledgements	xxv
Section 1 Normal Cytology and Histology	1	(18)
Bronchus	3	(2)
Bronchioles and Alveolar Ducts	5	(4)
Blood Vessels and Lymphatics	9	(4)
Alveoli	13	(2)
Pleura	15	(2)
Normal Cytology of the Lung and Pleura	17	(2)
Section 2 Artifacts and Age-Related Changes	19	(14)
Procedural and Laboratory Artifacts	21	(4)
Reactive Changes, Nonspecific Findings, and Age-Related Changes	25	(4)
Noncellular Structures	29	(4)
Section 3 Malignant Neoplasms	33	(136)
Carcinomas	35	(46)
Adenocarcinoma	35	(8)
Adenocarcinoma with Micropapillary Component	40	(1)
Fetal Adenocarcinoma	40	(3)
Bronchioloalveolar Carcinomas	43	(3)
Squamous Cell Carcinoma	46	(4)
Papillary Squamous Cell Carcinoma	49	(1)
Large Cell Carcinoma	50	(2)
Small Cell Carcinoma	52	(6)
Combined Small Cell and Non--Small Cell Carcinoma	56	(2)
Carcinoid Tumor	58	(3)
Atypical Carcinoid	61	(2)
Large Cell Neuroendocrine Carcinoma	63	(2)
Adenosquamous Carcinoma	65	(2)
Basaloid Carcinoma	67	(1)
Sarcomatoid (Sarcomatous) Carcinoma	68	(3)
Giant Cell Carcinoma	71	(1)
Pulmonary Blastoma	72	(2)
Mucoepidermoid Carcinoma	74	(2)
Adenoid Cystic Carcinoma	76	(2)
Metastatic Carcinoma	78	(3)
Sarcomas	81	(24)
Sarcoma of the Pulmonary Artery and Vein	81	(2)
Angiosarcoma	83	(1)
Epithelioid Hemangioendothelioma	84	(2)
Kaposi Sarcoma	86	(1)
Hemangiopericytoma	86	(1)
Undifferentiated Sarcomas	87	(1)
Fibrosarcoma	88	(2)
Malignant Peripheral Nerve Sheath Tumor	90	(1)
Osteosarcoma	91	(2)
Chondrosarcoma	93	(1)
Synovial Sarcoma	94	(2)
Leiomyosarcoma	96	(1)
Rhabdomyosarcoma	97	(2)
Liposarcoma	99	(2)
Alveolar Soft Part Sarcoma	101	(1)
Glomangiosarcoma (Malignant Glomus Tumor)	102	(3)
Hematologic Malignancies	105	(20)
Extranodal Marginal Zone B-Cell Lymphoma	106	(2)
Primary Large B-Cell Lymphoma	108	(2)
Lymphomatoid Granulomatosis	110	(2)
Primary Hodgkin Lymphoma	112	(2)
Systemic Lymphomas and Leukemias Involving the Lung and Pleura	114	(11)
Acute Myeloid Leukemia	114	(1)
B-Cell Lymphoproliferative Disorders	115	(4)
Hodgkin Disease	119	(1)
Systemic T-Cell Lymphoma	120	(3)
Multiple Myeloma and Related Conditions	123	(2)
Other Cancers of the Lung	125	(4)
Malignant Melanoma	125	(2)
Pleuropulmonary Thymoma	127	(2)
Metaplastic, Dysplastic, and Premalignant Lesions	129	(14)
Squamous Metaplasia and Dysplasia and Carcinoma In Situ	129	(4)
Squamous Metaplasia	129	(2)
Squamous Dysplasia	131	(1)
Carcinoma In Situ	132	(1)
Squamous Papilloma and Papillomatosis	133	(5)
Glandular Papilloma and Mixed Squamous and Glandular Papilloma	136	(2)
Atypical Adenomatous Hyperplasia	138	(2)
Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia	140	(1)
Bronchiolar Columnar Cell Dysplasia	141	(2)
Cancers of the Pleura	143	(22)
Diffuse Malignant Mesothelioma	143	(6)
Localized Malignant Mesothelioma	149	(1)
Well-Differentiated Papillary Mesothelioma	150	(2)
Synovial Sarcoma	152	(2)
Vascular Sarcoma	154	(2)
Malignant Solitary Fibrous Tumor	156	(2)
Pseudomesotheliomatous Carcinoma	158	(2)
Primitive Neuroectodermal Tumor (Askin tumor)	160	(1)
Desmoplastic Small Round Cell Tumor	161	(1)
Primary Effusion Lymphoma	162	(1)
Pleural Metastases	163	(2)
Immunohistochemistry of Pulmonary and Pleural Neoplasia	165	(4)
Section 4 Benign Neoplasms	169	(46)
Hamartoma	171	(2)
Solitary Fibrous Tumor	173	(4)
Desmoid Tumor	175	(2)
Carcinoid Tumorlets	177	(2)
Minute Meningothelial-Like Nodule (Chemodectoma)	179	(2)
Sclerosing Hemangioma	181	(4)
Rare Adenomas	185	(4)
Alveolar Adenoma	185	(1)
Papillary Adenoma	186	(2)
Mucinous Cystadenoma	188	(1)
Seromucinous Gland Neoplasms	189	(6)
Mucous Gland Adenoma	189	(1)
Salivary-Glandlike Tumors	190	(5)
Oncocytoma	191	(1)
Pleomorphic Adenoma	192	(3)
Rare Mesenchymal Tumors	195	(8)
Leiomyoma	195	(1)
Lipoma	196	(1)
Chondroma	197	(1)
Neural and Related Tumors	198	(5)
Granular Cell Tumor	198	(1)
Schwannoma	199	(1)
Neurofibroma	200	(1)
Ganglioneuroma	201	(1)
Meningioma	202	(1)
Lymphangioleiomyomatosis	203	(6)
Multifocal Micronodular Pneumocyte Hyperplasia	205	(1)
Clear Cell Tumor (``Sugar Tumor'')	206	(3)
Pulmonary and Pleural Lymphangiomatosis	209	(2)
Glomus Tumor	211	(2)
Giant Cell Tumor	213	(2)
Section 5 Histiocytoses	215	(8)
Pulmonary Langerhans Cell Histiocytosis	217	(2)
Non-Langerhans Cell Histiocytoses	219	(4)
Erdheim-Chester Disease	219	(1)
Rosai-Dorfman Disease	219	(4)
Section 6 Benign and Borderline Lymphoid Proliferations	223	(6)
Lymphoid Interstitial Pneumonia	225	(2)
Nodular Lymphoid Hyperplasia	227	(2)
Section 7 Focal Lesions and Pseudotumors	229	(20)
Apical Scars	231	(2)
Focal Scars	233	(2)
Dendriform Ossification	235	(2)
Intrapulmonary Lymph Node	237	(2)
Inflammatory Pseudotumor/Inflammatory Myofibroblastic Tumor	239	(4)
Rounded Atelectasis	243	(2)
Nodular Amyloidosis	245	(4)
Tracheobronchial Amyloidosis	247	(2)
Section 8 Granulomatous Diseases	249	(26)
Infectious Granulomas	251	(4)
Tuberculosis	251	(1)
Fungi	252	(1)
Parasites	253	(2)
Bronchocentric Granulomatosis	255	(2)
Pulmonary Hyalinizing Granuloma	257	(2)
Sarcoidosis	259	(2)
Necrotizing Sarcoid Granulomatosis	261	(2)
Sarcoidlike Reaction	263	(2)
Berylliosis	265	(2)
Foreign Body Granulomas	267	(4)
Intravenous Drug Abuse	267	(2)
Aspiration	269	(1)
Other Foreign Body Reactions	270	(1)
Nodules Resembling Granulomas	271	(4)
Rheumatoid Nodules	271	(1)
Malakoplakia	272	(3)
Section 9 Diffuse Pulmonary Hemorrhage	275	(20)
Pulmonary Hemorrhage Without Vasculitis	277	(8)
Hemorrhage Without Other Histologic Abnormalities	277	(1)
Hemorrhage Associated with Infections	278	(2)
Hemorrhage with Diffuse Alveolar Damage	280	(1)
Chronic Passive Congestion and Congestive Vasculopathy	281	(1)
Arteriovenous Malformation	282	(1)
Idiopathic Pulmonary Hemosiderosis	283	(2)
Pulmonary Hemorrhage with Vasculitis	285	(10)
Vasculitis in Collagen Vascular Diseases	285	(1)
Antiglomerular Basement Membrane Antibody Disease (Goodpasture Syndrome)	286	(1)
Wegener's Granulomatosis	287	(3)
Churg-Strauss Syndrome	290	(2)
Microscopic Polyarteritis	292	(1)
Bechet Disease	293	(2)
Section 10 Pulmonary Hypertension and Emboli	295	(20)
Primary Pulmonary Hypertension	297	(2)
Secondary Pulmonary Hypertension	299	(2)
Pulmonary Veno-Occlusive Disease	301	(2)
Pulmonary Capillary Hemangiomatosis	303	(2)
Pulmonary Thrombi and Emboli	305	(8)
Thromboemboli	305	(1)
Disseminated Intravascular Coagulation	306	(1)
Foreign Body Emboli	307	(1)
Bone Marrow Emboli	308	(1)
Amniotic Fluid Emboli	309	(1)
Body Tissues Emboli	309	(1)
Tumor Emboli	310	(1)
Parasitic Emboli	311	(1)
Air Emboli	311	(2)
Pulmonary Infarct	313	(2)
Section 11 Large Airways	315	(12)
Bronchiectasis	317	(4)
Middle Lobe Syndrome	318	(3)
Chronic Bronchitis	321	(2)
Asthma	323	(4)
Mucoid Impaction	324	(1)
Allergic Bronchopulmonary Aspergillosis	325	(2)
Section 12 Small Airways	327	(22)
Bronchiolar and Peribronchiolar Inflammation, Fibrosis, and Metaplasia	329	(4)
Bronchopneumonia	333	(2)
Organizing Pneumonia (Bronchiolitis Obliterans Organizing Pneumonia)	335	(4)
Constrictive Bronchiolitis	339	(2)
Respiratory Bronchiolitis and Membranous Bronchiolitis	341	(2)
Follicular Bronchiolitis	343	(2)
Diffuse Panbronchiolitis	345	(2)
Small Airways and Inorganic Dusts	347	(2)
Section 13 Alveolar Infiltrates	349	(24)
Acute Pneumonia	351	(6)
Necrotizing Pneumonia	352	(1)
Pulmonary Abscess	353	(2)
Aspiration Pneumonia	355	(2)
Organizing Acute Pneumonia	357	(2)
Pulmonary Edema	359	(2)
Diffuse Alveolar Damage	361	(2)
Acute Fibrinous and Organizing Pneumonia	363	(2)
Lipoid Pneumonia	365	(2)
Eosinophilic Pneumonia	367	(2)
Desquamative Interstitial Pneumonialike Pattern	369	(2)
Pulmonary Alveolar Proteinosis	371	(2)
Section 14 Tobacco-Related Diseases	373	(10)
Emphysema	375	(2)
Membranous Bronchiolitis	377	(2)
Respiratory Bronchiolitis	379	(2)
Respiratory Bronchiolitis-Associated Interstitial Lung Disease/Desquamative Interstitial Pneumonia	381	(2)
Section 15 Diffuse Interstitial Lung Diseases	383	(40)
Infectious Interstitial Pneumonias	385	(2)
Hypersensitivity Pneumonitis	387	(2)
Hot Tub Lung	389	(2)
Flock Lung	391	(2)
Pneumoconioses	393	(20)
Asbestosis	393	(4)
Silicosis	397	(3)
Silicatosis	400	(3)
Mixed Pneumoconiosis and Mixed Dust Pneumoconiosis	403	(2)
Coal Worker's Pneumoconiosis	405	(2)
Giant Cell Interstitial Pneumonia/Hard Metal Pneumoconiosis	407	(1)
Siderosis	408	(2)
Aluminosis	410	(3)
Interstitial Disease in Collagen Vascular Diseases	413	(2)
Organized Diffuse Alveolar Damage	415	(2)
Diffuse Alveolar-Septal Amyloidosis	417	(2)
Honeycomb Lung	419	(2)
Lung Disease in Inflammatory Bowel Disease	421	(2)
Section 15 Idiopathic Interstitial Pneumonias	423	(12)
Acute Interstitial Pneumonia	425	(2)
Usual Interstitial Pneumonia	427	(4)
Nonspecific Interstitial Pneumonia	431	(2)
Cryptogenic Organizing Pneumonia (Idiopathic Bronchiolitis Obliterans Organizing Pneumonia)	433	(2)
Section 17 Specific Infectious Agents	435	(72)
Viruses	437	(16)
Cytomegalovirus	437	(2)
Herpes Simplex Virus	439	(1)
Influenza and Parainfluenza Virus Pneumonia	440	(2)
Adenovirus	442	(1)
Respiratory Syncytial Virus	443	(1)
Measles Virus	444	(1)
Varicella-Zoster Virus	445	(1)
Hantavirus	446	(1)
Severe Acute Respiratory Syndrome	447	(2)
Viral Hemorrhagic Fevers	449	(4)
Arenavirus Hemorrhagic Fevers	449	(1)
Yellow Fever	450	(3)
Mycoplasma	453	(2)
Bacteria	455	(12)
Pseudomonas	455	(1)
Klebsiella Pneumonia	456	(2)
Staphylococcus	458	(1)
Nocardia	459	(2)
Actinomyces	461	(1)
Legionella	462	(2)
Leptospirosis	464	(1)
Rhodococcus	465	(2)
Rickettsia and Related Organisms	467	(4)
Rickettsia	467	(1)
Ehrlichia	468	(3)
Fungus	471	(16)
Aspergillus	471	(2)
Mucormycosis	473	(1)
Pneumocystis	474	(2)
Cryptococcus	476	(2)
Histoplasma	478	(1)
Coccidioides	479	(2)
Paracoccidioidomycosis	481	(1)
Blastomycosis	481	(2)
Candida	483	(1)
Sporotrichosis	484	(1)
Phaeohyphomycosis	485	(2)
Mycobacteria	487	(4)
Tuberculosis	487	(2)
Atypical Mycobacteria	489	(2)
Parasites	491	(12)
Dirofilaria	491	(1)
Strongyloides	492	(1)
Malaria	493	(1)
Toxoplasma	494	(1)
Entamoeba Histolytica	495	(1)
Acanthamoeba	496	(1)
Paragonimus	497	(2)
Ascaris	499	(1)
Schistosoma	500	(1)
Leishmania	501	(1)
Echinococcus	501	(2)
Agents of Biologic and Chemical Warfare	503	(4)
Anthrax	503	(1)
Tularemia	504	(1)
Chemicals	505	(2)
Section 18 Transplant-Related Pathology	507	(28)
Acute Lung Transplant Rejection	509	(4)
Chronic Lung Transplant Rejection	513	(2)
Hyperacute Rejection of the Transplanted Lung	515	(2)
Lung Transplant Anastomotic Complications	517	(2)
Transplant-Related Infections	519	(4)
Ischemia-Reperfusion Injury in the Transplanted Lung	523	(2)
Organizing Pneumonia in the Transplanted Lung	525	(2)
Other Lung Transplant-Related Pathology	527	(2)
Post-Transplant Lymphoproliferative Disorders	529	(4)
Graft Versus Host Disease	533	(2)
Sectio 19 Lung Pathology in Collagen Vascular Diseases	535	(6)
Lung Pathology in Collagen Vascular Diseases	537	(4)
Section 20 Therapeutic Drug Reactions and Radiation Effects	541	(16)
Amiodarone	543	(2)
Methotrexate	545	(2)
Phen-fen	547	(2)
Mesalamine	549	(2)
Other Drugs	551	(4)
Radiation Pneumonitis	555	(2)
Section 21 Forensic Pathology	557	(12)
Drowning	559	(2)
Fires and Smoke Inhalation	561	(2)
Contusions	563	(2)
Intravenous Drug Abuse	565	(2)
Cocaine Abuse	567	(2)
Section 22 Metabolic Disorders/Storage Diseases	569	(8)
Pulmonary Alveolar Microlithiasis	571	(2)
Pulmonary Calcification	573	(2)
Storage Diseases	575	(2)
Section 23 Non-Neoplastic Lesions of the Pleura	577	(16)
Fibrinous and Fibrous Pleuritis	579	(4)
Specific Forms of Pleuritis	583	(4)
Reactive Mesothelial Hyperplasia	587	(2)
Endometriosis	589	(2)
Splenosis	591	(2)
Section 24 Pediatric Pulmonary Pathology	593	(44)
Childhood Asthma	595	(2)
Bronchial Atresia and Intralobar Sequestration	597	(4)
Extralobar Sequestration	601	(2)
Bronchogenic Cyst	603	(2)
Congenital Cystic Adenomatoid Malformation, Large Cyst Type	605	(2)
Pulmonary Hyperplasia and Related Disorders	607	(2)
Congenital Lobar Overinflation	609	(2)
Complications of Prematurity	611	(4)
Lymphatic Disorders	615	(2)
Tissue Heterotopia and Related Abnormalities	617	(2)
Neuroendocrine Hyperplasia of Childhood (Persistent Tachypnea of Infancy)	619	(2)
Surfactant Protein B Deficiency and Pulmonary Alveolar Proteinosis	621	(2)
Surfactant Protein C Deficiency and Chronic Pneumonitis of Infancy	623	(2)
Cystic Fibrosis	625	(2)
Alveolar Capillary Dysplasia with Misalignment of Pulmonary Veins	627	(2)
Acinar Dysgenesis/Aplasia	629	(2)
Pleuropulmonary Blastoma	631	(4)
Pulmonary Leiomyoma and Leiomyosarcoma in Childhood	635	(2)
Bibliography	637	(20)
Index	657