Combinatorial Chemistry in Biology

by Famulok, M.; Winnacker, E. L.; Wong, Cindy H.

• ISBN13: 9783540657040
• ISBN10: 3540657045
• Edition: 1st
• Format: Hardcover
• Copyright: 1999-08-01
• Publisher: Springer Verlag

Summary

Kekule-Institut, Bonn, Germany. Offers an overview of various strategies of encoded combinatorial chemistry of peptides or proteins. Also discusses evolutionary aspects of protein engineering, screening of nucleic acid libraries, and perspectives and prospects of synthetic biology. For researchers.

Table of Contents

Peptide Libraries in Cellular Immune Recognition	1	(22)
S. Uebel
K.H. Wiesmuller
G. Jung
R. Tampe
Antigen Sequence- and Library-Based Mapping of Linear and Discontinuous Protein-Protein-Interaction Sites by Spot Synthesis	23	(14)
U. Reineke
A. Kramer
J. Schneider-Mergener
The Two Hybrid Toolbox	37	(18)
W. Kolanus
Evolutionary Approaches to Protein Engineering	55	(32)
B. Steipe
Phage Display of Combinatorial Peptide and Protein Libraries and Their Applications in Biology and Chemistry	87	(20)
K. Johnsson
L. Ge
In Vitro Selection Methods for Screening of Peptide and Protein Libraries	107	(16)
J. Hanes
A. Pluckthun
Aptamers as Tools in Molecular Biology and Immunology	123	(14)
M. Famulok
G. Mayer
In Vitro Selection of Nucleic Acid Enzymes	137	(22)
M. Kurz
R.R. Breaker
Dynamic Combinatorial Chemistry: Evolutionary Formation and Screening of Molecular Libraries	159	(14)
A.V. Eliseev
J.M. Lehn
Evolutionary Biotechnology - Reflections and Perspectives	173	(14)
U. Kettling
A. Koltermann
M. Eigen
Subject Index	187